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esophageal squamous cell carcinoma

Total Trials
10
Recruiting Now
10
Trial Phases
Phase 2, Phase 3, Phase 1

ClinicalMetric tracks all active clinical trials for esophageal squamous cell carcinoma sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — esophageal squamous cell carcinoma Clinical Trials

How many clinical trials are currently recruiting for esophageal squamous cell carcinoma?
ClinicalMetric currently tracks 10 actively recruiting clinical trials for esophageal squamous cell carcinoma, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 10. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for esophageal squamous cell carcinoma?
esophageal squamous cell carcinoma research spans Phase 1 (1 trial), Phase 2 (3 trials), Phase 3 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a esophageal squamous cell carcinoma clinical trial?
Eligibility criteria for esophageal squamous cell carcinoma trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
1
Phase 2
3
Phase 3
3
Top Sponsors
Zhejiang Cancer Hospital 1 trial
Cofactor Genomics, Inc. 1 trial
Renmin Hospital of Wuhan University 1 trial
Plexium, Inc. 1 trial
Daiichi Sankyo 1 trial

Recruiting Clinical Trials

NCT05507411 Phase 2
Recruiting
Watch and Wait for NeoAdjuvant Concurrent Radiochemotherapy Combined With Camrelizumab in Patients With Resectable ESCC
Enrollment
100 pts
Location
China
Sponsor
Zhejiang Cancer Hospital
View Trial →
NCT04510129
Recruiting
A Multicenter Cancer Biospecimen Collection Study
Enrollment
1,650 pts
Location
United States
Sponsor
Cofactor Genomics, Inc.
View Trial →
NCT05919030 Phase 3
Recruiting
A Study of Chemoradiation in Combination with Tislelizumab As First Line Treatment in Participants with Advanced Esophageal Squamous Cell Carcinoma
Enrollment
155 pts
Location
China
Sponsor
Renmin Hospital of Wuhan Unive...
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NCT07284186 Phase 1
Recruiting
First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors
Enrollment
155 pts
Location
United States
Sponsor
Plexium, Inc.
View Trial →
NCT06644781 Phase 3
Recruiting
A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)
Enrollment
510 pts
Location
United States, Belgi...
Sponsor
Daiichi Sankyo
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NCT06122493 Phase 2
Recruiting
Optimization of Treatment Strategy for Unresectable cN3 Esophageal Squamous Cell Carcinoma
Enrollment
48 pts
Location
China
Sponsor
Ruijin Hospital
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NCT06561178
Recruiting
Individualized Tumor-Informed CtDNA Analysis for Monitoring Postoperative Recurrence in ESCC (NEOCRTEC2401)
Enrollment
50 pts
Location
China
Sponsor
Sun Yat-Sen University Cancer ...
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NCT06190782 Phase 3
Recruiting
Local Therapy for Oligometastatic ESCC Patients Treated With PD-1 Inhibitor
Enrollment
354 pts
Location
China
Sponsor
Fudan University
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NCT05563766 Phase 2
Recruiting
A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer
Enrollment
78 pts
Location
United States
Sponsor
VA Office of Research and Deve...
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NCT07088354
Recruiting
Deep Learning Model Predicts Pathological Complete Response of Esophageal Squamous Cell Carcinoma Following Neoadjuvant Immunochemotherapy
Enrollment
300 pts
Location
China
Sponsor
Tongji Hospital
View Trial →

Related Conditions

esophageal adenocarcinoma (2) cancer of head and neck (1) lung cancer nonsmall cell (1) small cell lung cancer (1) urothelial carcinoma (1) gastroesophageal junction adenocarcinoma (1) cervical cancer (1) triple negative breast cancer (1) hepatocellular carcinoma (1) renal cell carcinoma (1) colorectal cancer (1) gastric adenocarcinoma (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: September 2026  ·  Data Methodology