Browse by Phase
Phase 2 Clinical Trials
Phase 2 trials study whether a drug works in people with a specific disease or condition. These studies enroll 100–300 participants and also continue to evaluate safety.
Total Trials
1,078
Recruiting Now
1,078
Top Conditions in Phase 2
Frequently Asked Questions — Phase 2 Trials
What does a Phase 2 clinical trial evaluate?
Phase 2 trials assess whether a drug or treatment works in people with a specific disease or condition. Enrolling 100–300 participants, these studies collect preliminary efficacy data while continuing to monitor safety and identify the optimal dosing regimen. A successful Phase 2 outcome is required to advance to large-scale Phase 3 testing.
How long do Phase 2 trials typically take?
Phase 2 clinical trials typically run for 1–4 years, depending on the condition, endpoint complexity, and enrollment rate. Rare disease trials or those with long-term outcome measures may run longer. Many sponsors run Phase 2 studies at multiple sites simultaneously to accelerate recruitment.
Who can participate in a Phase 2 clinical trial?
Eligibility for Phase 2 trials is defined by specific inclusion and exclusion criteria. Participants are typically patients diagnosed with the condition under study and may or may not have received prior treatment. Age, disease stage, comorbidities, and laboratory values are common eligibility factors. Review each trial's criteria on ClinicalTrials.gov for specific requirements.
Active Phase 2 Studies
NCT06201078 Phase 2
Recruiting
Stereotactic Re-irradiation of Local Recurrences of Prostate Cancer After Radiot...
Condition
Local Recurrence of Malignant Tumor of Prostate
Enrollment
55 pts
Location
Poland
Sponsor
Maria Sklodowska-Curie Nationa
NCT06581640 Phase 2
Recruiting
Chimeric Antigen Receptor Modified T Cells Targeting BCMA for the Treatment of R...
Condition
Multiple Myeloma
Enrollment
5 pts
Location
China
Sponsor
The First Affiliated Hospital
NCT07534033 Phase 2
Recruiting
Phase II Clinical Study of Probiotic LR607 in Patients With Non-Small Cell Lung ...
Condition
NSCLC Diagnosed by Histology or Cytology
Enrollment
46 pts
Location
China
Sponsor
Zhujiang Hospital
NCT06200155 Phase 2
Recruiting
Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenanc...
Condition
Depression, Anxiety
Enrollment
48 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
NCT05493215 Phase 2
Recruiting
Imatinib TDM in GIST
Condition
Gastrointestinal Stromal Tumors
Enrollment
28 pts
Location
United States
Sponsor
Reema A. Patel
NCT06812715 Phase 2
Recruiting
Clonal Dynamics of Chronic Lymphocytic Leukaemia Treated With Pirtobrutinib Afte...
Condition
Chronic Lymphocytic Leukemia
Enrollment
40 pts
Location
Australia
Sponsor
Peter MacCallum Cancer Centre,
NCT07191717 Phase 2
Recruiting
Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Bre...
Condition
Anatomic Stage I Breast Cancer AJCC v8
Enrollment
42 pts
Location
United States
Sponsor
Jonsson Comprehensive Cancer C
NCT05526989 Phase 2
Recruiting
Study of the Combination Dostarlimab With Niraparib In Patients With Penile Carc...
Condition
Penile Carcinoma
Enrollment
25 pts
Location
United States
Sponsor
H. Lee Moffitt Cancer Center a
NCT06829355 Phase 2
Recruiting
"Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colore...
Condition
MCRC
Enrollment
52 pts
Location
China
Sponsor
Beijing Friendship Hospital
NCT06111885 Phase 2
Recruiting
Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone P...
Condition
Kidney Stone
Enrollment
99 pts
Location
Switzerland
Sponsor
Insel Gruppe AG, University Ho
NCT06500208 Phase 2
Recruiting
Neoadjuvant Adebrelimab and Chemotherapy in High-rish ER+/HER2- BC
Condition
Breast Cancer
Enrollment
48 pts
Location
China
Sponsor
Shanghai Jiao Tong University
NCT06548789 Phase 2
Recruiting
Neoadjuvant Immune Checkpoint Blockade + a Prebiotic Food-enriched Dietary Inter...
Condition
Melanoma
Enrollment
35 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
NCT07305974 Phase 2
Recruiting
A Phase IIa Clinical Study of RG002C0106 Injection in Subjects With Primary IgA ...
Condition
IgA Nephropathy (IgAN)
Enrollment
30 pts
Location
China
Sponsor
Rigerna Therapeutics Co., Ltd.
NCT01962415 Phase 2
Recruiting
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT ...
Condition
Primary Immunodeficiency (PID)
Enrollment
100 pts
Location
United States
Sponsor
Paul Szabolcs
NCT03866668 Phase 2
Recruiting
A Study of Esomeprazole in Children With Autism
Condition
Autism
Enrollment
25 pts
Location
United States
Sponsor
Stanford University
NCT00695214 Phase 2
Recruiting
Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Ap...
Condition
Sleep Apnea, Obstructive
Enrollment
800 pts
Location
United States
Sponsor
University of California, Los
NCT04576078 Phase 2
Recruiting
Post-operative Analgesic Effect of Oral Nefopam
Condition
Postoperative Pain After a Total Knee Arthroplasty
Enrollment
50 pts
Location
France
Sponsor
Hospices Civils de Lyon
NCT06904235 Phase 2
Recruiting
Study With IV NEPA (Fosnetupitant/Palonosetron) for the Prevention of Chemothera...
Condition
Nausea and Vomiting Chemotherapy-Induced
Enrollment
95 pts
Location
Greece, Poland, Romania
Sponsor
Helsinn Healthcare SA
NCT04991025 Phase 2
Recruiting
Adding Certolizumab to Chemotherapy + Nivolumab in People Who Have Lung Cancer T...
Condition
Lung Cancer
Enrollment
60 pts
Location
United States
Sponsor
Memorial Sloan Kettering Cance
NCT06579274 Phase 2
Recruiting
Evaluation of the Safety and Efficacy of Parecoxib in Patients With Subarachnoid...
Condition
Neurological Complication
Enrollment
112 pts
Location
Czechia
Sponsor
St. Anne's University Hospital
NCT07362979 Phase 2
Recruiting
Toripalimab Combined With Different Platinum-Based Induction Chemotherapy Regime...
Condition
Nasopharyngeal Cancinoma (NPC)
Enrollment
243 pts
Location
China
Sponsor
Sun Yat-sen University
NCT04079179 Phase 2
Recruiting
Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histioc...
Condition
Langerhan's Cell Histiocytosis
Enrollment
90 pts
Location
United States
Sponsor
Carl Allen
NCT06979362 Phase 2
Recruiting
A Research Study Comparing Different Doses of CDR132L With Placebo on the Struct...
Condition
Heart Failure
Enrollment
200 pts
Location
United States, Canada, Germany
Sponsor
Novo Nordisk A/S
NCT06582446 Phase 2
Recruiting
Artificial Intelligence to Personalize Prostate Cancer Treatment (the HypoElect ...
Condition
Prostate Cancer
Enrollment
30 pts
Location
Cyprus
Sponsor
German Oncology Center, Cyprus
NCT04395196 Phase 2
Recruiting
RCT of Prenatal Choline Supplementation During Pregnancy to Mitigate Adverse Eff...
Condition
Fetal Alcohol Spectrum Disorders
Enrollment
288 pts
Location
South Africa
Sponsor
Wayne State University
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology