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head and neck squamous cell carcinoma

Total Trials
16
Recruiting Now
16
Trial Phases
Phase 2, Phase 1

ClinicalMetric tracks all active clinical trials for head and neck squamous cell carcinoma sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — head and neck squamous cell carcinoma Clinical Trials

How many clinical trials are currently recruiting for head and neck squamous cell carcinoma?
ClinicalMetric currently tracks 16 actively recruiting clinical trials for head and neck squamous cell carcinoma, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 16. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for head and neck squamous cell carcinoma?
head and neck squamous cell carcinoma research spans Phase 1 (8 trials), Phase 2 (5 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a head and neck squamous cell carcinoma clinical trial?
Eligibility criteria for head and neck squamous cell carcinoma trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
8
Phase 2
5
Top Sponsors
Fifth Affiliated Hospital, Sun Yat-Sen University 1 trial
Guangdong Provincial People's Hospital 1 trial
Nurix Therapeutics, Inc. 1 trial
IDEAYA Biosciences 1 trial
KaliVir Immunotherapeutics 1 trial

Recruiting Clinical Trials

NCT05854823
Recruiting
The Efficacy and Safety of De-escalated Postoperative Radiotherapy in Locally Advanced HNSCC With pCR/MPR
Enrollment
23 pts
Location
China
Sponsor
Fifth Affiliated Hospital, Sun...
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NCT05272696 Phase 2
Recruiting
Pembrolizumab and Induction Chemotherapy in Locally Advanced HNSCC
Enrollment
86 pts
Location
China
Sponsor
Guangdong Provincial People's ...
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NCT05107674 Phase 1
Recruiting
A Study of NX-1607 in Adults With Advanced Malignancies
Enrollment
345 pts
Location
United States, Unite...
Sponsor
Nurix Therapeutics, Inc.
View Trial →
NCT07503808 Phase 1
Recruiting
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
Enrollment
150 pts
Location
United States
Sponsor
IDEAYA Biosciences
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NCT06444815 Phase 1
Recruiting
A Study of VET3-TGI in Patients With Solid Tumors
Enrollment
60 pts
Location
United States
Sponsor
KaliVir Immunotherapeutics
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NCT04722523 Phase 1
Recruiting
A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer
Enrollment
40 pts
Location
United States
Sponsor
Memorial Sloan Kettering Cance...
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NCT06006169 Phase 2
Recruiting
A Study of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid Tumors
Enrollment
186 pts
Location
China
Sponsor
Sichuan Baili Pharmaceutical C...
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NCT04291105 Phase 2
Recruiting
Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients
Enrollment
87 pts
Location
United States, Brazi...
Sponsor
Vyriad, Inc.
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NCT05945875 Phase 1
Recruiting
Evaluating the Use of Dual Imaging Techniques for Detection of Disease in Patients With Head and Neck Cancer
Enrollment
40 pts
Location
United States
Sponsor
Vanderbilt-Ingram Cancer Cente...
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NCT06662929
Recruiting
Arabic PRO Measures for Head and Neck Cancer Radiotherapy.
Enrollment
125 pts
Location
Saudi Arabia
Sponsor
King Saud University
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NCT04857164 Phase 2
Recruiting
Study of Pembrolizumab Combined with Chemotherapy in the First Line Therapy for R/M HNSCC in China
Enrollment
150 pts
Location
China
Sponsor
Yuankai Shi
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NCT06999187 Phase 1
Recruiting
A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas
Enrollment
96 pts
Location
United States
Sponsor
Dren Bio
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NCT06150664 Phase 1
Recruiting
A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
Enrollment
85 pts
Location
United States
Sponsor
Compass Therapeutics
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NCT06995508 Phase 2
Recruiting
Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial
Enrollment
66 pts
Location
United States
Sponsor
Roswell Park Cancer Institute
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NCT05952947 Phase 1
Recruiting
HRYZ-T101 Injection for HPV18 Positive Solid Tumor
Enrollment
32 pts
Location
China
Sponsor
HRYZ Biotech Co.
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NCT04564989
Recruiting
Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC
Enrollment
220 pts
Location
United States
Sponsor
UNC Lineberger Comprehensive C...
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology