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esophageal squamous cell carcinoma

Total Trials
18
Recruiting Now
18
Trial Phases
Phase 2, Phase 3, Phase 1

ClinicalMetric tracks all active clinical trials for esophageal squamous cell carcinoma sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — esophageal squamous cell carcinoma Clinical Trials

How many clinical trials are currently recruiting for esophageal squamous cell carcinoma?
ClinicalMetric currently tracks 18 actively recruiting clinical trials for esophageal squamous cell carcinoma, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 18. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for esophageal squamous cell carcinoma?
esophageal squamous cell carcinoma research spans Phase 1 (2 trials), Phase 2 (10 trials), Phase 3 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a esophageal squamous cell carcinoma clinical trial?
Eligibility criteria for esophageal squamous cell carcinoma trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
2
Phase 2
10
Phase 3
2
Top Sponsors
Shanghai Zhongshan Hospital 2 trials
The First Affiliated Hospital with Nanjing Medical University 2 trials
Tongji Hospital 2 trials
Anhui Provincial Hospital 2 trials
BeOne Medicines 1 trial

Recruiting Clinical Trials

NCT05740995
Recruiting
Neoadjuvant Anti-PD-1 Plus Chemotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma
Enrollment
40 pts
Location
China
Sponsor
Shanghai Zhongshan Hospital
View Trial →
NCT06988956 Phase 2
Recruiting
Nimotuzumab Plus Definite Chemoradiotherapy(dCRT) in Elderly Patients With Esophageal Squamous Cell Carcinoma
Enrollment
95 pts
Location
China
Sponsor
The First Affiliated Hospital ...
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NCT07554521 Phase 2
Recruiting
A Study to Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United States
Enrollment
30 pts
Location
United States
Sponsor
BeOne Medicines
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NCT07699185 Phase 2
Recruiting
Neoadjuvant Cardonilizumab Combined With Neoadjuvant Chemoradiotherapy Can Resect Locally Advanced Esophageal Squamous Cell Carcinoma
Enrollment
336 pts
Location
China
Sponsor
Tongji Hospital
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NCT05252078 Phase 2
Recruiting
Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients
Enrollment
30 pts
Location
China
Sponsor
Jiangxi Provincial Cancer Hosp...
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NCT06190782 Phase 3
Recruiting
Local Therapy for Oligometastatic ESCC Patients Treated With PD-1 Inhibitor
Enrollment
354 pts
Location
China
Sponsor
Fudan University
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NCT06329869 Phase 2
Recruiting
Sacituzumab Govitecan for Advanced Esophageal Squamous Cell Carcinoma
Enrollment
35 pts
Location
Taiwan
Sponsor
National Taiwan University Hos...
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NCT06602843
Recruiting
Neoadjuvant Chemoimmunotherapy Followed by Surgery and Postoperative Radioimmunotherapy
Enrollment
70 pts
Location
China
Sponsor
Anhui Provincial Hospital
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NCT07088354
Recruiting
Deep Learning Model Predicts Pathological Complete Response of Esophageal Squamous Cell Carcinoma Following Neoadjuvant Immunochemotherapy
Enrollment
300 pts
Location
China
Sponsor
Tongji Hospital
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NCT07505186 Phase 2
Recruiting
Camrelizumab, Chemotherapy and Ivarmacitinib in Patients With Resectable Esophageal Squamous Cell Carcinoma
Enrollment
45 pts
Location
China
Sponsor
Second Affiliated Hospital, Zh...
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NCT07016724 Phase 2
Recruiting
Neoadjuvant Radiochemotherapy Combined With Cadonilizumab for Local Advanced Esophageal Squamous Cell Cancer
Enrollment
208 pts
Location
China
Sponsor
The First Affiliated Hospital ...
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NCT06408584
Recruiting
Short-course Hypofractionated Radiotherapy in Combination With Raltitrexed and Tislelizumab
Enrollment
25 pts
Location
China
Sponsor
Anhui Provincial Hospital
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NCT07858630
Recruiting
Radiotherapy Target Volume Delineation in Locally Advanced Esophageal Cancer in the Immunotherapy Era
Enrollment
500 pts
Location
China
Sponsor
Cancer Institute and Hospital,...
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NCT06084481 Phase 1
Recruiting
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
Enrollment
325 pts
Location
United States, Austr...
Sponsor
AbbVie
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NCT06637163 Phase 2
Recruiting
Benmelstobart Combined With Radiochemotherapy as Neoadjuvant Treatment Iin ESCC
Enrollment
100 pts
Location
China
Sponsor
Shanghai Zhongshan Hospital
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NCT07437898 Phase 2
Recruiting
Neoadjuvant Adebrelimab Plus Chemotherapy for Esophageal Cancer: A Clinical Study
Enrollment
42 pts
Location
China
Sponsor
The Affiliated Hospital of Put...
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NCT05319730 Phase 1, Phase 2
Recruiting
A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
Enrollment
230 pts
Location
United States, Brazi...
Sponsor
Merck Sharp & Dohme LLC
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NCT06563869 Phase 3
Recruiting
Sintilimab With Chemotherapy Plus PEG-rhG-GSF for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma
Enrollment
40 pts
Location
China
Sponsor
The First Affiliated Hospital ...
View Trial →

Related Conditions

neoadjuvant chemoimmunotherapy (1) advanced unresectable gastric adenocarcinoma (1) advanced gastroesophageal adenocarcinoma (1) esophageal neoplasms (1) esophageal diseases (1) gastrointestinal neoplasms (1) gastrointestinal diseases (1) digestive system neoplasms (1) digestive system diseases (1) neoplasms by site (1) neoplasms by histologic type (1) neoplasms squamous cell (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology