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Medical Condition

hypertension

Total Trials

61

Recruiting Now

61

Trial Phases

Phase 3, Phase 4, Phase 1, Phase 2

Hypertension remains the most common treatable cardiovascular risk factor globally, yet blood pressure control rates remain suboptimal despite multiple effective drug classes. Clinical trials now investigate novel mechanisms including aldosterone synthase inhibitors, renal denervation devices, and RNA-based therapies targeting angiotensinogen to achieve durable pressure reduction with minimal pill burden.

Active research includes zilebesiran (RNA interference targeting angiotensinogen), baxdrostat (aldosterone synthase inhibitor), ultrasound renal denervation (Symplicity HTN-4), and resistant hypertension approaches combining SGLT2 inhibitors with MRA spironolactone. Ambulatory blood pressure monitoring is increasingly used as the primary endpoint instead of clinic readings.

Frequently Asked Questions — hypertension Clinical Trials

How many clinical trials are currently recruiting for hypertension?

ClinicalMetric currently tracks 61 actively recruiting clinical trials for hypertension, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 61. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for hypertension?

hypertension research spans Phase 1 (5 trials), Phase 2 (5 trials), Phase 3 (3 trials), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a hypertension clinical trial?

Eligibility criteria for hypertension trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

5

Phase 2

5

Phase 3

3

Phase 4

3

Top Sponsors

Johns Hopkins University 3 trials

University of Minnesota 2 trials

Beth Israel Deaconess Medical Center 2 trials

University of Texas Southwestern Medical Center 2 trials

Aktiia SA 2 trials

Recruiting Clinical Trials

Assessment of Heart Rate Variability for Predicting Obstructive Sleep Apnea in Patients With Hypertension

Kaohsiung Armed Forces General...

NCT07080229 Phase 3

Intranasal Dexmedetomidine on Blood Pressure in Elderly Hypertensive Patients Undergoing Cataract Surgery

Suez Canal University

Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.

Heinrich-Heine University, Due...

A Registry Study on the "Action of Controlling Ambulatory Blood Pressure to Target in Ten Thousand Patients"

BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

United States, Austr...

Orchestra BioMed, Inc

Digital Care for Holistic Health in Older Adults With Diabetes and Multimorbidity

Chang Gung University of Scien...

NCT06256991 Phase 4

Potassium Correction for RAAS Optimization in Chronic Kidney Disease

University Medical Center Gron...

National Blood Pressure Screening in Children to Improve Paediatric Healthcare in South Africa

South Africa, Switze...

North-West University, South A...

Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

University of Minnesota

NCT05030545 Phase 4

Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

Brigham and Women's Hospital

NCT06025630 Phase 1, Phase 2

Targeting Endoplasmic Reticulum Stress in Human Hypertension

University of North Texas Heal...

Culturally Adapted Dietary Clinical Trial in PR

Harvard School of Public Healt...

Validation and Assessment of Novel Morphology-Voltage-P-wave Score for Diagnosing Left Ventricular Diastolic Dysfunction in Patients With Hypertension

Universitas Diponegoro

Safety of Etomidate-propofol Mixture vs. Propofol for Total Intravenous Anesthesia in Elderly Patients Undergoing Abdominal Surgery

Tongji Hospital

The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension

Johns Hopkins University

Optimizing Sustainable Cuff Access and Training Pathways for Self-Measured Blood Pressure Monitoring in Primary Care

Wake Forest University Health ...

The Effects of Dietary Nitrate in Patients With Hypertensive Kidney Injury

Gødstrup Hospital

NCT07482020 Phase 2

SGLT2i Improve Left Atrial Function in Patients With Paroxysmal Atrial Fibrillation, Hypertension and Abnormal Glucose Metabolism

Huashan Hospital

Medication Adherence Program

Tulane University

The "Global Paradise System" Registry

Austria, Belgium, Fr...

ReCor Medical, Inc.

A Cardiometabolic Health Program Linked With Clinical-Community Support and Mobile Health Telemonitoring to Reduce Health Disparities

Johns Hopkins University

NCT02608996 Phase 1, Phase 2

Nesiritide in Hypertension

Oslo University Hospital

Wearable Devices Empowering Active Health Initiatives for High-Risk Stroke Populations

Affiliated Hospital of Nantong...

Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

University of Tennessee

Remote Fetal Monitoring in High Risk Pregnancies

Beth Israel Deaconess Medical ...

Clinical Validation of the Blood Pressure Measuring Device Withings BPM Pro 2 in Pregnancy and Pre-Eclampsia

Hypertension Management in Young Adults Personalised by Echocardiography and Clinical Outcome.

University of Oxford

Rapid Management of Resistant Hypertension in the Public Health System (Fast Control)

Instituto Dante Pazzanese de C...

NCT04715022 Phase 1, Phase 2

Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)

University of Kansas Medical C...

Wearable Blood-Pressure Monitoring Comparison Study

Technische Universität Dresden

NCT07553442 Phase 2

A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran

Alnylam Pharmaceuticals

A Novel Rural Integrated Care and Early Prevention Model for Older Adults at High Risk of or Living With Stroke in China

Jiangsu Province (Suqian) Hosp...

County Medical Community-based, Cardiovascular Risk Stratified Integrated Care Model: a Pragmatic Cluster Randomised Control Trial

Peking University

Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients

Northwestern University

Preventing Cognitive Decline by Reducing BP Target Trial

University of Texas Southweste...

Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

Zeenat Qureshi Stroke Institut...

E3 Hypertension - A Team-based, Multidisciplinary Model in Addressing Barriers to Hypertension Control

Rush University Medical Center

Dynamic and Isometric Strength Training in Older Adults With Hypertension

Raphael Mendes Ritti Dias

Inspire HER: Inspiring the Heart and Emotions for Radical Health

University of Alabama at Birmi...

NCT04838678 EARLY_Phase 1

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

University of Texas Southweste...

Real World Evaluation of Lifelight®: A Contactless Vital Signs Monitor for Self-monitoring Blood Pressure and Its Comparison to Standard of Care

Groceries Plus Multi-Component Lifestyle Intervention for Adults With Hypertension and Type 2 Diabetes

Johns Hopkins University

NCT07064473 Phase 3

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

United States, Argen...

Boehringer Ingelheim

NCT06258473 Phase 1

Addressing Gaps in the Hypertension and Diabetes Care Continuum in Rural Bangladesh: The Dinajpur Study

BRAC University

Groceries for Residents of Southeastern USA to Stop Hypertension

Beth Israel Deaconess Medical ...

Examining the Circadian Timing Effects of the Hypotensive Response to Exercise

Freda Patterson

Effectiveness and Adoption of the TelTex4BP Intervention Among Adults With Hypertension in Nepal

Central Department of Public H...

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

National Institute of Diabetes...

Effect of Bariatric Surgery on Cardiac Function in Patients With Hypertension

Beijing Friendship Hospital

GlycOxiTOD: Multimodal Vascular and Target-Organ Damage Registry

Complejo Hospitalario Universi...

NCT06643130 Phase 3

Evaluate the Efficacy and Safety of Co-administration of JW0104+C2402 in Patients With Hypertension and Dyslipidemia

JW Pharmaceutical

Impact of Sleep-Disordered Breathing Management in Systemic Hypertension Control: METASLEEP Project

Sociedad Española de Neumologí...

OBPM_COYOTE2024 Physiological Data Recording With the Calibration-free Optical Aktiia G2C Device at Fingertip and Wrist, Alongside the Aktiia Oscillometric Cuff

Evaluation of the Clinical Benefit of the Aktiia Blood Pressure Monitoring for Early Awareness of Hypertension and Prediction of Cardiovascular Risk

Switzerland, United ...

A Study to Evaluate the Efficacy and Safety of Dapagliflozin in Patient With Type 2 Diabetes Mellitus and Hypertension

Boryung Pharmaceutical Co., Lt...

HOPE-BP 2.0: Evaluating the Optimal Duration of Postpartum Remote Blood Pressure Monitoring

University of Minnesota

A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects

Zona Health, Inc

Empowerment and Mobile Technology in the Control of Cardiovascular Risk Factors in Patients With Ischemic Stroke

Genetics in the Progression of Nephropathies

Ospedale San Raffaele

NCT05421767 Phase 4

Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation

National Taiwan University Hos...

Can TElemedicine System Replace Doctor Consultations to Achieve Non-inferior Blood Pressure in Patients With Controlled Hypertension

Chinese University of Hong Kon...

Related Conditions

cardiovascular diseases (8) diabetes (6) blood pressure (4) obesity (4) dyslipidemia (3) chronic kidney diseases (3) diabetes mellitus type 2 (3) stroke (3) obstructive sleep apnea (2) ckd (2) medication adherence (2) high blood pressure (2)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology