State NC
Clinical Trials in North Carolina
North Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in North Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 372 actively recruiting studies with North Carolina sites out of 372 registered in total. The busiest research areas in North Carolina are Breast Cancer, Heart Failure, Multiple Myeloma. Leading sponsors running trials in the state include Duke University, Wake Forest University Health Sciences, UNC Lineberger Comprehensive Cancer Center. By stage, North Carolina trials break down as Phase 1 (61), Phase 2 (94), Phase 3 (79), Phase 4 (12).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in North Carolina
Frequently Asked Questions — Clinical Trials in North Carolina
How many clinical trials are currently recruiting in North Carolina?
ClinicalMetric currently tracks 372 actively recruiting clinical trials with at least one location in North Carolina. The total number of registered studies—including active but not currently enrolling trials—is 372. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in North Carolina?
North Carolina hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Heart Failure, Multiple Myeloma, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout North Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in North Carolina?
To join a clinical trial in North Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in North Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in North Carolina
NCT05625659 N/A
Recruiting
Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breas...
Condition
Breast Cancer
Enrollment
2,032 pts
Location
United States, Canada
Sponsor
American College of Radiology
NCT06517056 N/A
Recruiting
Emovi 3D Knee Assessment Device Intervention for Operational Readiness
Condition
Patellofemoral Pain
Enrollment
180 pts
Location
United States
Sponsor
Womack Army Medical Center
NCT07817251 Phase 3
Recruiting
Research Study on How People With Type 2 Diabetes Tolerate Switching From Semagl...
Condition
Diabetes Mellitus, Type 2
Enrollment
210 pts
Location
United States
Sponsor
Novo Nordisk A/S
NCT05955261 Phase 2
Recruiting
A Study of Venetoclax in Combination With Conventional Chemotherapy in Pediatric...
Condition
Acute Myeloid Leukemia
Enrollment
70 pts
Location
United States
Sponsor
St. Jude Children's Research H
NCT07609394 N/A
Recruiting
Duchenne Electronic Health Record Study
Condition
Duchenne Muscular Dystrophy (DMD)
Enrollment
2,500 pts
Location
United States
Sponsor
The Duchenne Registry
NCT07507370 N/A
Recruiting
CARED : A Novel Rapid Treatment Paradigm for Depression
Condition
Major Depressive Disorder
Enrollment
30 pts
Location
United States
Sponsor
University of North Carolina,
NCT06767514 Phase 3
Recruiting
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patie...
Condition
Non-Small Cell Lung Cancer
Enrollment
780 pts
Location
United States, Belgium, Canada
Sponsor
Summit Therapeutics
NCT07116967 Phase 3
Recruiting
Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants Wit...
Condition
Plaque Psoriasis
Enrollment
3,040 pts
Location
United States, Argentina, Australia
Sponsor
Bristol-Myers Squibb
NCT05262907 N/A
Recruiting
Ventripoint Single Ventricle Study
Condition
Congenital Heart Disease
Enrollment
100 pts
Location
United States
Sponsor
Duke University
NCT06740630 Phase 3
Recruiting
A Study on the Immune Response and Safety of an Investigational Chickenpox Vacci...
Condition
Chickenpox
Enrollment
1,840 pts
Location
United States, Belgium, Colombia
Sponsor
GlaxoSmithKline
NCT07421700 Phase 1, Phase 2
Recruiting
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With...
Condition
Urothelial Cancer
Enrollment
132 pts
Location
United States, Australia, China
Sponsor
Pfizer
NCT07196644 Phase 2
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity in Participants ...
Condition
Solid Tumors Harboring MET Amplification
Enrollment
100 pts
Location
United States, Israel, Japan
Sponsor
AbbVie
NCT06118892 N/A
Recruiting
MISHA Post-Market Clinical Study
Condition
Osteo Arthritis Knee
Enrollment
120 pts
Location
United States
Sponsor
Moximed
NCT02735707 Phase 3
Recruiting
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acqu...
Condition
Respiratory Tract Diseases
Enrollment
20,000 pts
Location
United States, Australia, Belgium
Sponsor
UMC Utrecht
NCT07031336 N/A
Recruiting
Photon-counting CT in Chest Imaging
Condition
COPD (Chronic Obstructive Pulmonary Disease)
Enrollment
40 pts
Location
United States
Sponsor
Duke University
NCT07276711 N/A
Recruiting
CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material
Condition
Aortic Valve Stenosis
Enrollment
663 pts
Location
United States
Sponsor
EmStop Inc
NCT06868316 N/A
Recruiting
Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability
Condition
Ankle Sprains
Enrollment
100 pts
Location
United States
Sponsor
Danielle Torp
NCT07915609 Phase 3
Recruiting
A Study to Learn About Berobenatide Given Once Weekly in Adults With Knee Osteoa...
Condition
Obesity
Enrollment
756 pts
Location
United States
Sponsor
Pfizer
NCT06736574 Phase 3
Recruiting
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With S...
Condition
Heart Failure
Enrollment
1,800 pts
Location
United States, Canada, China
Sponsor
Cytokinetics
NCT07264790 Phase 1
Recruiting
Assessment of Topical Minoxidil on Intraoperative Flap Perfusion and Cutaneous F...
Condition
Breast Reconstruction
Enrollment
25 pts
Location
United States
Sponsor
Duke University
NCT05786417 Phase 4
Recruiting
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and...
Condition
Angina
Enrollment
741 pts
Location
United States
Sponsor
Yale University
NCT05700474 N/A
Recruiting
Enhancing Wellness Through Affirming Services and Education
Condition
HIV
Enrollment
200 pts
Location
United States
Sponsor
Duke University
NCT07084168 N/A
Recruiting
Multimedia Aid for Genetic Testing in Gynecologic Oncology
Condition
Ovary Cancer
Enrollment
30 pts
Location
United States
Sponsor
UNC Lineberger Comprehensive C
NCT03713268 N/A
Recruiting
Intraoperative OCT Guidance of Intraocular Surgery II
Condition
Macular Holes
Enrollment
262 pts
Location
United States
Sponsor
Duke University
NCT06066723 N/A
Recruiting
19F MRI in Healthy Children and Children With Mild Cystic Fibrosis Lung Disease
Condition
Cystic Fibrosis in Children
Enrollment
15 pts
Location
United States
Sponsor
University of North Carolina,
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology