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non small cell lung cancer

Total Trials
75
Recruiting Now
75
Trial Phases
Phase 2, Phase 3, Phase 1
NCT06476093
Recruiting

SRT Combined With Anlotinib for the Treatment of Brain Metastases From Non-small Cell Lung Cancer

Enrollment
46 pts
Location
China
Sponsor
The First People's Hospital of...
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NCT06272864
Recruiting

BostonGene and Exigent Genomic INsight Study

Enrollment
400 pts
Location
United States
Sponsor
BostonGene
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NCT06809764
Recruiting

Clinical Effectiveness and Safety of Trastuzumab Deruxtecan (T-DXd) in Chinese Patients With HER2m NSCLC (RERUN)

Enrollment
150 pts
Location
China
Sponsor
Daiichi Sankyo
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NCT06833632
Recruiting

Detection of Circulating Tumour Cells, Spread Through Air Space in Patients With Lung Cancer

Enrollment
100 pts
Location
Italy
Sponsor
IRCCS Azienda Ospedaliero-Univ...
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NCT06755684 Phase 2
Recruiting

Neoadjuvant Befotertinib Combined Bevacizumab or Platinum-based Double Chemotherapy for Resectable Locally-advanced EGFR Mutation-positive Non-Small Cell Lung Cancer

Enrollment
60 pts
Location
China
Sponsor
Peng Zhang
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NCT05922345 Phase 3
Recruiting

Evaluation of the Efficacy and Safety of AL2846 Capsule Combined With TQB2450 Injection Compared to Docetaxel Injection in Advanced Non-small Cell Lung Cancer Patients Who Have Failed With Immunotherapy.

Enrollment
518 pts
Location
China
Sponsor
Chia Tai Tianqing Pharmaceutic...
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NCT05657873 Phase 2
Recruiting

A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)

Enrollment
68 pts
Location
United States
Sponsor
Memorial Sloan Kettering Cance...
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NCT05334277 Phase 2
Recruiting

Furmonertinib Monotherapy and Combination Therapy in Advanced EGFR Mutant NSCLC With Uncleared ctDNA

Enrollment
280 pts
Location
China
Sponsor
Sun Yat-sen University
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NCT05104788 Phase 2
Recruiting

A Study of Icotinib With Chemotherapy as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer

Enrollment
27 pts
Location
China
Sponsor
Peking University Cancer Hospi...
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NCT06268210 Phase 2
Recruiting

Neoadjuvant Lazertinib With or Without Chemotherapy for Patients With EGFR-mutated Resectable Non-small Cell Lung Cancer

Enrollment
160 pts
Location
South Korea
Sponsor
Yonsei University
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NCT05014464 Phase 2
Recruiting

ALK Tyrosine Kinase Inhibitors in ALK-rearranged Advanced Squamous Cell Carcinoma

Enrollment
90 pts
Location
China
Sponsor
Hunan Province Tumor Hospital
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NCT06969027 Phase 2
Recruiting

JS207Combined With Chemotherapy in First-line Treatment of Advanced NSCLC

Enrollment
84 pts
Location
China
Sponsor
Shanghai Junshi Bioscience Co....
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NCT05452005 Phase 1
Recruiting

Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer

Enrollment
20 pts
Location
United States
Sponsor
University of California, Davi...
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NCT05805319
Recruiting

Dietary Intervention for NSCLC Patients Treated With ICI

Enrollment
80 pts
Location
Canada
Sponsor
Centre hospitalier de l'Univer...
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NCT06047379 Phase 1, Phase 2
Recruiting

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Enrollment
134 pts
Location
United States
Sponsor
Neonc Technologies, Inc.
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NCT06123754 Phase 3
Recruiting

Phase III Study of Envafolimab Versus Placebo Plus Chemotherapy in Resectable Stage III NSCLC

Enrollment
390 pts
Location
China
Sponsor
3D Medicines (Sichuan) Co., Lt...
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NCT06896422 Phase 1
Recruiting

Randomized Trial of Glutathione With Anti-PD-1 and Chemotherapy in Advanced NSCLC

Enrollment
80 pts
Location
China
Sponsor
The First Affiliated Hospital ...
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NCT05076760 Phase 1
Recruiting

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Enrollment
40 pts
Location
United States
Sponsor
Memgen, Inc.
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NCT05654454 Phase 3
Recruiting

A Safety and Efficacy Study of Bevacizumab, Paclitaxel, Carboplatin Compared to Avastin® in Non-Small Cell Lung Cancer

Enrollment
620 pts
Location
Russia
Sponsor
Mabscale, LLC
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NCT02146170
Recruiting

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Enrollment
2,000 pts
Location
United States
Sponsor
National Cancer Institute (NCI...
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NCT06643000
Recruiting

Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis

Enrollment
60 pts
Location
China
Sponsor
Henan Cancer Hospital
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NCT07216105 Phase 1
Recruiting

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

Enrollment
113 pts
Location
United States
Sponsor
Fate Therapeutics
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NCT06486142 Phase 3
Recruiting

EGFR-mutated Lung Cancer in Randomized Investigator-Initiated Study

Enrollment
200 pts
Location
Sweden
Sponsor
Region Skane
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NCT06706713 Phase 2
Recruiting

Study of BEBT-109 in Subjects With EGFR Exon 20 Insertion Mutations Non-Small Cell Lung Cancer

Enrollment
200 pts
Location
China
Sponsor
BeBetter Med Inc
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NCT06275360 Phase 2
Recruiting

Repositioning Immunotherapy in VetArans With Lung Cancer

Enrollment
25 pts
Location
United States
Sponsor
VA Office of Research and Deve...
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NCT04322578 Phase 2
Recruiting

Crizotinb or Standard Chemotherapy in Met Exon 14 Skipping Advanced NSCLC

Enrollment
120 pts
Location
China
Sponsor
Hunan Province Tumor Hospital
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NCT06718309 Phase 2
Recruiting

Chemotherapy Plus Immunotherapy Combined With SBRT as Neoadjuvant Therapy for Patients With Resectable NSCLC

Enrollment
40 pts
Location
China
Sponsor
First People's Hospital of Han...
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NCT06902272 Phase 2
Recruiting

ctDNA to Predict Response to Chemo-Immunotherapy and Detect Minimal Residual Disease in Non-Small Cell Lung Cancer

Enrollment
30 pts
Location
United States
Sponsor
University of Miami
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NCT06789172 Phase 1
Recruiting

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Enrollment
166 pts
Location
United States, Austr...
Sponsor
Epkin
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NCT07261631 Phase 1
Recruiting

Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

Enrollment
180 pts
Location
Canada, France, Isra...
Sponsor
Novartis Pharmaceuticals
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NCT06124118 Phase 1
Recruiting

Tumor Treating Fields for Locally Advanced NSCLC

Enrollment
30 pts
Location
United States
Sponsor
University of Utah
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NCT06711900 Phase 3
Recruiting

A Study of SKB264 in Combination With Pembrolizumab Versus Chemotherapy in Combination With Pembrolizumab as First-Line Treatment for PD-L1 Negative Patients With Locally Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Enrollment
432 pts
Location
China
Sponsor
Sichuan Kelun-Biotech Biopharm...
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NCT05522660 Phase 3
Recruiting

Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer

Enrollment
180 pts
Location
Italy, Netherlands, ...
Sponsor
ETOP IBCSG Partners Foundation
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NCT06731907 Phase 2
Recruiting

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

Enrollment
90 pts
Location
United States, Chile...
Sponsor
Merck Sharp & Dohme LLC
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NCT06394674 Phase 2
Recruiting

High-dose Furmonertinib in the Treatment in Patients With Advanced, Metastatic NSCLC With Progressed After First- or Second-line Treatment With Osimertinib

Enrollment
84 pts
Location
China
Sponsor
Changhai Hospital
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NCT07161310
Recruiting

Urolithin A in Patients With Previously Untreated Solid Tumors Receiving Immune Checkpoint Inhibitors

Enrollment
45 pts
Location
Germany
Sponsor
Goethe University
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NCT06866717
Recruiting

Hybrid Prehabilitation Before Thoracic Surgery

Enrollment
38 pts
Location
France
Sponsor
ADIR Association
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NCT06103682
Recruiting

LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)

Enrollment
100 pts
Location
United States
Sponsor
University of California, Davi...
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NCT06311981 Phase 2
Recruiting

Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients

Enrollment
29 pts
Location
China
Sponsor
Jian Chen
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NCT06448754 Phase 2
Recruiting

Volrustomig Priming Regimens Exploratory Phase II Platform Study

Enrollment
180 pts
Location
United States, Canad...
Sponsor
AstraZeneca
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NCT05037331
Recruiting

Osimertinib for Advanced EGFR-positive NSCLC Patients

Enrollment
58 pts
Location
Singapore
Sponsor
National University Hospital, ...
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NCT07413757
Recruiting

CHOICE:Decision Factor of EGFR-TKI in Chinese IV NSCLC

Enrollment
590 pts
Location
China
Sponsor
AstraZeneca
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NCT07195695 Phase 3
Recruiting

Beamion LUNG-3: A Study to Test Whether Zongertinib Helps People With Surgically Removed, Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment

Enrollment
400 pts
Location
United States, Argen...
Sponsor
Boehringer Ingelheim
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NCT05241028 Phase 2
Recruiting

Adjuvant Therapy of Ensartinib in Stage IB-IIIA ALK-positive Non-small Cell Lung Cancer

Enrollment
80 pts
Location
China
Sponsor
Hebei Medical University Fourt...
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NCT04282044 Phase 1
Recruiting

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

Enrollment
60 pts
Location
United States
Sponsor
BioEclipse Therapeutics
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NCT07249372 Phase 2
Recruiting

DRP-104 in Patients With NFE2L2/KEAP1-altered Non-Small Cell Lung Cancer

Enrollment
37 pts
Location
United States
Sponsor
NYU Langone Health
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NCT07202364 Phase 2
Recruiting

A Study of YL202 in Patients With Advanced Solid Tumors

Enrollment
100 pts
Location
China
Sponsor
MediLink Therapeutics (Suzhou)...
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NCT05519293 Phase 1, Phase 2
Recruiting

Phase I/IIa Study of H002 in NSCLC With Active EGFR Mutation

Enrollment
76 pts
Location
United States
Sponsor
RedCloud Bio
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NCT05145244
Recruiting

Copenhagen Master Observational Trial

Enrollment
2,400 pts
Location
Denmark
Sponsor
Rigshospitalet, Denmark
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NCT06109454
Recruiting

Observation on the Therapeutic Effect of Huaier Granules in the Adjuvant Treatment of Non-small Cell Lung Cancer After Radical Surgery

Enrollment
240 pts
Location
China
Sponsor
Liaoning Cancer Hospital & Ins...
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NCT04193956
Recruiting

POINTING: Clinical Cohort Study of Patients With Melanoma and NSCLC Receiving Checkpoint Inhibitors

Enrollment
3,500 pts
Location
Netherlands
Sponsor
University Medical Center Gron...
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NCT05636969
Recruiting

Multimodal Prehabilitation in Patients with Lung Cancer Undergoing Neoadjuvant Therapy

Enrollment
60 pts
Location
Spain
Sponsor
Hospital Clinic of Barcelona
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NCT04585477 Phase 2
Recruiting

Adjuvant ctDNA-Adapted Personalized Treatment in Early Stage NSCLC (ADAPT-E)

Enrollment
80 pts
Location
United States
Sponsor
Stanford University
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NCT03476681 Phase 1, Phase 2
Recruiting

Study of NEO-201 in Solid Tumors Expansion Cohorts

Enrollment
121 pts
Location
United States
Sponsor
Precision Biologics, Inc
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NCT06646471 Phase 4
Recruiting

PROspective Master-protocol for Evaluation of Systemic THErapeutics in Elderly With Thoracic Malignancies

Enrollment
500 pts
Location
France
Sponsor
GFPC Investigation
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NCT07014202 Phase 2
Recruiting

Consolidation Radiotherapy vs. Observation in Oligoresidual Advanced Non-Small Cell Lung Cancer After Chemo-Immunotherapy

Enrollment
224 pts
Location
China
Sponsor
Cancer Institute and Hospital,...
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NCT06810544 Phase 1, Phase 2
Recruiting

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

Enrollment
191 pts
Location
United States
Sponsor
Tango Therapeutics, Inc.
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NCT06765109 Phase 3
Recruiting

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

Enrollment
450 pts
Location
United States, Argen...
Sponsor
Nuvalent Inc.
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NCT07485114
Recruiting

Association Between Galectin-3 Levels and Outcomes in Patients With Renal Cell Carcinoma, Transitional Cell Carcinoma , Non Small Cell Lung Cancer, and Hepatocellular Carcinoma, Treated With PD-1/PDL-1 Inhibitors

Enrollment
300 pts
Location
Israel
Sponsor
Daniel Keizman
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NCT06702826 Phase 2
Recruiting

Cadonilimab Combined With Stereotactic Radiotherapy as Second-line Treatment for Brain Metastases

Enrollment
20 pts
Location
China
Sponsor
Rongrong Zhou
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NCT06043817 Phase 1, Phase 2
Recruiting

First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

Enrollment
251 pts
Location
United States, Franc...
Sponsor
Pierre Fabre Medicament
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NCT05800340 Phase 2
Recruiting

Neoadjuvant Immunotherapy in Rare Mutations Localized NSCLC

Enrollment
30 pts
Location
China
Sponsor
Guangdong Provincial People's ...
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NCT06586515 Phase 1
Recruiting

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

Enrollment
630 pts
Location
United States, Canad...
Sponsor
Eli Lilly and Company
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NCT04585750 Phase 1, Phase 2
Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Enrollment
300 pts
Location
United States, Austr...
Sponsor
PMV Pharmaceuticals, Inc
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NCT05751018 Phase 2
Recruiting

Phase II Clinical Study of Pyrotinib in First-line Treatment of Primary HER2-amplified/Mutated Advanced Non-small Cell Lung Cancer

Enrollment
18 pts
Location
China
Sponsor
Peking Union Medical College H...
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NCT06235242
Recruiting

GT201 Injection in Combination with Teraplizumab Injection for Treatment of Patients with Non-small Cell Lung Cancer

Enrollment
20 pts
Location
China
Sponsor
Grit Biotechnology
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NCT07182682 Phase 3
Recruiting

A Phase 3 Study of Sunvozertinib Versus Placebo as Adjuvant Therapy in Patients With Early-Stage Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations or PACC Mutations After Radical Surgery

Enrollment
360 pts
Location
China
Sponsor
Dizal (Jiangsu) Pharmaceutical...
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NCT07183189 Phase 3
Recruiting

A Study of SHR-A2009 Combined With Aumolertinib Versus Aumolertinib for First-line Treatment in EGFR-mutated, Advanced or Metastatic NSCLC

Enrollment
576 pts
Location
China
Sponsor
Suzhou Suncadia Biopharmaceuti...
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NCT06281678 Phase 2
Recruiting

A Study of IBI363 in Subjects with Advanced Solid Malignancies

Enrollment
178 pts
Location
United States
Sponsor
Innovent Biologics (Suzhou) Co...
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NCT04401059 Phase 4
Recruiting

Synergistic Effect of Elemene Plus TKIs Compared With TKIs in EGFR-mutated Advanced NSCLC:Prospective Study

Enrollment
744 pts
Location
China
Sponsor
Tian Xie
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NCT05102110
Recruiting

Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.

Enrollment
450 pts
Location
United Kingdom
Sponsor
Origin Sciences
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NCT05627960 Phase 1
Recruiting

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

Enrollment
77 pts
Location
United States
Sponsor
A&G Pharmaceutical Inc.
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NCT07174908 Phase 3
Recruiting

A Phase 3 Study of IN10018 in Combination With D-1553 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation

Enrollment
400 pts
Location
China
Sponsor
InxMed (Shanghai) Co., Ltd.
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NCT07362940 Phase 1, Phase 2
Recruiting

A Phase Ⅰ/Ⅱa Clinical Study of GEN-725 in Combination With Dositinib

Enrollment
110 pts
Location
China
Sponsor
Henan Genuine Biotech Co., Ltd...
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NCT04322890 Phase 2
Recruiting

Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation

Enrollment
6,000 pts
Location
China
Sponsor
Hunan Province Tumor Hospital
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