Medical Condition

ovarian cancer

Total Trials

50

Recruiting Now

50

Trial Phases

Phase 2, Phase 1, Phase 2, Phase 1

Ovarian cancer trials are shaped by the central role of BRCA1/2 mutation status and homologous recombination deficiency (HRD) in predicting response to PARP inhibitors β€” now standard maintenance therapy after first-line platinum-based chemotherapy for BRCA-mutated and HRD-positive disease. Despite PARP inhibitor approvals, platinum-resistant and BRCA wild-type advanced ovarian cancer remains a major unmet need driving frontline clinical research.

Active research includes next-generation PARP inhibitor combinations with anti-angiogenic agents and immune checkpoint inhibitors, mirvetuximab soravtansine (ADC targeting folate receptor alpha) in platinum-resistant disease, niraparib dose optimization, and VEGF/angiopoietin bispecific antibodies. Trials also evaluate intraperitoneal and heated intraperitoneal approaches for recurrent disease.

Most ovarian cancer trials require germline BRCA testing and often somatic tumor HRD testing; prior platinum therapy and number of prior lines determine eligibility for many studies.

Frequently Asked Questions — ovarian cancer Clinical Trials

How many clinical trials are currently recruiting for ovarian cancer?

ClinicalMetric currently tracks 50 actively recruiting clinical trials for ovarian cancer, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 50. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for ovarian cancer?

ovarian cancer research spans Phase 1 (20 trials), Phase 2 (16 trials), Phase 3 (5 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a ovarian cancer clinical trial?

Eligibility criteria for ovarian cancer trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 3

Phase 4

Top Sponsors

M.D. Anderson Cancer Center 5 trials

AstraZeneca 2 trials

Institut du Cancer de Montpellier - Val d'Aurelle 2 trials

Oncoinvent Solutions AS 1 trial

Korea University Guro Hospital 1 trial

ovarian cancer

Frequently Asked Questions — ovarian cancer Clinical Trials

Recruiting Clinical Trials

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