Clinical Trial Research Guides & Intelligence 2026

Independent research guides, expert analysis, and 10,000+ live recruiting trials — sourced daily from ClinicalTrials.gov. Free access for patients, caregivers, and researchers.

Medical Disclaimer: ClinicalMetric is an informational platform only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendation. Always consult a qualified healthcare professional before making any medical decision or enrolling in a clinical trial. Full disclaimer →

◆ FEATURED RESEARCH GUIDE NEW By the ClinicalMetric Editorial Team · 2026
Immuno-Oncology  ·  IN-DEPTH GUIDE
Bispecific Antibodies in Cancer Clinical Trials 2026: Six Approvals, T-Cell Engagers, and the Solid Tumor Question
Six bispecific antibodies are FDA-approved. Teclistamab shows 63% ORR in triple-class refractory myeloma. Glofitamab achieves complete responses in DLBCL. The solid tumor pipeline and what step-up dosing solved.
Read Full Guide →
AI & Technology AI-Discovered Drugs in Human Trials 2026: INS018_055, Recursion, and What AI Actually Contributes to Drug Development Insilico Medicine's INS018_055 is the first drug designed entirely by AI in Phase 2 clinical trials. What AI drug discovery actually means, what the data show, and where the realistic limits are. Read guide → Diagnostics Liquid Biopsy in Clinical Trials 2026: ctDNA, MRD, and Grail's Multi-Cancer Detection Data Liquid biopsy has moved from exploratory biomarker to approved companion diagnostic and trial endpoint. The GALAXY MRD data, Grail PATHFINDER, and ctDNA-guided treatment in early breast cancer. Read guide → Cell Therapy TIL and NK Cell Therapy Clinical Trials 2026: Amtagvi Approved, iPSC-NK Pipeline, and the Solid Tumor Frontier Amtagvi (lifileucel) became the first TIL therapy FDA-approved for melanoma in 2024. NK cell therapy from iPSC platforms enters Phase 2. What the C-144-01 data showed. Read guide → Metabolic Next-Generation Weight Loss Drug Trials 2026: Retatrutide, Orforglipron, CagriSema, and Beyond GLP-1 Tirzepatide achieved 22.5% weight loss. Retatrutide hit 24% in Phase 2. Oral GLP-1s are entering Phase 3. What the trial data actually show and what distinguishes each mechanism. Read guide → Nuclear Medicine Radiopharmaceutical Cancer Trials 2026: Lutetium-177, Actinium-225, and the Targeted Nuclear Medicine Pipeline Pluvicto and Lutathera are approved. Actinium-225 alpha emitters are entering Phase 3. How targeted radiopharmaceuticals work, what the VISION and NETTER-1 data showed, and the 2026 pipeline. Read guide → Mental Health Psilocybin and Psychedelic Therapy Trials in 2026: What the Clinical Data Actually Show Psilocybin has FDA Breakthrough Therapy designation for treatment-resistant depression. The Phase 2b data from COMP360 and the Phase 3 design challenges that follow. Read guide →
VIEW ALL 117 RESEARCH GUIDES →

UNDERSTANDING CLINICAL TRIALS

What Is a Clinical Trial?

A clinical trial is a research study conducted in people to evaluate a medical intervention — a drug, device, procedure, or behavioral change. All trials are registered on ClinicalTrials.gov before enrollment begins, as required by U.S. law (FDAAA 801). Trials are classified by phase: Phase 1 tests safety in small groups, Phase 2 tests efficacy, Phase 3 compares to existing treatments in large populations, and Phase 4 monitors long-term effects after approval.

Read full guide →
Who Can Participate?

Every trial defines inclusion and exclusion criteria — the specific requirements a participant must meet. Common factors include age range, diagnosis, disease stage, prior treatments, and current medications. Eligibility criteria exist to protect patient safety and ensure valid scientific results. You can review the full criteria for any trial on its ClinicalTrials.gov registry page before contacting the study team.

Read eligibility guide →
Are Participants Paid?

Compensation varies widely by trial type, duration, and sponsor. Phase 1 trials (healthy volunteers) often pay $1,000–$5,000 for inpatient stays. Later-phase trials for patients with specific conditions typically reimburse travel and time costs rather than paying a flat fee. FDA guidance requires that payment not be so high as to be coercive. Always review the informed consent document for specific payment terms before enrolling.

Read compensation guide →

POPULAR RESEARCH GUIDES

ALL 117 GUIDES →
Guide How to Join a Clinical Trial Oncology Cancer Clinical Trials 2026 Process Eligibility Criteria Explained Patients Clinical Trial Pay & Compensation Neurology Alzheimer's Trials 2026 Research Phase 1 vs Phase 3 Trials Timeline How Long Do Trials Take? Basics What Is a Clinical Trial?

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🔬 Cancer💉 Diabetes🧠 Alzheimer's💬 Depression❤️ Heart Disease🧬 Parkinson's🫀 Multiple Sclerosis🔭 Leukemia🦠 COVID-19🩺 HIV/AIDS
Editorial Standards All content reviewed by the ClinicalMetric Editorial Team — specialists in clinical research, medical data, and trial protocol analysis.
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What Are Clinical Trials?

Clinical trials are carefully designed research studies that evaluate new medical treatments, drugs, devices, or behavioral interventions in human volunteers who meet defined eligibility criteria. These studies follow a strict scientific protocol approved by an independent ethics board before any recruiting of participants begins.

Live recruiting studies listed on ClinicalTrials.gov represent the most current opportunities for patients and healthy volunteers to participate in cutting-edge medical research across hundreds of conditions worldwide. ClinicalMetric organizes these studies so researchers, patients, and healthcare professionals can find relevant trials quickly.

How to Find the Right Trial

Finding the right clinical trial begins with identifying your condition, location preferences, and the phase of research you are comfortable joining. Earlier phases carry more uncertainty while later phases involve well-characterized interventions already studied in many participants.

Each trial listing includes eligibility criteria specifying the required age range, diagnosis, prior treatment history, and any exclusion factors. Reviewing these details carefully before contacting the study team saves time for everyone involved in the screening process.

Understanding Trial Phases

Clinical trials progress through four standardized phases. Phase 1 studies enroll 20–80 participants primarily to evaluate safety and dosing. Phase 2 expands to 100–300 participants and tests therapeutic effect. Phase 3 compares the new intervention against standard-of-care treatments across thousands of participants. Phase 4 studies occur after regulatory approval and monitor long-term safety in the general population.

FREQUENTLY ASKED QUESTIONS

What is ClinicalMetric? +

ClinicalMetric is an independent clinical trial intelligence platform tracking 400,000+ active clinical trials worldwide, sourced daily from ClinicalTrials.gov (NIH/NLM). It provides condition-based filtering, phase breakdowns, eligibility summaries, and sponsor data to help patients, caregivers, and researchers find relevant studies.

Is ClinicalMetric affiliated with NIH, the FDA, or any pharmaceutical company? +

No. ClinicalMetric is an independent, privately operated platform. We are not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. We do not recruit for trials or receive referral fees from trial sponsors.

How do I join a clinical trial? +

To join a trial, review the eligibility criteria on the trial's detail page — including age range, diagnosis requirements, and exclusion factors. Then contact the study coordinator using the information listed on ClinicalTrials.gov. Your physician can also review your case and provide a referral to a specific study.

Is information on ClinicalMetric medical advice? +

No. All information on ClinicalMetric is for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here. Always consult a qualified healthcare professional before considering trial participation.

How often is clinical trial data updated? +

Trial data is sourced from ClinicalTrials.gov and refreshed daily. ClinicalMetric uses a multi-tier caching system to serve current data while maintaining fast, globally distributed performance.

Latest Research Intelligence

View all 117 guides →
Immuno-Oncology
Bispecific Antibodies in Cancer Clinical Trials 2026: Six Approvals, T-Cell Engagers, and the Solid Tumor Question
Six bispecific antibodies are FDA-approved. Teclistamab shows 63% ORR in triple-class refractory myeloma. Glofitamab achieves complete responses in DLBCL. The solid tumor pipeline and what step-up dosing solved.
Read guide →
AI & Technology
AI-Discovered Drugs in Human Trials 2026: INS018_055, Recursion, and What AI Actually Contributes to Drug Development
Insilico Medicine's INS018_055 is the first drug designed entirely by AI in Phase 2 clinical trials. What AI drug discovery actually means, what the data show, and where the realistic limits are.
Read guide →
Diagnostics
Liquid Biopsy in Clinical Trials 2026: ctDNA, MRD, and Grail's Multi-Cancer Detection Data
Liquid biopsy has moved from exploratory biomarker to approved companion diagnostic and trial endpoint. The GALAXY MRD data, Grail PATHFINDER, and ctDNA-guided treatment in early breast cancer.
Read guide →
Cell Therapy
TIL and NK Cell Therapy Clinical Trials 2026: Amtagvi Approved, iPSC-NK Pipeline, and the Solid Tumor Frontier
Amtagvi (lifileucel) became the first TIL therapy FDA-approved for melanoma in 2024. NK cell therapy from iPSC platforms enters Phase 2. What the C-144-01 data showed.
Read guide →
Metabolic
Next-Generation Weight Loss Drug Trials 2026: Retatrutide, Orforglipron, CagriSema, and Beyond GLP-1
Tirzepatide achieved 22.5% weight loss. Retatrutide hit 24% in Phase 2. Oral GLP-1s are entering Phase 3. What the trial data actually show and what distinguishes each mechanism.
Read guide →
Nuclear Medicine
Radiopharmaceutical Cancer Trials 2026: Lutetium-177, Actinium-225, and the Targeted Nuclear Medicine Pipeline
Pluvicto and Lutathera are approved. Actinium-225 alpha emitters are entering Phase 3. How targeted radiopharmaceuticals work, what the VISION and NETTER-1 data showed, and the 2026 pipeline.
Read guide →
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology