State NC
Clinical Trials in North Carolina
North Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in North Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 385 actively recruiting studies with North Carolina sites out of 385 registered in total. The busiest research areas in North Carolina are Breast Cancer, Ovarian Cancer, Systemic Lupus Erythematosus. Leading sponsors running trials in the state include Wake Forest University Health Sciences, Duke University, National Cancer Institute (NCI). By stage, North Carolina trials break down as Phase 1 (52), Phase 2 (90), Phase 3 (101), Phase 4 (15).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in North Carolina
Frequently Asked Questions — Clinical Trials in North Carolina
How many clinical trials are currently recruiting in North Carolina?
ClinicalMetric currently tracks 385 actively recruiting clinical trials with at least one location in North Carolina. The total number of registered studies—including active but not currently enrolling trials—is 385. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in North Carolina?
North Carolina hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Ovarian Cancer, Systemic Lupus Erythematosus, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout North Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in North Carolina?
To join a clinical trial in North Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in North Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in North Carolina
NCT04337580 Phase 2
Recruiting
Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer
Condition
Prostate Cancer
Enrollment
50 pts
Location
United States
Sponsor
Wake Forest University Health
NCT07325279 Phase 1
Recruiting
Nalmefene Implant in Healthy Subjects
Condition
Opioid Abuse and Addiction
Enrollment
24 pts
Location
United States
Sponsor
ReacX Pharmaceuticals, Inc.
NCT05489588 N/A
Recruiting
The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study
Condition
Venous Thromboses
Enrollment
165 pts
Location
United States
Sponsor
W.L.Gore & Associates
NCT07187973 Phase 1
Recruiting
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disea...
Condition
Sickle Cell Disease
Enrollment
24 pts
Location
United States
Sponsor
Disc Medicine, Inc
NCT05711394 Phase 3
Recruiting
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atog...
Condition
Episodic Migraine
Enrollment
450 pts
Location
United States, Belgium, Canada
Sponsor
AbbVie
NCT04994756 N/A
Recruiting
Stroke Thrombectomy and Aneurysm Registry
Condition
Stroke
Enrollment
40,000 pts
Location
United States, Canada, Germany
Sponsor
Medical University of South Ca
NCT06749457 Phase 1, Phase 2
Recruiting
A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase...
Condition
Staphylococcus Aureus
Enrollment
231 pts
Location
United States
Sponsor
AstraZeneca
NCT00345930 N/A
Recruiting
DILIN - Prospective Study
Condition
Liver Diseases
Enrollment
4,000 pts
Location
United States
Sponsor
Duke University
NCT04566328 Phase 3
Recruiting
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Mu...
Condition
Plasma Cell Myeloma
Enrollment
1,450 pts
Location
United States, Puerto Rico
Sponsor
ECOG-ACRIN Cancer Research Gro
NCT05147792 N/A
Recruiting
The CONFORM Pivotal Trial
Condition
Atrial Fibrillation
Enrollment
1,600 pts
Location
United States, Czechia, France
Sponsor
Conformal Medical, Inc
NCT05005975 Phase 3
Recruiting
Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-711...
Condition
EPP
Enrollment
301 pts
Location
United States, Australia, Belgium
Sponsor
Tanabe Pharma America, Inc.
NCT05762107 Phase 2
Recruiting
A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
Condition
Type 1 Diabetes Mellitus With Hypoglycemia
Enrollment
186 pts
Location
United States, Canada
Sponsor
Zucara Therapeutics Inc.
NCT07661056 Phase 3
Recruiting
Study to Determine if BHV-1300 is Effective and Safe in Adults With Graves' Dise...
Condition
Graves Disease
Enrollment
300 pts
Location
United States
Sponsor
Biohaven Therapeutics Ltd.
NCT07173751 Phase 3
Recruiting
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-N...
Condition
Breast Neoplasms
Enrollment
558 pts
Location
United States, Australia, Belgium
Sponsor
BioNTech SE
NCT06655246 Phase 1
Recruiting
A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gas...
Condition
Gastrointestinal Stromal Tumor (GIST)
Enrollment
157 pts
Location
United States
Sponsor
Kura Oncology, Inc.
NCT05638581 Phase 3
Recruiting
Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
Condition
Wounds and Injuries
Enrollment
1,100 pts
Location
United States
Sponsor
University of Alabama at Birmi
NCT07011719 Phase 3
Recruiting
Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients...
Condition
Metastatic Clear Cell Renal Cell Carcinoma
Enrollment
720 pts
Location
United States, Australia, Canada
Sponsor
Arcus Biosciences, Inc.
NCT07491172 Phase 1
Recruiting
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractor...
Condition
Cardiovascular
Enrollment
90 pts
Location
United States, Australia, New Zealand
Sponsor
CRISPR Therapeutics AG
NCT06244212 N/A
Recruiting
Topical Treatment for Atopic Dermatitis
Condition
Atopic Dermatitis
Enrollment
30 pts
Location
United States
Sponsor
Wake Forest University Health
NCT06143631 Phase 4
Recruiting
Prescription of Letrozole for Uterine Myoma
Condition
Leiomyoma, Uterine
Enrollment
140 pts
Location
United States
Sponsor
University of California, San
NCT06351345 Phase 2
Recruiting
129 Xenon Imaging in Patients Treated With Sotatercept
Condition
Pulmonary Hypertension
Enrollment
14 pts
Location
United States
Sponsor
Bastiaan Driehuys
NCT05712057 N/A
Recruiting
Neurostimulation Versus Therapy for Problems With Emotions
Condition
Emotion Regulation
Enrollment
240 pts
Location
United States
Sponsor
Duke University
NCT06960837 N/A
Recruiting
Ultrasound Simulation Case-based Workshop Implementation and Impact Assessment
Condition
Point-of-care Ultrasound
Enrollment
100 pts
Location
United States
Sponsor
Duke University
NCT06216548 N/A
Recruiting
E-PRIME For Children With Medical Complexity
Condition
Children With Medical Complexity
Enrollment
909 pts
Location
United States
Sponsor
Wake Forest University Health
NCT06679855 Phase 3
Recruiting
Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial
Condition
Post-ligation Cardiac Syndrome
Enrollment
316 pts
Location
United States
Sponsor
NICHD Neonatal Research Networ
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology