A Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of Intravenous Infusion of hUC-MSCs in Patients With AIS
Trial Parameters
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Brief Summary
This is a Phase IIa clinical trial with a three-arm design that utilizes randomization, double-blinding, and placebo control. The primary objective of this study is to evaluate the efficacy of single and multiple intravenous infusions of hUC-MSCs injection in patients with AIS. The secondary objective is to assess the safety and tolerability of single and multiple intravenous infusions of hUC-MSCs injection in patients with AIS. The exploratory objective is to investigate the pharmacokinetic and pharmacodynamic characteristics of hUC-MSCs injection in patients with AIS.
Eligibility Criteria
Inclusion Criteria: 1. Age 18 to 75 years, inclusive, regardless of gender. 2. Diagnosis of acute ischemic stroke (AIS). 3. Onset time ≤ 72 hours. 4. Anterior circulation cerebral infarction. 5. Modified Rankin Scale (mRS) score ≤ 1 before the onset of this stroke. 6. National Institutes of Health Stroke Scale (NIHSS) score between 8 and 20 (inclusive) at screening, and NIHSS item 1a (level of consciousness) score ≤ 1. 7. The subject or their legal guardian has signed the informed consent form. Exclusion Criteria: 1. Planned or already undergone thrombolysis or thrombectomy for this stroke. 2. History of epilepsy (excluding secondary epilepsy that does not currently require medication), Parkinson's disease, Alzheimer's disease, severe depression, or other diseases that the investigator deems would affect the subject's participation in the trial or the assessment of efficacy. 3. Presence of intracranial hemorrhagic disease (e.g., intracerebral hemorrhage, intraventricular hemorrhage, su