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heart failure

Total Trials

83

Recruiting Now

83

Trial Phases

Phase 2, Phase 4, Phase 3

ClinicalMetric tracks all active clinical trials for heart failure sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — heart failure Clinical Trials

How many clinical trials are currently recruiting for heart failure?

ClinicalMetric currently tracks 83 actively recruiting clinical trials for heart failure, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 83. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for heart failure?

heart failure research spans Phase 1 (1 trial), Phase 2 (5 trials), Phase 3 (2 trials), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a heart failure clinical trial?

Eligibility criteria for heart failure trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

1

Phase 2

5

Phase 3

2

Phase 4

3

Top Sponsors

University of Texas Southwestern Medical Center 2 trials

The Cleveland Clinic 2 trials

Herlev and Gentofte Hospital 2 trials

Endotronix, Inc. 2 trials

Kafrelsheikh University 2 trials

Recruiting Clinical Trials

BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction

Use of ReDS Technology in Patients With Acute Heart Failure

Icahn School of Medicine at Mo...

NCT06979362 Phase 2

A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

United States, Canad...

Novo Nordisk A/S

Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)

University Medical Center Gron...

AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

Peerbridge Health, Inc

Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)

Weill Medical College of Corne...

Perioperative Interdisciplinary, Intersectoral Process Optimization in Heart Failure

University of Giessen

NCT06427343 Phase 4

The Effects of Low-Dose Versus High-Dose Intravenous IRON Therapy With Ferric DerisomaltOSE in Patients With Chronic Heart Failure and Iron Deficiency

China-Japan Friendship Hospita...

Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes

University of Texas Southweste...

NCT06080074 Phase 2

Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

Stanford University

Atrial Fibrillation Ablation Versus Atrioventricular Nodal Ablation with Conduction System Pacing in Heart Failure

Austria, Belgium, Bu...

University Hospital, Geneva

NCT05732051 Phase 2

Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients

University Hospital, Akershus

Development of CIRC Technologies

The Cleveland Clinic

The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) Registry: An Observational Study on Cardiac Rehabilitation in Patients With Coronary Disease or Heart Failure

Fondazione Don Carlo Gnocchi E...

NCT07234422 Phase 3

The SELEQT-HF (SELEnium and CoQ10 NuTrition for Heart Failure) Study Will Evaluate the Effect of Adding Selenium/and coQ10 on Top of Standard HF Therapy in Patients With HF and Will do so Using a Pragmatic, Registry Based Randomized Controlled Trial in the Netherlands.

Netherlands Heart Institute

NCT06642272 Phase 4

A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record

Herlev and Gentofte Hospital

Project 4: ACHIEVE PATHFINDER

Henry Ford Health System

Proof-of-concept of a Behavioral Intervention to Improve the Cardiovascular Health of People Living With HIV

United States, Brazi...

University of Washington

Sarcopenia in Older Patients Hospitalized for Acute Heart Failure.

Fundacion para la Investigacio...

PAtient Treatment Analysis: Hospital and Wide-ranging Out-of-hospital Care Assessment Yields Insights Into Heart Failure Outcomes

Pr. Nicolas GIRERD

Community Exercise Treating Effect on Cardiopulmonary Disease Patients

Guangdong Provincial People's ...

Expanded Studies on the SCAPIS Stockholm Reexamination Cohort

Danderyd Hospital

Evaluating the Safety and Effectiveness of 5G Cloud Follow-up for Cardiovascular Implantable Electronic Devices

The Third People's Hospital of...

Mobile Applet for Weight Management in Obese Heart Failure Patients

Heart Health Research Center

Multicenter Evaluation of Patients Using LATITUDE Monitoring System

University Hospital of Ferrara

Liberal or Restricted Fluid Intake in Patients With Heart Failure

Region Stockholm

A Prospective, Observational, Single Centre Study to Assess the Feasibility of the Data Harvested by the Acorai Intracardiac Pressure Monitoring (ICPM) System in Predicting Prognosis in Patients Discharged From Hospital After Treatment for Acute Decompensated Heart Failure

Royal Brompton & Harefield NHS...

SCAPIS 2 Cardio - Vibrometer Based Pulse Wave Analysis and CVD Risk Assessment

HJN Sverige AB/Neko Health

Investigation of the Effect of Inspiratory Muscle Training and Dual-Task Inspiratory Muscle Training on Cognitive Functions in Heart Failure

Turkey (Türkiye)

Istanbul University - Cerrahpa...

Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence

ROM Technologies, INC

The HEARTFELT Study

Heartfelt Technologies

Hybrid Ablation of Atrial Fibrillation in Heart Failure

St. George's Hospital, London

Improving Self-Care of Caregivers of Adults in Homecare With Heart Failure and Cognitive Impairment

Visiting Nurse Service of New ...

BiVACOR® Total Artificial Heart Early Feasibility Study

The DAPA-MEMRI Trial

University of Edinburgh

Eccentric Resistance Training Among Individuals With Chronic Heart Failure

Riphah International Universit...

NCT06008197 Phase 3

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

United States, Argen...

Colorado Prevention Center

Care Coordination to Assess Improvement in Outcomes in Hospital Readmissions

Reforça't: A Community, Social, and Healthcare Program for Patients With Cardiorespiratory Conditions Upon Hospital Discharge

Corporació de Salut del Maresm...

NCT07551167 Phase 1

A Clinical Study of HRS-5765 in Healthy Participants

Chengdu Suncadia Medicine Co.,...

Heart Rate Regularization in Atrial Fibrilation and Heart Failure

Daniel Rodríguez Muñoz

Acute Response to Left Bundle Branch Area Pacing With SyncAV

Abbott Medical Devices

Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure

Endotronix, Inc.

Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis

Mitochondrial Substrate Utilization in the Diabetic Human Heart

Heinrich-Heine University, Due...

V-Lap System For Wirelessly Measuring And Monitoring Left Atrial Pressure (LAP) In Patients With Advance Chronic Heart Failure

Vectorious Medical Technologie...

CCM OPEN HF Registry

Impulse Dynamics

XVIVO Heart Transplant Study in Clinical Practice

XVIVO Perfusion

Home-based Cardiac Rehabilitation for People Living With Heart Failure and Their Caregivers- The DK:REACH-HF Pilot Study

Herlev and Gentofte Hospital

AI-based Prediction of Cardiac Function Using Echocardiography and Body Composition Data (ECHO-FIT Study)

Yonsei University

SOCIAL_HF: Improving Social Frailty Through Interactive Learning

The University of Hong Kong

CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

VA Office of Research and Deve...

Predicting Readmissions Using Omics, Biostatistical Evaluate and Artificial Intelligence

Institute for Clinical Evaluat...

Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement

Oregon Health and Science Univ...

NCT06645691 Phase 2

Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body

National Heart Centre Singapor...

MIRAMACS, Multicenter Italian Study on RAdial Mechanically Assisted Circulatory Support

IRCCS Azienda Ospedaliero-Univ...

The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.

Jersey, United Kingd...

University of Oxford

Heart Failure Management for Patient With CIED Remotely Monitored

Drug Management in Heart Failure

IRCCS San Raffaele Roma

Preventive Catheter Ablation for Ventricular arrhythmiaS in Patients With End-sTage Heart faiLure

Heart and Diabetes Center Nort...

Effect of Sodium Glucose Co-tansporter 2 Inhibitors (SGLT2I) on Inflammatory and Oxidative Stress Markers Level in Heart Failure Patients

Kafrelsheikh University

A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

United States, Belgi...

Endotronix, Inc.

HeartLogic™ in Patients With Heart Failure.

Poitiers University Hospital

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

Northwestern University

Sacubitril/Valsartan in Patients With Prosthetic Heart Valves With Heart Failure and Reduced Ejection Fraction

Kafrelsheikh University

Prognostic Value of BNP in MCS - a 25 Year Follow up Study

Rigshospitalet, Denmark

Use of Artificial Intelligence-Guided Echocardiography to assIst cardiovascuLar Patient managEment

Baker Heart and Diabetes Insti...

European Registry of Transcatheter Repair for Tricuspid Regurgitation

Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure

Mid and South Essex NHS Founda...

Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues

Arunark Kolipaka

Uppsala Self-SCREENing of Heart Failure Study

Uppsala University

Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

Johns Hopkins University

BIO|STREAM.CSP Study

Australia, Austria, ...

Biotronik SE & Co. KG

Cardiogenic Shock Integrated PHenotyping for Event Reduction

Niguarda Hospital

IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION

Johann Wolfgang Goethe Univers...

Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II

United States, Unite...

Cardiac Contractility Modulation in Chagas Heart Disease

InCor Heart Institute

Wearable Technology in Heart Failure Patients

The Cleveland Clinic

NCT04654988 Phase 4

Study to Evaluate the Efficacy of Immunosuppression in Myocarditis or Inflammatory Cardiomyopathy.

Medical University of Warsaw

Heart Failure Virtual Ward Research Study

National University of Ireland...

Assessing Systemic Circulation and LV Performance in Adults

University of Calgary

NCT06130059 Phase 2

Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation

University of Texas Southweste...

Related Conditions

cardiovascular diseases (4) valvular heart disease (3) myocardial infarction (3) atrial fibrillation (3) heart failure nyha class iii (3) coronary artery disease (2) ischemic heart disease (2) cardiotoxicity (2) congenital heart disease (2) atrial fibrillation persistent (2) cardiac rehabilitation (2) heart failure with reduced ejection fraction (2)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology