Medical Condition

heart failure

Total Trials

75

Recruiting Now

75

Trial Phases

Phase 3, Phase 1, Phase 2, Phase 2

ClinicalMetric tracks all active clinical trials for heart failure sourced from ClinicalTrials.gov. Each listing includes the NCT identifier, current recruitment status, phase, primary endpoints, sponsor, estimated enrollment, and participating countries — updated daily as new studies open and status changes.

Recruiting trials currently enrolling participants, with eligibility criteria and age requirements
Phase 1–4 studies from early safety trials to post-marketing surveillance
NIH, pharmaceutical sponsor, and academic medical center studies worldwide
AI-powered plain-language summary available for every trial listing

Frequently Asked Questions — heart failure Clinical Trials

How many clinical trials are currently recruiting for heart failure?

ClinicalMetric currently tracks 75 actively recruiting clinical trials for heart failure, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 75. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for heart failure?

heart failure research spans Phase 1 (3 trials), Phase 2 (6 trials), Phase 3 (2 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a heart failure clinical trial?

Eligibility criteria for heart failure trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 3

Phase 4

Top Sponsors

Charite University, Berlin, Germany 2 trials

Ruijin Hospital 2 trials

Tufts Medical Center 2 trials

University of Rochester 2 trials

Herlev and Gentofte Hospital 2 trials

heart failure

Frequently Asked Questions — heart failure Clinical Trials

Recruiting Clinical Trials

Mechanisms And Prognosis of Stroke-Heart Syndrome

Selenium Intervention Registry Randomized Trial in Heart Failure

Screen CardRen - A Cross-sectional Observational Cohort Study

The HEARTFELT Study

Heart Failure and Aortic Stenosis Transcriptome

POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium

Cardiometabolic evalUation REgistry of Heart Failure

Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure

Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure

Magenta Elevate™ Clinical Feasibility Study in Cardiogenic Shock

Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List

BiVACOR® Total Artificial Heart Early Feasibility Study

Seasonal Physical Activity in Patients With Heart Failure With Cardiac Implantable Electronic Devices

Heart Failure Virtual Ward Research Study

Primary Preventive Ventricular Tachycardia Ablation In High-Risk Patients Who Receive A Prophylactic Implantable Cardioverter Defibrillator

Percutaneously Delivered Automated Continual Fluid Removal System in Patients With Advanced Diuretic-Resistant Heart Failure

Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF

Empagliflozin in ESKD - A Feasibility Study

Pulmonary Artery Catheter in Cardiogenic Shock Trial

Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS)

COLchicine and Thiamine in Heart Failure Due to Ischemic Heart Disease

Research on Optimal Diagnosis and Treatment of Cardiorenal Syndrome

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation

Drug Management in Heart Failure

PRagmatic Trial Of Messaging to Providers About Treatment of Heart Failure at Inova

Registry for Longitudinal Mortality and Therapy in Patients With Heart Failure

Prognostic Value of BNP in MCS - a 25 Year Follow up Study

V-Lap System For Wirelessly Measuring And Monitoring Left Atrial Pressure (LAP) In Patients With Advance Chronic Heart Failure

Factors Influencing Participation in PRADO and Telemedicine Interventions in Heart Failure

Community Exercise Treating Effect on Cardiopulmonary Disease Patients

HIV-HEART Aging Study

Integrated Approach in Frail Older People with Atrial Fibrillation

Pharmacokinetic and Pharmacodynamic of Jia Shen Tablets in Chronic Heart Failure

Use of ReDS Technology in Patients With Acute Heart Failure

The Effects of Low-Dose Versus High-Dose Intravenous IRON Therapy With Ferric DerisomaltOSE in Patients With Chronic Heart Failure and Iron Deficiency

The Multicenter Cardiology Monitoring Platform Registry

Clinical Study of Impact of Different Pacing Site in Patients

Elastic Band-Progressive Resistance Training (EB-PRT) for Sarcopenia Among Heart Failure Patients

China Extracorporeal Life Support Registry

Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure

VIrtual Care To Improve Outcomes and RecoverY From Heart Failure Hospitalization

iP2P Mentorship Program for Adolescent HF Patients

IRONHEART: Intravenous Iron in Non-ischaemic Heart Failure

Implantable Cardioverter Defibrillator (ICD Registry)

Investigating Myocardial Remodelling in the Failing Human Heart

LVAD Conditioning for Cardiac Recovery

Baduanjin-eight-silken-movement With Self-efficacy Building for Patients With Chronic Heart Failure (BESMILE-HF Study)

Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation

iPSC Biobank of Biomarkers Diversity in Cardiovascular Disease

Quantifying New Heart Muscle Cells

A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure

Effects of Negative Pressure Ventilation Onto Hemodynamics and Right Ventricular Funktion in Patients After Implantation of a Left Ventricular Assist Device.

Effects of Early Cardiopulmonary Rehabilitation in Patients With Acute Decompensated Heart Failure

Metabolic Abnormalities, Lifestyle and Diet Pattern in Heart Failure

Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan

A Feasibility Study Implant of the WiSE® CRT System With an Intracardiac Pacemaker to Achieve Totally Leadless CRT

INTEgRated Health CARE for Patients With Frailty and Heart Failure

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

SGLT2 for Heart Failure in CHD Patients

Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body

Sacubitril/Valsartan in Patients With Prosthetic Heart Valves With Heart Failure and Reduced Ejection Fraction

Evaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.

Intensive Care Unit-acquired Heart Failure in Critically Ill: the ICU-HF Study

Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis

Study to Collect High-Resolution ECG Data and Patient Insights on Heart Failure Care

Feasibility Study of Diaphragm Synchronized Pacing (DSP) Via the Left Inferior Phrenic Vein (LIPV) Approach

Validation of the Prognostic Impact of a Retinal Photograph-based Cardiovascular Disease Risk Stratification System in de Novo HFrEF

His-Bundle Corrective Pacing in Heart Failure

Perioperative Interdisciplinary, Intersectoral Process Optimization in Heart Failure

Home-based Cardiac Rehabilitation for People Living With Heart Failure and Their Caregivers- The DK:REACH-HF Pilot Study

The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)

Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients