NCT05557877 Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer
| NCT ID | NCT05557877 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | Mayo Clinic |
| Condition | Breast Carcinoma |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2023-03-09 |
| Primary Completion | 2027-01-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 60 participants in total. It began in 2023-03-09 with a primary completion date of 2027-01-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This phase II trial tests whether low-dose aspirin can affect markers of inflammation in postpartum (after childbirth) women planning to have a breast biopsy. Chronic inflammation may increase the risk of postpartum related breast cancer. Low-dose aspirin is a non-steroidal anti-inflammatory drug. Giving low-dose aspirin may affect markers of inflammation in blood and tissue and may prevent postpartum related breast cancer.
Eligibility Criteria
Inclusion Criteria: * PRE-REGISTRATION: Age \>= 18 years and =\< 45 years of age * PRE-REGISTRATION: Willingness to provide mandatory tissue specimens for correlative research at two timepoints. * PRE-REGISTRATION: Had a live birth =\< 10 years prior to pre-registration * PRE-REGISTRATION: Pre-menopausal according to patient report and/or clinical determination * PRE-REGISTRATION: Provide written informed consent * PRE-REGISTRATION: Ability to complete questionnaire(s) by themselves or with assistance * PRE-REGISTRATION: Willingness to provide mandatory blood and urine specimens for correlative research * REGISTRATION: Age \>= 18 years and =\< 45 years of age * REGISTRATION: Registration for this study must be completed either =\< one (1) year after the qualifying pre-registration biopsy is performed for this study or =\< one (1) year after collection of the archived tissue (for those who did not have a pre-registration biopsy performed after pre-registration for this study) * REGISTRATION: Hemoglobin \>= 9.0 g/dL (obtained =\< 90 days prior to registration) * REGISTRATION: Platelet count \>= 100,000/mm\^3 (obtained =\< 90 days prior to registration * REGISTRATION: Serum creatinine =\< 2.0 mg/dl (obtained =\< 90 days prior to registration) * REGISTRATION: Negative pregnancy test done =\< 15 days prior to registration * REGISTRATION: Willing to use contraception while on treatment * REGISTRATION: Provide written informed consent * REGISTRATION: Ability to complete questionnaire(s) by themselves or with assistance * REGISTRATION: Willingness to provide mandatory blood and urine specimens for correlative research * REGISTRATION: Willingness to provide mandatory tissue specimens for correlative research * REGISTRATION: Willing to return to enrolling institution for follow-up (during the active monitoring phase of the study) Exclusion Criteria: * PRE-REGISTRATION: History of breast cancer including ductal breast carcinoma in situ (DCIS) * PRE-REGISTRATION: Received systemic treatment for any other cancer at any time * PRE-REGISTRATION: Currently taking aspirin or other non-steroidal anti-inflammatory drugs (NSAIDS) (no doses within =\< 5 days prior to pre-registration and no more than four doses within =\< 30 days prior to pre-registration) * PRE-REGISTRATION: Currently taking other agents for the prevention of breast cancer * PRE-REGISTRATION: Currently taking anticoagulants * PRE-REGISTRATION: Contraindication for aspirin use * PRE-REGISTRATION: Known or suspected active breast infection * REGISTRATION: Known DCIS or invasive cancer * REGISTRATION: No research tissue available from pre-registration biopsy or from archived tissue (collected =\< 12 months prior to pre-registration) * REGISTRATION: Currently taking aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) (NOTE: no doses within =\< 5 days prior to registration and no more than four doses within =\< 30 days prior to registration) * REGISTRATION: Co-morbid illnesses/conditions which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens * REGISTRATION: Any contraindication to aspirin use including but not limited to: * Bleeding disorders (e.g., hemophilia) * Stomach or intestinal bleeding =\< 6 months prior to registration * Known allergy to other non-steroidal anti-inflammatory drugs (NSAIDs) * REGISTRATION: Currently taking anticoagulants * REGISTRATION: Any prior or current malignancy requiring prior or current systemic therapy * REGISTRATION: Currently pregnant or planning to become pregnant in the next 90 days * REGISTRATION: Post-menopausal: * Prior bilateral surgical oophorectomy or * No menses for \> 1 year with estradiol levels within postmenopausal range, according to institutional standard * REGISTRATION: Known or suspected active breast infection
Contact & Investigator
Kathryn J. Ruddy, MD
PRINCIPAL INVESTIGATOR
Mayo Clinic in Rochester
Frequently Asked Questions
Who can join the NCT05557877 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 45 Years, studying Breast Carcinoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05557877 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT05557877 currently recruiting?
Yes, NCT05557877 is actively recruiting participants. Contact the research team at mayocliniccancerstudies@mayo.edu for enrollment information.
Where is the NCT05557877 trial being conducted?
This trial is being conducted at Scottsdale, United States, Jacksonville, United States, Indianapolis, United States, Rochester, United States and 1 additional location.
Who is sponsoring the NCT05557877 clinical trial?
NCT05557877 is sponsored by Mayo Clinic. The principal investigator is Kathryn J. Ruddy, MD at Mayo Clinic in Rochester. The trial plans to enroll 60 participants.