State NC
Clinical Trials in North Carolina
North Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in North Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 406 actively recruiting studies with North Carolina sites out of 406 registered in total. The busiest research areas in North Carolina are Heart Failure, Breast Cancer, Advanced Solid Tumors. Leading sponsors running trials in the state include Duke University, Wake Forest University Health Sciences, AstraZeneca. By stage, North Carolina trials break down as Phase 1 (63), Phase 2 (113), Phase 3 (108), Phase 4 (17).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in North Carolina
Frequently Asked Questions — Clinical Trials in North Carolina
How many clinical trials are currently recruiting in North Carolina?
ClinicalMetric currently tracks 406 actively recruiting clinical trials with at least one location in North Carolina. The total number of registered studies—including active but not currently enrolling trials—is 406. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in North Carolina?
North Carolina hosts clinical trials across a broad range of medical conditions, including Heart Failure, Breast Cancer, Advanced Solid Tumors, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout North Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in North Carolina?
To join a clinical trial in North Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in North Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in North Carolina
NCT05920356 Phase 3
Recruiting
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab P...
Condition
Non-Small Cell Lung Cancer (NSCLC)
Enrollment
750 pts
Location
United States, Argentina, Australia
Sponsor
Amgen
NCT06667141 Phase 1
Recruiting
Phase 1 Study of ACR-2316 in Specific Advanced Solid Tumors
Condition
Specific Advanced Solid Tumors
Enrollment
100 pts
Location
United States
Sponsor
Acrivon Therapeutics
NCT05103254 N/A
Recruiting
Bempedoic Acid Pregnancy Surveillance Program
Condition
Pregnancy
Enrollment
20 pts
Location
United States
Sponsor
Esperion Therapeutics, Inc.
NCT06242795 Phase 4
Recruiting
Hypertonic Saline in NCFB
Condition
Bronchiectasis
Enrollment
20 pts
Location
United States
Sponsor
University of North Carolina,
NCT07167641 N/A
Recruiting
Caring for the Carer
Condition
Care Burden
Enrollment
60 pts
Location
United States
Sponsor
University of North Carolina,
NCT04775745 Phase 1
Recruiting
Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B...
Condition
CLL/SLL
Enrollment
60 pts
Location
United States
Sponsor
Newave Pharmaceutical Inc
NCT05076175 Phase 2, Phase 3
Recruiting
A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Mod...
Condition
Colitis, Ulcerative
Enrollment
120 pts
Location
United States, Australia, Belgium
Sponsor
Bristol-Myers Squibb
NCT06095128 Phase 4
Recruiting
A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)
Condition
Ulcerative Colitis
Enrollment
65 pts
Location
United States, Canada
Sponsor
Takeda
NCT07226271 N/A
Recruiting
Consumer Perceptions of Alcoholic Beverages
Condition
Health Behavior
Enrollment
1,500 pts
Location
United States
Sponsor
UNC Lineberger Comprehensive C
NCT05313165 N/A
Recruiting
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-St...
Condition
Critical Limb Ischemia
Enrollment
100 pts
Location
United States
Sponsor
LimFlow, Inc.
NCT06272045 N/A
Recruiting
Early Intervention to Promote Cardiovascular Health of Mothers and Children
Condition
Cardiovascular Health
Enrollment
6,618 pts
Location
United States
Sponsor
JHSPH Center for Clinical Tria
NCT06972719 N/A
Recruiting
Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy
Condition
BRCA1 Mutation
Enrollment
50 pts
Location
United States
Sponsor
Duke University
NCT06830265 N/A
Recruiting
Comparing Standard of Care Biopsy System to a Novel Biopsy Needle System by Comp...
Condition
Prostate Cancer Screening
Enrollment
200 pts
Location
United States
Sponsor
Uro-1 Medical
NCT07092566 Phase 3
Recruiting
R.E.C.K vs Exparel in Robotic Nephrectomy
Condition
Renal Carcinoma
Enrollment
170 pts
Location
United States
Sponsor
Wake Forest University Health
NCT05504837 Phase 1
Recruiting
A Study Assessing KB407 for the Treatment of Cystic Fibrosis
Condition
Cystic Fibrosis
Enrollment
20 pts
Location
United States
Sponsor
Krystal Biotech, Inc.
NCT06982677 N/A
Recruiting
Improving Outcomes in Early Menopause After Cancer
Condition
Early Menopause
Enrollment
117 pts
Location
United States
Sponsor
Duke University
NCT06218875 N/A
Recruiting
Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endopros...
Condition
AAA - Abdominal Aortic Aneurysm
Enrollment
2,000 pts
Location
United States, Australia, Austria
Sponsor
W.L.Gore & Associates
NCT04373057 Phase 1, Phase 2
Recruiting
Prebiotic Galacto-oligosaccharide and Acute GVHD
Condition
Acute GVHD
Enrollment
128 pts
Location
United States
Sponsor
University of Kansas Medical C
NCT07107737 N/A
Recruiting
Physician Engagement in EMS Transport Refusal Rates
Condition
Refusal of Transport
Enrollment
250 pts
Location
United States
Sponsor
Wake Forest University Health
NCT06975722 Phase 2
Recruiting
A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participant...
Condition
Ulcerative Colitis
Enrollment
99 pts
Location
United States, Australia, China
Sponsor
Sanofi
NCT07532265 Phase 2
Recruiting
A Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in...
Condition
Severe Asthma
Enrollment
512 pts
Location
United States
Sponsor
Kinaset Therapeutics Inc
NCT01904851 N/A
Recruiting
Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes
Condition
Peripheral Arterial Disease
Enrollment
14,000 pts
Location
United States
Sponsor
Baylor Research Institute
NCT06283966 Phase 3
Recruiting
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fum...
Condition
COPD (Chronic Obstructive Pulmonary Disease)
Enrollment
5,000 pts
Location
United States, Argentina, Australia
Sponsor
AstraZeneca
NCT05125302 Phase 3
Recruiting
Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets f...
Condition
Migraine
Enrollment
1,059 pts
Location
United States, Puerto Rico
Sponsor
AbbVie
NCT06554795 Phase 1, Phase 2
Recruiting
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
Condition
Solid Tumor, Adult
Enrollment
360 pts
Location
United States, Australia, China
Sponsor
DualityBio Inc.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology