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Medical Condition

hypertension

Total Trials

55

Recruiting Now

55

Trial Phases

Phase 1, Phase 2, EARLY_Phase 1

Hypertension remains the most common treatable cardiovascular risk factor globally, yet blood pressure control rates remain suboptimal despite multiple effective drug classes. Clinical trials now investigate novel mechanisms including aldosterone synthase inhibitors, renal denervation devices, and RNA-based therapies targeting angiotensinogen to achieve durable pressure reduction with minimal pill burden.

Active research includes zilebesiran (RNA interference targeting angiotensinogen), baxdrostat (aldosterone synthase inhibitor), ultrasound renal denervation (Symplicity HTN-4), and resistant hypertension approaches combining SGLT2 inhibitors with MRA spironolactone. Ambulatory blood pressure monitoring is increasingly used as the primary endpoint instead of clinic readings.

Frequently Asked Questions — hypertension Clinical Trials

How many clinical trials are currently recruiting for hypertension?

ClinicalMetric currently tracks 55 actively recruiting clinical trials for hypertension, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 55. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for hypertension?

hypertension research spans Phase 1 (4 trials), Phase 2 (2 trials), Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a hypertension clinical trial?

Eligibility criteria for hypertension trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

4

Phase 2

2

Phase 4

2

Top Sponsors

Wake Forest University Health Sciences 2 trials

Aktiia SA 2 trials

University of Texas Southwestern Medical Center 2 trials

National Heart Centre Singapore 1 trial

Duke University 1 trial

Recruiting Clinical Trials

Response of the Myocardium to Hypertrophic Conditions in the Adult Population

National Heart Centre Singapor...

Community Park-Based Programs for Health Promotion: The Fit2Lead Prospective Cohort Study

Duke University

NCT05369065 Phase 1

Ablation of Arteries for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities

Neurotronic, Inc.

Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)

Wake Forest University Health ...

The "Check, Monitor, Control Hypertension" Study is a 24-month Randomized Trial in Houston Targeting African Americans Aged 55+. It Combines Pharmacist Counseling and CHW Support to Improve Blood Pressure Control in Hypertension Management.

Texas Southern University

BAROSTIM THERAPY™ In Resistant Hypertension

Germany, Netherlands

Effect of a Pharmacist-led Multifaceted Intervention on Treatment Outcomes in Hypertensive Patients

Xijing Hospital

Remote Fetal Monitoring in High Risk Pregnancies

Beth Israel Deaconess Medical ...

Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension

Australia, Belgium, ...

Medtronic Vascular

How Wall Squat Exercise Affects Blood Pressure in People With High Blood Pressure and Treated Sleep Apnea (WALLPRESS)

Aveiro University

A Novel Digital Tool Clinicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

University of Connecticut

Recording of Physiological Data Via an Optical Sensor At the Fingertip Alongside with Double Auscultatory and Pulse Oximetry to Evaluate the Effectiveness of an Optical Blood Pressure Monitoring (OBPM)

Effectiveness and Adoption of the TelTex4BP Intervention Among Adults With Hypertension in Nepal

Central Department of Public H...

Optical Coherence Tomography And NEphropathy: The OCTANE Study

University of Edinburgh

A Registry Study on the "Action of Controlling Ambulatory Blood Pressure to Target in Ten Thousand Patients"

Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

West Virginia School of Osteop...

Salt Sensitivity Evaluation Via N-of-1 Trials (SENSE-Salt)

Peking University

NCT07511361 Phase 2

Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension

Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women

São Paulo State University

Evaluating the Impact of a Functional and Cognitive Strategy in Patients With Long Covid-19

Fundación Cardioinfantil Insti...

A Real-world Study of the Effectiveness of Angiotensin Receptor-Neprilysin Inhibitor Therapy in Hypertensive Patients in the United Arab Emirates

United Arab Emirates

Novartis Pharmaceuticals

Genetics in the Progression of Nephropathies

Ospedale San Raffaele

OneSTOP (One-Stop Telehealth Obesity Program) for Multidisciplinary Weight Management and Related Comorbidities

Changi General Hospital

Assessing the Efficacy of Targeted Home Visits in the Management of Chronic Conditions

University of Texas Southweste...

GlycOxiTOD: Multimodal Vascular and Target-Organ Damage Registry

Complejo Hospitalario Universi...

SMBP Study: Improving High Blood Pressure in Older Adults With Multiple Chronic Diseases

"Smart Family Doctor" Assisted Comprehensive Management of Secondary Prevention Among Post Coronary Artery Bypass Graft Patients or Post Percutaneous Coronary Intervention Patients

China National Center for Card...

A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults

Cambridge University Hospitals...

NCT04838678 EARLY_Phase 1

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

University of Texas Southweste...

THE EFFECT OF EDUCATION IN PATIENTS WITH HYPERTENSION

Turkey (Türkiye)

Inonu University

Environment, Inflammation and Metabolic Diseases Study

NCT02966665 Phase 1

: Vascular Function in Health and Disease

Behavioral Interventions Combining AI/ML and Personalized Medicine to Reduce Cardiovascular Risk - Randomized Controlled Trial

National Bureau of Economic Re...

Preventative Screening and Health Coaching in a Food Insecure Population

Rush University Medical Center

Supporting VETerans With Kidney Disease Through Food As Medicine

VA Eastern Colorado Health Car...

Integrated Approach in Frail Older People with Atrial Fibrillation

Bulgaria, Denmark, I...

Heart Care Foundation

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

National Institute of Diabetes...

Penn Medicine Healthy Heart

University of Pennsylvania

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Johns Hopkins University

Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

Massachusetts General Hospital

Clinical Management of Cardiovascular Risk Factors in Adult Patients: A Before-and-After Interventional Study

Universidad Católica San Anton...

Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

Vanderbilt University Medical ...

Study on Blood Pressure Variability and Frailty in the Older People

Istituto Auxologico Italiano

Optimizing Sustainable Cuff Access and Training Pathways for Self-Measured Blood Pressure Monitoring in Primary Care

Wake Forest University Health ...

NCT06281665 Phase 4

Treatment With Aspirin After Preeclampsia: TAP Trial

Malamo Countouris

Jockey Club Precision Prevention Programme on Young Onset Diabetes

Juliana CN Chan

NCT06132477 Phase 4

Impact GLP-1 Agonists Following Bariatric

University of Missouri-Columbi...

Ketone Ester And Salt (KEAS) in Older Adults

Indiana University

Evaluation of the Clinical Benefit of the Aktiia Blood Pressure Monitoring for Early Awareness of Hypertension and Prediction of Cardiovascular Risk

Switzerland, United ...

Inorganic Nitrate Supplementation in Chronic Hypertensive Pregnancies

University of Sao Paulo

Exergaming Training Among Hypertensive Patients

Riphah International Universit...

iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic Diseases

Brazil, Chile, Costa...

Acupressure to Improve Insomnia Among the Elderly With Hypertension

Phenikaa University

Partners in Control, Phase II: Using Remote Monitoring Technology With Community Health Workers to Support Hypertension Management for Latinx Patients

NYU Langone Health

NCT07758634 Phase 1, Phase 2

A Trial Evaluating Safety, Tolerability and Efficacy of CTX340 in Participants With Hypertension

United States, Austr...

CRISPR Therapeutics AG

Related Conditions

diabetes mellitus (7) diabetes (6) obesity (6) cardiovascular diseases (4) heart failure (4) dyslipidemia (3) blood pressure (3) hyperlipidemias (3) left ventricular hypertrophy (2) anxiety (2) kidney diseases (2) vascular diseases (2)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology