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heart failure

Total Trials

81

Recruiting Now

81

Trial Phases

Phase 4, Phase 1, Phase 2

ClinicalMetric tracks all active clinical trials for heart failure sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — heart failure Clinical Trials

How many clinical trials are currently recruiting for heart failure?

ClinicalMetric currently tracks 81 actively recruiting clinical trials for heart failure, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 81. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for heart failure?

heart failure research spans Phase 1 (5 trials), Phase 2 (4 trials), Phase 3 (4 trials), Phase 4 (5 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a heart failure clinical trial?

Eligibility criteria for heart failure trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

5

Phase 2

4

Phase 3

4

Phase 4

5

Top Sponsors

Abbott Medical Devices 3 trials

University of Calgary 2 trials

Ottawa Heart Institute Research Corporation 1 trial

BiVACOR Inc. 1 trial

IRCCS San Raffaele Roma 1 trial

Recruiting Clinical Trials

LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY

Ottawa Heart Institute Researc...

BiVACOR® Total Artificial Heart Early Feasibility Study

Drug Management in Heart Failure

IRCCS San Raffaele Roma

NCT05672836 Phase 4

ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement

Duk-Woo Park, MD

VIrtual Care To Improve Outcomes and RecoverY From Heart Failure Hospitalization

Canada, Tunisia

Population Health Research Ins...

Targeted Artificial Intelligence Language mOdel Recommendations for Heart Failure (TAILOR-HF)

Brigham and Women's Hospital

Early Feasibility Study of the Edwards APTURE Transcatheter Shunt System

Edwards Lifesciences

Clinical Information System Impact on Hospitalized Patients With Chronic Disease

University of Calgary

Corheart 6: Long-term Cohort Study

China National Center for Card...

NCT07656454 Phase 1

A Study Understanding How Much CDR132L Enters the Bloodstream After Injection Under the Skin Compared to Injection Into a Vein in Healthy Participants

Novo Nordisk A/S

NCT06130059 Phase 2

Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation

University of Texas Southweste...

Metabolic Response to the Initiation of Heart Failure Therapy

Vojtech Melenovsky, MD, PhD

31P-MRS Myocardial Energetic Phenotyping and Prognosis Across the Cardiac Disease Spectrum

Chinese Academy of Medical Sci...

Voice-based Outcome Identification and Clinical Evaluation in Heart Failure

Promoting Palliative Care for People With Heart Failure

Yale University

Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)

Weill Medical College of Corne...

NCT07527156 Phase 4

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

Institute for Clinical and Exp...

NCT05700617 EARLY_Phase 1

Cardiac Power Output in Cardiogenic Shock Patients

University of Chicago

NCT07547540 Phase 1

A Study of LY3971297 in Participants With Heart Failure

United States, Japan...

Eli Lilly and Company

Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging

Fatebenefratelli Hospital

OBESE-HFpEF: Towards Preventing Obesity Related HFpEF

Zuyderland Medisch Centrum

NCT07304817 Phase 2

Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS)

University Medical Center Gron...

NCT06154044 Phase 2

Cell Therapy and Myocardial Recovery in Heart Failure Patients Undergoing Left Ventricular Assist Device Support

University Medical Centre Ljub...

Validation of the Prognostic Impact of a Retinal Photograph-based Cardiovascular Disease Risk Stratification System in de Novo HFrEF

Yonsei University

Electronic Register on Advanced Heart Failure and Transplantation di Cuore

IRCCS Azienda Ospedaliero-Univ...

NCT04396899 Phase 1, Phase 2

Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Tissue in Terminal Heart Failure

University Medical Center Goet...

NCT06736574 Phase 3

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

United States, Canad...

MediBeacon® Transdermal GFR System for the Evaluation of Kidney Function in Adults With Heart Failure

Promoting Well-being and Health in Heart Failure

Massachusetts General Hospital

Retrospective Prospective Multicentric Clinical Follow up of Patients After Being Treated With TricValve®

Austria, Belgium, Ge...

P+F Products + Features GmbH

HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

University of Kansas Medical C...

UIC Multi-Ethnic DCM Registry

University of Illinois Chicago

NORM-HF Pivotal Study

Foundry Innovation & Research ...

Efficacy of MitraCLip Vs. PASCAL for the TrEAtment of MitraL REgurgiTation in an All-comer Population

INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

CardioMEMS HF System Coverage With Evidence Development Study

Abbott Medical Devices

Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

United States, Canad...

NHS Greater Glasgow and Clyde

Cardiometabolic evalUation REgistry of Heart Failure

Ruijin Hospital

Assessing Systemic Circulation and LV Performance in Adults

University of Calgary

Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational Study

University Medical Center Ho C...

Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

West Virginia School of Osteop...

NCT06082063 Phase 3

Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes

Steno Diabetes Center Copenhag...

A Village Doctor-led Telehealth Supported Improvement of Outcomes of AF Patients With Heart Failure Due to Reduced or Preserved Ejection Fraction: The MIRACLE-AF 2 Heart Failure Management Trial (MIRACLE AF-HF)

Jiangsu Taizhou People's Hospi...

NCT06158698 Phase 3

CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine

Niguarda Hospital

Cardiac RadiothErapy For hEart faiLure

Universitaire Ziekenhuizen KU ...

Mechanism of Sarcopenia in Heart Failure

Aarhus University Hospital

Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF

The Cleveland Clinic

A Multi-center Cardiac PYP Scan Registry in Taiwan

Far Eastern Memorial Hospital

Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume

heaRtInsiGHT Alert guIDE: RightAIDE Application of the HeartInsight Acute Heart Failure Predictor in Routine Clinical Practice: Organizational Models and Workflow.

University of Padova

Optimization of Cardiac Resynchronization Therapy by Non-Invasive Imaging of Cardiac Electrophysiology

Medical University Innsbruck

Left Bundle Branch Area Pacing (LBBAP) PMCF Study

Brazil, France, Germ...

Abbott Medical Devices

SCAPIS 2 Cardio - Vibrometer Based Pulse Wave Analysis and CVD Risk Assessment

HJN Sverige AB/Neko Health

RAFT - Pace &Ablate

V-Lap System For Wirelessly Measuring And Monitoring Left Atrial Pressure (LAP) In Patients With Advance CHF

Vectorious Medical Technologie...

Lifestyle Behaviours of Women Newly Diagnosed With Heart Failure

Newcastle University

Heart Rate Regularization in Atrial Fibrilation and Heart Failure

Daniel Rodríguez Muñoz

A Pilot Randomized Controlled Trial Comparing Core Exercise, Aerobic Exercise, and Combined Exercise in Patients Undergoing Phase II Cardiac Rehabilitation.

National Taiwan University Hos...

Percutaneous Coronary RevascularizatiOn VERsus Coronary-Artery Bypass Grafting for Multivessel Disease in Patients With Left Ventricular Dysfunction (PROVERB)

Assistance Publique - Hôpitaux...

Project 4: ACHIEVE PATHFINDER

Henry Ford Health System

Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant

Hospital Clinic of Barcelona

Clinical Outcomes of Cardiovascular Disease

Xinjiang Medical University

HeartLogic™ in Patients With Heart Failure.

Poitiers University Hospital

NCT02966665 Phase 1

: Vascular Function in Health and Disease

NCT06424288 Phase 3

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

United States, Argen...

Boehringer Ingelheim

Rate or Rhythm Control in CRT: the RHYTHMIC Study

Guy's and St Thomas' NHS Found...

The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.

Jersey, United Kingd...

University of Oxford

Integrated Approach in Frail Older People with Atrial Fibrillation

Bulgaria, Denmark, I...

Heart Care Foundation

The Value of a Simple Tool for the Early Detection of Decompensated Heart Failure in People Over 55 on Réunion Island: A Preliminary Study in Hospitals (DEPIST'IC-RUN)

Centre Hospitalier Universitai...

Primary Preventive Ventricular Tachycardia Ablation In High-Risk Patients Who Receive A Prophylactic Implantable Cardioverter Defibrillator

Denmark, France, Spa...

University of Rochester

Evaluation of Heart Failure Telemonitoring Eligibility Criteria

University Hospital, Clermont-...

NCT06642272 Phase 4

A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record

Herlev and Gentofte Hospital

Molecular Underpinnings of Heart Failure, Integrative Multi-Omics, and Non-Coding RNA Profiling

University of Zurich

Registry of Pavia Chronic Heart Failure Patients-observational Study

Fondazione IRCCS Policlinico S...

NCT05718128 Phase 4

Clinical Study of Endocardial Myocardial Biopsy

Second Affiliated Hospital, Zh...

Acute Response to Left Bundle Branch Area Pacing With SyncAV

Abbott Medical Devices

Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure

Study to Collect High-Resolution ECG Data and Patient Insights on Heart Failure Care

Richmond Research Institute

NCT07631156 Phase 4

STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart Failure

iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic Diseases

Brazil, Chile, Costa...

Evaluation of the Effects of Sauna Therapy on Congestion and Loop Diuretic Use in Patients With Heart Failure With Reduced or Moderately Reduced Ejection Fraction

Central Hospital, Nancy, Franc...

Related Conditions

cardiomyopathies (4) cardiovascular diseases (4) heart failure with reduced ejection fraction (4) hypertension (4) atrial fibrillation (4) coronary artery disease (3) cardiogenic shock (3) mitral regurgitation (2) valvular heart disease (2) heart transplantation (2) ckd (2) heart failure nyha class ii (2)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology