State NC
Clinical Trials in North Carolina
North Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in North Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 385 actively recruiting studies with North Carolina sites out of 385 registered in total. The busiest research areas in North Carolina are Breast Cancer, Ovarian Cancer, Systemic Lupus Erythematosus. Leading sponsors running trials in the state include Wake Forest University Health Sciences, Duke University, National Cancer Institute (NCI). By stage, North Carolina trials break down as Phase 1 (52), Phase 2 (90), Phase 3 (101), Phase 4 (15).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in North Carolina
Frequently Asked Questions — Clinical Trials in North Carolina
How many clinical trials are currently recruiting in North Carolina?
ClinicalMetric currently tracks 385 actively recruiting clinical trials with at least one location in North Carolina. The total number of registered studies—including active but not currently enrolling trials—is 385. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in North Carolina?
North Carolina hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Ovarian Cancer, Systemic Lupus Erythematosus, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout North Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in North Carolina?
To join a clinical trial in North Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in North Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in North Carolina
NCT06995898 N/A
Recruiting
The Vanguard Study: Testing a New Way to Screen for Cancer
Condition
Bladder Carcinoma
Enrollment
24,000 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT07493265 Phase 2
Recruiting
A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy
Condition
Narcolepsy
Enrollment
64 pts
Location
United States, Belgium, Canada
Sponsor
Eisai Inc.
NCT05946044 N/A
Recruiting
The Osteoarthritis Prevention Study
Condition
Osteoarthritis, Knee
Enrollment
1,230 pts
Location
United States, Australia
Sponsor
Wake Forest University
NCT04671667 Phase 2
Recruiting
Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itse...
Condition
Recurrent Head and Neck Squamous Cell Carcinoma
Enrollment
188 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT07339111 Phase 3
Recruiting
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cart...
Condition
Knee Cartilage Defects
Enrollment
300 pts
Location
United States
Sponsor
Medipost, Inc.
NCT06616194 Phase 3
Recruiting
A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With ...
Condition
Migraine
Enrollment
200 pts
Location
United States, Canada, China
Sponsor
Pfizer
NCT07415954 Phase 2
Recruiting
A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419...
Condition
Diabetes Mellitus, Type 2
Enrollment
270 pts
Location
United States, Croatia, Hungary
Sponsor
Novo Nordisk A/S
NCT06563895 Phase 3
Recruiting
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) S...
Condition
Amyloidosis
Enrollment
587 pts
Location
United States, Argentina, Australia
Sponsor
Eidos Therapeutics, a BridgeBi
NCT06872905 N/A
Recruiting
Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endopros...
Condition
Aortoiliac Occlusive Disease
Enrollment
158 pts
Location
United States, Italy, Netherlands
Sponsor
W.L.Gore & Associates
NCT06696001 N/A
Recruiting
Neuroscience of Psychotherapy for Depression
Condition
Depression
Enrollment
45 pts
Location
United States
Sponsor
University of North Carolina,
NCT04107181 N/A
Recruiting
Pilot Study for Speculum Free Cervical Cancer Screening
Condition
Cervical Cancer
Enrollment
305 pts
Location
United States
Sponsor
Duke University
NCT07086781 N/A
Recruiting
Resources for Optimizing Outcomes in Toddlers on the Spectrum
Condition
Autism Spectrum Disorder
Enrollment
60 pts
Location
United States
Sponsor
University of North Carolina,
NCT06895070 N/A
Recruiting
XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Ac...
Condition
Heart Transplant
Enrollment
60 pts
Location
United States
Sponsor
XVIVO Perfusion
NCT07309445 N/A
Recruiting
A Study to Assess Real-World Use and Outcomes of TAR-200 for Participants With N...
Condition
Non-Muscle Invasive Bladder Neoplasms
Enrollment
150 pts
Location
United States
Sponsor
Janssen Research & Development
NCT05763251 N/A
Recruiting
Comparison of Uncomplicated Candidemia Therapy Duration in Children
Condition
Invasive Candidiasis
Enrollment
420 pts
Location
United States, Australia
Sponsor
Arkansas Children's Hospital R
NCT07391657 Phase 3
Recruiting
A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antig...
Condition
Relapsed Refractory Multiple Myeloma
Enrollment
508 pts
Location
United States, Australia, Brazil
Sponsor
AstraZeneca
NCT05149573 N/A
Recruiting
Investigation of PEMF Therapy for Female Patients With IC/BPS
Condition
Interstitial Cystitis
Enrollment
75 pts
Location
United States
Sponsor
Wake Forest University Health
NCT06588556 N/A
Recruiting
Improving Needs Among Older Adults
Condition
Critical Illness
Enrollment
350 pts
Location
United States
Sponsor
Duke University
NCT06911424 Phase 3
Recruiting
Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis
Condition
Bacterial Conjunctivitis
Enrollment
400 pts
Location
United States
Sponsor
Baxis Pharmaceuticals, Inc.
NCT04900818 Phase 1
Recruiting
Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tum...
Condition
Solid Tumor
Enrollment
330 pts
Location
United States, China
Sponsor
I-Mab Biopharma US Limited
NCT06619990 Phase 1, Phase 2
Recruiting
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Coliti...
Condition
Ulcerative Colitis (UC)
Enrollment
270 pts
Location
United States, Australia, Bulgaria
Sponsor
Xencor, Inc.
NCT04986423 Phase 2
Recruiting
ZEN003694 and Enzalutamide Versus Enzalutamide Monotherapy in Metastatic Castrat...
Condition
Metastatic Castration-Resistant Prostate Cancer
Enrollment
200 pts
Location
United States, China
Sponsor
Zenith Epigenetics
NCT07409103 Phase 2
Recruiting
A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat ...
Condition
Active Rheumatoid Arthritis
Enrollment
180 pts
Location
United States, South Africa
Sponsor
Elevara Medicines Limited
NCT07361341 N/A
Recruiting
Culturally Tailored Program for Food-Insecure Adults: SPICE-D
Condition
Type 2 Diabetes Mellitus (T2D)
Enrollment
25 pts
Location
United States
Sponsor
Wake Forest University Health
NCT06590454 Phase 2
Recruiting
REVerse Intestinal Metaplasia in the Stomach (REVISE)
Condition
Gastric Intestinal Metaplasia
Enrollment
32 pts
Location
United States
Sponsor
Katherine Garman
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology