Medical Condition

major depressive disorder

Total Trials

29

Recruiting Now

29

Trial Phases

Phase 4, Phase 3, Phase 2

ClinicalMetric tracks all active clinical trials for major depressive disorder sourced from ClinicalTrials.gov. Each listing includes the NCT identifier, current recruitment status, phase, primary endpoints, sponsor, estimated enrollment, and participating countries — updated daily as new studies open and status changes.

Recruiting trials currently enrolling participants, with eligibility criteria and age requirements
Phase 1–4 studies from early safety trials to post-marketing surveillance
NIH, pharmaceutical sponsor, and academic medical center studies worldwide
AI-powered plain-language summary available for every trial listing

Frequently Asked Questions — major depressive disorder Clinical Trials

How many clinical trials are currently recruiting for major depressive disorder?

ClinicalMetric currently tracks 29 actively recruiting clinical trials for major depressive disorder, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 29. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for major depressive disorder?

major depressive disorder research spans Phase 2 (3 trials), Phase 3 (1 trial), Phase 4 (6 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a major depressive disorder clinical trial?

Eligibility criteria for major depressive disorder trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

Phase 3

Phase 4

Top Sponsors

University of North Carolina, Chapel Hill 2 trials

Brigham and Women's Hospital 2 trials

Mclean Hospital 2 trials

Icahn School of Medicine at Mount Sinai 2 trials

National Institute on Drug Abuse (NIDA) 1 trial

major depressive disorder

Frequently Asked Questions — major depressive disorder Clinical Trials

Recruiting Clinical Trials

Defining Neurobiological Links Between Substance Use and Mental Illness

Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

Using TMS to Understand Neural Processes of Social Motivation

INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disorder

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

Combination of Novel Therapies for CKD Comorbid Depression

Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression

Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

Stress Dynamics and Familial Risk for Depression in Female Adolescents

Evaluation of a Male-specific Psychotherapeutic Program for Major Depressive Disorders

Maintenance rTMS for Depression (Maitr-De)

Pain and Major Depressive Disorder

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

Aβ Dynamics in LLMD

pBFS-guided rTMS Over DMPFC for Treatment-Resistant Depression

Personalized Indications for CBT and Antidepressants in Treating Depression

Self-Identification Program

CARED : A Novel Rapid Treatment Paradigm for Depression

Antidepressant Response of DMT Masked With Propofol

Chinese Longitudinal and Systematic Study of Bioplar Disorder

Neural Correlates of Stress and Perceived Control in Adolescent Depression

Behavioral Activation for Depression and Habitual Rumination

Natural History of Depression, Bipolar Disorder and Suicide Risk

A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

Treating Loneliness In The Older Adult With Depression With tDCS

Neural Circuit Effects of Ketamine in Depression

Accelerated TMS for Perinatal Depression

Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression

Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults