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small lymphocytic lymphoma

Total Trials
6
Recruiting Now
6
Trial Phases
Phase 2, Phase 1, Phase 2

Lymphoma trials span diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, Hodgkin lymphoma, mantle cell lymphoma, and T-cell lymphomas β€” each with distinct biology and treatment response. CAR-T cell therapy has established a new standard in relapsed/refractory DLBCL, and trials now aim to move this approach earlier in the treatment sequence.

Active trials evaluate bispecific antibodies (mosunetuzumab, epcoritamab, glofitamab), next-generation CAR-T cell products (CD19/CD22 dual targets, BCMA-targeting), BTK inhibitors in B-cell lymphomas, and total metabolic volume on PET as a predictive biomarker for treatment adaptation.

Frequently Asked Questions — small lymphocytic lymphoma Clinical Trials

How many clinical trials are currently recruiting for small lymphocytic lymphoma?
ClinicalMetric currently tracks 6 actively recruiting clinical trials for small lymphocytic lymphoma, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 6. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for small lymphocytic lymphoma?
small lymphocytic lymphoma research spans Phase 1 (1 trial), Phase 2 (6 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a small lymphocytic lymphoma clinical trial?
Eligibility criteria for small lymphocytic lymphoma trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
1
Phase 2
6
Top Sponsors
Masonic Cancer Center, University of Minnesota 1 trial
Zulfa Omer 1 trial
BeOne Medicines 1 trial
Kerry Rogers 1 trial
University of Utah 1 trial

Recruiting Clinical Trials

NCT05805605 Phase 2
Recruiting
Allo HSCT Using RIC and PTCy for Hematological Diseases
Enrollment
56 pts
Location
United States
Sponsor
Masonic Cancer Center, Univers...
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NCT06978088 Phase 2
Recruiting
LP-168 and Obinutuzumab for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Variants of This
Enrollment
34 pts
Location
United States
Sponsor
Zulfa Omer
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NCT05006716 Phase 1, Phase 2
Recruiting
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
Enrollment
645 pts
Location
United States, Austr...
Sponsor
BeOne Medicines
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NCT06466122 Phase 2
Recruiting
Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi
Enrollment
30 pts
Location
United States
Sponsor
Kerry Rogers
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NCT05183854 Phase 2
Recruiting
Pneumococcal Pneumonia Vaccine Series (PCV20 and PPSV23) in Patients With Chronic Lymphocytic Leukemia Associated Immunodeficiency, PROTECT CLL Trial
Enrollment
61 pts
Location
United States
Sponsor
University of Utah
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NCT05694312 Phase 2
Recruiting
Ibrutinib for the Treatment of AIHA in Patients With CLL/SLL or CLL-like MBL
Enrollment
45 pts
Location
Italy
Sponsor
Gruppo Italiano Malattie EMato...
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Related Conditions

chronic lymphocytic leukemia (5) marginal zone lymphoma (2) follicular lymphoma (2) acute myelogenous leukemia (1) acute lymphocytic leukemia (1) biphenotypic acute leukemia (1) undifferentiated leukemia (1) prolymphocytic leukemia (1) chronic myelogenous leukemia (1) plasma cell leukemia (1) myelodysplastic syndromes (1) leukemia myeloid (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: September 2026  ·  Data Methodology