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esophageal squamous cell carcinoma

Total Trials
17
Recruiting Now
17
Trial Phases
Phase 2, Phase 1, Phase 3

ClinicalMetric tracks all active clinical trials for esophageal squamous cell carcinoma sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — esophageal squamous cell carcinoma Clinical Trials

How many clinical trials are currently recruiting for esophageal squamous cell carcinoma?
ClinicalMetric currently tracks 17 actively recruiting clinical trials for esophageal squamous cell carcinoma, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 17. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for esophageal squamous cell carcinoma?
esophageal squamous cell carcinoma research spans Phase 1 (5 trials), Phase 2 (10 trials), Phase 3 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a esophageal squamous cell carcinoma clinical trial?
Eligibility criteria for esophageal squamous cell carcinoma trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
5
Phase 2
10
Phase 3
3
Top Sponsors
Nanfang Hospital, Southern Medical University 1 trial
Seagen, a wholly owned subsidiary of Pfizer 1 trial
Tianjin Medical University Cancer Institute and Hospital 1 trial
Tongji Hospital 1 trial
Shanghai Zhongshan Hospital 1 trial

Recruiting Clinical Trials

NCT06885814 Phase 2
Recruiting
Efficacy and Safety of Adebrelimab Combined With Chemoradiotherapy in Patients With Unresectable Locally Advanced or Postoperative Recurrent Esophageal Squamous Cell Carcinoma
Enrollment
30 pts
Location
China
Sponsor
Nanfang Hospital, Southern Med...
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NCT04389632 Phase 1
Recruiting
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
Enrollment
1,006 pts
Location
United States, Franc...
Sponsor
Seagen, a wholly owned subsidi...
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NCT04807673 Phase 3
Recruiting
Pembrolizumab Plus Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiotherapy for Locally Advanced ESCC (KEYSTONE-002)
Enrollment
342 pts
Location
China
Sponsor
Tianjin Medical University Can...
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NCT07088354
Recruiting
Deep Learning Model Predicts Pathological Complete Response of Esophageal Squamous Cell Carcinoma Following Neoadjuvant Immunochemotherapy
Enrollment
300 pts
Location
China
Sponsor
Tongji Hospital
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NCT07266493 Phase 2
Recruiting
Efficacy and Safety of Neoadjuvant Envafolimab Combined With Albumin-bound Paclitaxel and Carboplatin for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma
Enrollment
26 pts
Location
China
Sponsor
Shanghai Zhongshan Hospital
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NCT07385001 Phase 1, Phase 2
Recruiting
A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC
Enrollment
45 pts
Location
China
Sponsor
Tang-Du Hospital
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NCT06780111 Phase 1, Phase 2
Recruiting
Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)
Enrollment
298 pts
Location
United States, Brazi...
Sponsor
Merck Sharp & Dohme LLC
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NCT06056336 Phase 2
Recruiting
Perioperative Tislelizumab Plus Chemotherapy for Resectable Thoracic Oesophageal Squamous Cell Carcinoma
Enrollment
73 pts
Location
China
Sponsor
Guo Xufeng
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NCT06747585 Phase 1, Phase 2
Recruiting
A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors
Enrollment
170 pts
Location
United States, Franc...
Sponsor
Alentis Therapeutics AG
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NCT06971848
Recruiting
Evaluation of Skin Tests in Biotherapy Allergies
Enrollment
70 pts
Location
France
Sponsor
University Hospital, Angers
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NCT05252078 Phase 2
Recruiting
Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients
Enrollment
30 pts
Location
China
Sponsor
Jiangxi Provincial Cancer Hosp...
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NCT04009265 Phase 3
Recruiting
Study Compare Adjuvant Chemotherapy, Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma
Enrollment
819 pts
Location
China
Sponsor
Fujian Medical University Unio...
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NCT07519486 Phase 2
Recruiting
Intensive Nutritional Support in Conversion Therapy for Locally Advanced Unresectable ESCC
Enrollment
118 pts
Location
China
Sponsor
Sichuan University
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NCT04138212 Phase 3
Recruiting
Neoadjuvant Chemotherapy Versus Neoadjuvant Chemoradiotherapy for Resectable Locally Advanced Esophageal Cancer (HCHTOG1903)
Enrollment
456 pts
Location
China
Sponsor
Henan Cancer Hospital
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NCT03964753 Phase 2
Recruiting
Neoadjuvant Therapy With Nab-paclitaxel and Cisplatin for Locally Advanced Esophageal Squamous Cell Carcinoma
Enrollment
202 pts
Location
China
Sponsor
Hebei Medical University Fourt...
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NCT07152678 Phase 2
Recruiting
Brachytherapy With Radiotherapy and Immunotherapy: Guided HDR Trial in Esophageal Squamous Cell Carcinoma
Enrollment
60 pts
Location
Taiwan
Sponsor
National Taiwan University Hos...
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NCT07217171 Phase 1
Recruiting
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
Enrollment
160 pts
Location
United States
Sponsor
EvolveImmune United, Inc
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology