State MA
Clinical Trials in Massachusetts
Massachusetts is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Massachusetts and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 474 actively recruiting studies with Massachusetts sites out of 474 registered in total. The busiest research areas in Massachusetts are Prostate Cancer, Colorectal Cancer, Breast Cancer. Leading sponsors running trials in the state include Massachusetts General Hospital, Brigham and Women's Hospital, Boston Children's Hospital. By stage, Massachusetts trials break down as Phase 1 (86), Phase 2 (125), Phase 3 (78), Phase 4 (14).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Massachusetts
Frequently Asked Questions — Clinical Trials in Massachusetts
How many clinical trials are currently recruiting in Massachusetts?
ClinicalMetric currently tracks 474 actively recruiting clinical trials with at least one location in Massachusetts. The total number of registered studies—including active but not currently enrolling trials—is 474. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Massachusetts?
Massachusetts hosts clinical trials across a broad range of medical conditions, including Prostate Cancer, Colorectal Cancer, Breast Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Massachusetts serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Massachusetts?
To join a clinical trial in Massachusetts, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Massachusetts maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Massachusetts
NCT04398628 N/A
Recruiting
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
Condition
Hematologic Disorder
Enrollment
3,000 pts
Location
United States
Sponsor
American Thrombosis and Hemost
NCT05358834 N/A
Recruiting
Testing Effects of Melatonin on Uterine Contractions in Women
Condition
Pregnant Women
Enrollment
120 pts
Location
United States
Sponsor
Brigham and Women's Hospital
NCT06303505 Phase 1, Phase 2
Recruiting
FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Pa...
Condition
Ovarian Cancer
Enrollment
334 pts
Location
United States, Belgium, Germany
Sponsor
Gilead Sciences
NCT06585605 N/A
Recruiting
A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Ph...
Condition
Epilepsy in Children
Enrollment
500 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT07186101 Phase 2
Recruiting
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately ...
Condition
Ulcerative Colitis
Enrollment
252 pts
Location
United States, Austria, Brazil
Sponsor
Eli Lilly and Company
NCT05729607 N/A
Recruiting
Vertical Soft Tissue Augmentation With CTG vs ADM
Condition
Implant Complication
Enrollment
28 pts
Location
United States
Sponsor
Harvard Medical School (HMS an
NCT06822439 N/A
Recruiting
Remote Fetal Monitoring in High Risk Pregnancies
Condition
High Risk Pregnancy
Enrollment
50 pts
Location
United States
Sponsor
Beth Israel Deaconess Medical
NCT07007312 Phase 3
Recruiting
Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With...
Condition
Acute Myeloid Leukemia (AML)
Enrollment
1,300 pts
Location
United States, Australia, Belgium
Sponsor
Kura Oncology, Inc.
NCT07085767 Phase 3
Recruiting
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/...
Condition
Breast Cancer
Enrollment
1,000 pts
Location
United States, Australia, Austria
Sponsor
Olema Pharmaceuticals, Inc.
NCT07128303 Phase 1
Recruiting
Study of GS-5319 Given Alone or in Combination in Adults With Solid Tumors
Condition
Advanced Solid Tumor
Enrollment
476 pts
Location
United States, South Korea, Spain
Sponsor
Gilead Sciences
NCT07222215 Phase 2
Recruiting
PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast ...
Condition
Estrogen-receptor-positive Breast Cancer
Enrollment
297 pts
Location
United States
Sponsor
Kristina A. Fanucci
NCT04206215 N/A
Recruiting
Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome
Condition
Chronic Pain
Enrollment
95 pts
Location
United States
Sponsor
Spaulding Rehabilitation Hospi
NCT07032818 N/A
Recruiting
Adapted Hospital Discharge Intervention: the CONNECT Pilot
Condition
Communication Research
Enrollment
60 pts
Location
United States
Sponsor
Boston Medical Center
NCT05882058 Phase 2
Recruiting
DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With...
Condition
Small Cell Lung Carcinoma
Enrollment
204 pts
Location
United States, Belgium, Bulgaria
Sponsor
Boehringer Ingelheim
NCT07016555 EARLY_Phase 1
Recruiting
Burning Mouth Syndrome: Symptoms and Management
Condition
Burning Mouth Syndrome
Enrollment
50 pts
Location
United States
Sponsor
University of Massachusetts, A
NCT04434040 Phase 2
Recruiting
Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)
Condition
Breast Cancer
Enrollment
40 pts
Location
United States
Sponsor
Dana-Farber Cancer Institute
NCT07485491 N/A
Recruiting
Enhancing Cardiac Rehabilitation Attendance After Secondary Myocardial Infarctio...
Condition
Type 2 Myocardial Infarction
Enrollment
60 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT07573176 Phase 3
Recruiting
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Ma...
Condition
Depressive Disorder, Major
Enrollment
600 pts
Location
United States, Argentina, Brazil
Sponsor
Janssen Research & Development
NCT06936878 N/A
Recruiting
BOLSTER: Learning New Skills to Thrive
Condition
Gastrointestinal Cancer
Enrollment
600 pts
Location
United States
Sponsor
Dana-Farber Cancer Institute
NCT05317585 N/A
Recruiting
Continuous Glucose Monitor Use in Pregnancy
Condition
Type 2 Diabetes Treated With Insulin
Enrollment
180 pts
Location
United States
Sponsor
University of Massachusetts, W
NCT07358078 N/A
Recruiting
DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients ...
Condition
Transthyretin Amyloidosis With Cardiomyopathy
Enrollment
2,000 pts
Location
United States, Germany, Japan
Sponsor
Alnylam Pharmaceuticals
NCT07101640 Phase 1, Phase 2
Recruiting
PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infan...
Condition
Bronchopulmonary Dysplasia (BPD)
Enrollment
28 pts
Location
United States
Sponsor
Duke University
NCT07326722 N/A
Recruiting
Delivering tAN to Reduce HMB: The LUNA Study
Condition
Heavy Menstrual Bleeding
Enrollment
80 pts
Location
United States
Sponsor
Spark Biomedical, Inc.
NCT05625659 N/A
Recruiting
Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breas...
Condition
Breast Cancer
Enrollment
2,032 pts
Location
United States, Canada
Sponsor
American College of Radiology
NCT07759154 Phase 3
Recruiting
A Study to Test the Effects of Centanafadine in Adults With Attention-deficit/Hy...
Condition
Attention-deficit/Hyperactivity Disorder
Enrollment
80 pts
Location
United States
Sponsor
Otsuka Pharmaceutical Developm
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology