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heart failure

Total Trials

90

Recruiting Now

90

Trial Phases

Phase 4, Phase 3, Phase 1

ClinicalMetric tracks all active clinical trials for heart failure sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — heart failure Clinical Trials

How many clinical trials are currently recruiting for heart failure?

ClinicalMetric currently tracks 90 actively recruiting clinical trials for heart failure, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 90. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for heart failure?

heart failure research spans Phase 1 (2 trials), Phase 2 (6 trials), Phase 3 (8 trials), Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a heart failure clinical trial?

Eligibility criteria for heart failure trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

2

Phase 2

6

Phase 3

8

Phase 4

2

Top Sponsors

University of Texas Southwestern Medical Center 3 trials

Colorado Prevention Center 2 trials

Jiangsu Taizhou People's Hospital 2 trials

University of Illinois at Chicago 2 trials

Lakeland Regional Health Systems, Inc. 1 trial

Recruiting Clinical Trials

NCT07263035 Phase 4

Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure

Lakeland Regional Health Syste...

Cardiac RadiothErapy For hEart faiLure

Universitaire Ziekenhuizen KU ...

NCT06008197 Phase 3

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

United States, Argen...

Colorado Prevention Center

Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy

Ashkan Eftekhari

CardioMEMS HF System Coverage With Evidence Development Study

Abbott Medical Devices

NCT02966665 Phase 1

: Vascular Function in Health and Disease

Russell Richardson

A Prospective, Observational, Single Centre Study to Assess the Feasibility of the Data Harvested by the Acorai Intracardiac Pressure Monitoring (ICPM) System in Predicting Prognosis in Patients Discharged From Hospital After Treatment for Acute Decompensated Heart Failure

Royal Brompton & Harefield NHS...

RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure

University Hospital Southampto...

Digital Health Physical Activity Program for Older Family Care Partners of Patents With Heart Failure

University of Colorado, Denver

Construction of a Cohort of Elderly Patients With Atrial Fibrillation in Rural China

Jiangsu Taizhou People's Hospi...

NCT06033950 Phase 3

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients with Heart Failure Who Are Intolerant or Not Eligible for Treatment with Steroidal Mineralocorticoid Receptor Antagonists

United States, Brazi...

Colorado Prevention Center

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

United States, Austr...

Retrospective Prospective Multicentric Clinical Follow up of Patients After Being Treated With TricValve®

Austria, Belgium, Ge...

P+F Products + Features GmbH

The Role of Cardiac Mechanics, Biomarkers and Frailty in Aortic Stenosis

Christine Henri

Inspiratory Muscle Training in Hospitalized Heart Failure Patients

CAROLINA NIGRO DI LEONE

AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

Peerbridge Health, Inc

Determining Efficacy of an Artificial Intelligence-based System for Heart Failure Detection Through Interpretation of Electrocardiograms (DECISION)

Idoven 1903 S.L.

NCT06200207 Phase 3

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

United States, Argen...

Novo Nordisk A/S

The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry)

EBR Systems, Inc.

Cohort Study of Chronic Heart Failure

Jiangsu Taizhou People's Hospi...

IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION

Johann Wolfgang Goethe Univers...

Registry for Longitudinal Mortality and Therapy in Patients With Heart Failure

Shanghai 10th People's Hospita...

Study of the Progression of Chronic Cardiovascular Conditions

Hybrid Ablation of Atrial Fibrillation in Heart Failure

St. George's Hospital, London

Project 4: ACHIEVE PATHFINDER

Henry Ford Health System

NCT05194111 Phase 1, Phase 2

Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan

Virginia Commonwealth Universi...

Research on Optimal Diagnosis and Treatment of Cardiorenal Syndrome

Nanjing First Hospital, Nanjin...

Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation

Georgia, Italy, Lith...

Development of CIRC Technologies

The Cleveland Clinic

NCT06677060 Phase 3

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

United States, Argen...

Intensive Prevention Program After Decompensated Heart Failure

Herzzentrum Bremen

Impella Pump Return Study to Analyze Deposits and Biomaterial in Used Pumps

Danish Evaluation of Early Catheter Ablation for Atrial Fibrillation in Patients With Heart Failure

Aalborg University Hospital

BRING-UP 3 Heart Failure

Heart Care Foundation

A Randomized Controlled Trial of LOT-CRT Versus conventionaL BiVP in Heart Failure Patients With NICD

The First Affiliated Hospital ...

Impact of Optimized Pacing Strategies on Clinical and Hemodynamic Outcomes in Heart Failure Patients With Pacemaker

Samsung Medical Center

Effects of Negative Pressure Ventilation Onto Hemodynamics and Right Ventricular Funktion in Patients After Implantation of a Left Ventricular Assist Device.

Karlsburg Hospital

Feasibility Study of Diaphragm Synchronized Pacing (DSP) Via the Left Inferior Phrenic Vein (LIPV) Approach

UIC Multi-Ethnic DCM Registry

University of Illinois at Chic...

Timing of Coronary Angiography in NSTEMI Complicated by Acute HF

Chonnam National University Ho...

TEXT4HF: A Randomized Controlled Trial of a Tailored Text Messaging Intervention to Improve Self-Care in Older Adult Patients With Heart Failure

University of Illinois at Chic...

Elastic Band-Progressive Resistance Training (EB-PRT) for Sarcopenia Among Heart Failure Patients

The University of Hong Kong

The Role of CD34+ Stem Cells in the Pathogenesis of Takotsubo Syndrome

University Medical Centre Ljub...

NCT05465031 Phase 4

Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)

Silesian Centre for Heart Dise...

Effect of Resistance Training in Patients on the Waiting List for Heart Transplant

University of Sao Paulo Genera...

Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery

Hochgebirgsklinik Davos

MIRAMACS, Multicenter Italian Study on RAdial Mechanically Assisted Circulatory Support

IRCCS Azienda Ospedaliero-Univ...

IEEM-Heat and Heart Failure

University of Texas Southweste...

Microbiota-Inflammation-Brain Axis in Heart Failure: New Functional Food for the Prevention of undeRnutrition in Older

Azienda Ospedaliero-Universita...

NCT06349941 Phase 3

Home-based Cardiac Rehabilitation in Heart Failure

University of Texas Southweste...

Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)

University Medical Center Gron...

Use of Point-of-Care Ultrasound (POCUS) to Reduce Hospital Length of Stay in Patients With Heart Failure ( POCUSHF )

Florida International Universi...

Multidisciplinary Approach for High Risk Patients Leading to Early Diagnosis of Canadians in Heart Failure

Cardiology Research UBC

NCT03383419 Phase 2

Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients

Baylor Research Institute

Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

Brigham and Women's Hospital

NCT06694727 Phase 3

A Danish Pragmatic Randomized Trial of Nutritional Supplements in Heart Failure

Tor Biering-Sørensen

Gender Specific Registry in Subjects Hospitalized With Heart Failure in Santiago

Fundacion de la Sociedad Chile...

NCT05714085 Phase 2, Phase 3

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

United States, Belgi...

Merck Sharp & Dohme LLC

High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2)

Medical University Innsbruck

Quantifying New Heart Muscle Cells

Weill Medical College of Corne...

Bolt CSP-M Holter Study

Medtronic Cardiac Rhythm and H...

The Türkiye Heart Failure Registry

Turkey (Türkiye)

Baskent University

Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure

Mid and South Essex NHS Founda...

High Intensity His Bundle Pacing in Heart Failure Patients With Narrow QRS Outcome Study

Miulli General Hospital

Non-invasive Filling Pressure(NIFP) Device Based on Low Frequency Heart Sound in Assessment of Congestion in Heart Failure Patients

The University of Hong Kong-Sh...

NCT05562167 Phase 2

The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)

Washington University School o...

STICH-3.0 International Trial Consortium

Vastra Gotaland Region

Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes

University of Texas Southweste...

Aeson TAH System - Post-Market Clinical Follow-up Study

AMBulatory UltraSound for Heart Failure Management

Central Hospital, Nancy, Franc...

Cardiogenic Shock Integrated PHenotyping for Event Reduction

Niguarda Hospital

Genetic and Immunity in Heart Failure

Fondazione Policlinico Univers...

NCT04982419 Phase 2, Phase 3

Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

VA Office of Research and Deve...

Studies of Neuregulin/ERBB Signaling in Human Heart

Douglas B. Sawyer

Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF

Future University in Egypt

Clonal Hematopoiesis of Indeterminate Potential in Heart Failure.

FROM- Fondazione per la Ricerc...

The Effect of a Smartphone-assisted Hybrid Cardiac Rehabilitation Program in Patients With Heart Failure.

National Taiwan University Hos...

Cardiac Magnetic Resonance-Clinical Prediction Model-Dilated Cardiomyopathy

Shandong Provincial Hospital

Home-based Outpatient Multicenter Evaluation Using Electrocardiogram (HOME-ECG)

National Defense Medical Cente...

The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.

Jersey, United Kingd...

University of Oxford

BIO-2-HEART: Identification of Biomarkers in T2DM and Heart Failure

RWTH Aachen University

VIrtual Care To Improve Outcomes and RecoverY From Heart Failure Hospitalization

Canada, Tunisia

Population Health Research Ins...

Precision Rehabilitation for Veterans With (HFpEF)

Columbia VA Health Care System

Heart Failure and Aortic Stenosis Transcriptome

IRCCS Policlinico S. Donato

Implantable Cardioverter Defibrillator (ICD Registry)

American College of Cardiology

Cardiology Research Dubrava Prospective Registry

University Hospital Dubrava

Care Coordination to Assess Improvement in Outcomes in Hospital Readmissions

Using a Connected Application to Maintain Physical Activity After Cardiac Rehabilitation

University Hospital, Angers

Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging

Fatebenefratelli Hospital

NCT03629340 Phase 2

Metformin for Pulmonary Hypertension HFpEF

University of California, San ...

Related Conditions

atrial fibrillation (5) aortic stenosis (4) dilated cardiomyopathy (3) decompensated heart failure (3) bradycardia (3) valvular heart disease (3) coronary artery disease (3) non ischemic cardiomyopathy (2) ischemic cardiomyopathy (2) hypertension (2) atrial fibrillation af (2) arrhythmia (2)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology