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Medical Condition

hypertension

Total Trials

60

Recruiting Now

60

Trial Phases

Phase 3, Phase 1, Phase 4

Hypertension remains the most common treatable cardiovascular risk factor globally, yet blood pressure control rates remain suboptimal despite multiple effective drug classes. Clinical trials now investigate novel mechanisms including aldosterone synthase inhibitors, renal denervation devices, and RNA-based therapies targeting angiotensinogen to achieve durable pressure reduction with minimal pill burden.

Active research includes zilebesiran (RNA interference targeting angiotensinogen), baxdrostat (aldosterone synthase inhibitor), ultrasound renal denervation (Symplicity HTN-4), and resistant hypertension approaches combining SGLT2 inhibitors with MRA spironolactone. Ambulatory blood pressure monitoring is increasingly used as the primary endpoint instead of clinic readings.

Frequently Asked Questions — hypertension Clinical Trials

How many clinical trials are currently recruiting for hypertension?

ClinicalMetric currently tracks 60 actively recruiting clinical trials for hypertension, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 60. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for hypertension?

hypertension research spans Phase 1 (5 trials), Phase 2 (3 trials), Phase 3 (2 trials), Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a hypertension clinical trial?

Eligibility criteria for hypertension trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

5

Phase 2

3

Phase 3

2

Phase 4

2

Top Sponsors

China National Center for Cardiovascular Diseases 3 trials

Wake Forest University Health Sciences 2 trials

Vanderbilt University Medical Center 2 trials

Duke University 2 trials

AstraZeneca 1 trial

Recruiting Clinical Trials

Observational Study That Will Evaluate Treatment Patterns in the Management of Hypertension in the Public Primary Care System

Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

International Consortium of Ci...

Village-Based Management of Chronic Cardiovascular Disease in Qu Jiang Elderly Population Registry: The BOUQUET Cohort Study

Beijing Anzhen Hospital

Telehealth and Remote Blood Pressure

Wake Forest University Health ...

The SWITCH (Substitution of High With Low Ultra-processed Soy Protein Foods In a Guideline-based Diet inTervention for Cardiometabolic Health) Trial

University of Toronto

NCT06643130 Phase 3

Evaluate the Efficacy and Safety of Co-administration of JW0104+C2402 in Patients With Hypertension and Dyslipidemia

JW Pharmaceutical

Clinical Determinants and Adverse Reactions to Tropicamide/Phenylephrine in Hospitalized Patients.

Instituto de Oftalmología Fund...

Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood

University of Oxford

Nanshan Elderly Cohort Study

Sun Yat-sen University

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

National Institute of Diabetes...

Healthy Living Anson Study

University of North Carolina, ...

Systemic Arterial Hypertension in Pediatric Age.

IRCCS Azienda Ospedaliero-Univ...

Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy

NCT02646475 Phase 1

Metabolic Effects of Angiotensin-(1-7)

Vanderbilt University

NCT06258473 Phase 1

Addressing Gaps in the Hypertension and Diabetes Care Continuum in Rural Bangladesh: The Dinajpur Study

BRAC University

Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens

Shanghai Changzheng Hospital

Community-based Implementation of Adapted STAC

University of Wisconsin, Madis...

NCT07254481 Phase 1

VB19055 Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Healthy Chinese Population

Zhejiang Yangli Pharmaceutical...

My Interprofessional Care Team for Adherence and Research Engagement Disparities

University of Arizona

Examining Digital Health Care Delivery Models Through Medicaid Collaborative

OSF Healthcare System

Examining the Circadian Timing Effects of the Hypotensive Response to Exercise

Freda Patterson

Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics

First Affiliated Hospital Xi'a...

NCT05824923 Phase 3

A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hypertension Associated With Left Heart Failure

Pulnovo Medical (Wuxi) Co., Lt...

Integrated Diagnosis and Treatment of CKD on Outcomes

Capital Medical University

Gut Microbiota in Metabolic Surgery

Vanderbilt University Medical ...

Multi-center Study on New Cardiovascular Remodeling and Function Parameters in Hypertension

Qilu Hospital of Shandong Univ...

Implementation of Machine Learning and Hemodynamic Profiles Based Clinical Decision Support Systems for Personalized Guideline Accordant Antihypertensive Regimens in Primary Care: a Pragmatic Cluster Randomized Controlled Trial

China National Center for Card...

Partners in Control, Phase II: Using Remote Monitoring Technology With Community Health Workers to Support Hypertension Management for Latinx Patients

NYU Langone Health

NCT04715568 Phase 4

Secondhand Tobacco Smoke and Cardiovascular Disease

University of California, San ...

NCT05312892 Phase 1, Phase 2

Sympathetic Mechanisms in Obesity-Crossover Design

Vanderbilt University Medical ...

NCT05331144 Phase 2

Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)

Comparison of the Effects of Aerobic Exercise Training and Mat Pilates Exercise on Blood Pressure, Functional Capacity and Quality of Life in Hypertensive Individuals

Turkey (Türkiye)

Bezmialem Vakif University

"Smart Family Doctor" Assisted Comprehensive Management of Secondary Prevention Among Post Coronary Artery Bypass Graft Patients or Post Percutaneous Coronary Intervention Patients

China National Center for Card...

HOPE-BP 2.0: Evaluating the Optimal Duration of Postpartum Remote Blood Pressure Monitoring

University of Minnesota

Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)

Wake Forest University Health ...

Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease

Universidade Federal Fluminens...

Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women

São Paulo State University

Implementation and Evaluation of a Pharmacist-led Diabetes Care Pathway in Alberta Community Pharmacies

University of Alberta

Environment, Inflammation and Metabolic Diseases Study

Spyral InSight Study

Greece, Ireland

Medtronic Vascular

Community-based Approach to Lowering Stress Through Mindfulness

Northwestern University

Improving Hypertension Control in Rheumatoid Arthritis

Duke University

Accuracy Testing of Validated and Non-validated Home BP Devices Sold on the Online Market.

Centre Integre Universitaire d...

Performance of the Aktiia Optical Blood Pressure Monitoring Device Against Double Auscultation

Addressing Barriers to Achieving Cardiometabolic Disorders Prevention and Treatment Goals for PLWH in the SE US

Duke University

Optimizing Prescribing Decisions for Hospitalized Older Adults With Chronic Conditions

University of Pittsburgh

Clinical Validation of the Blood Pressure Measuring Device Withings BPM Pro 2 in Pregnancy and Pre-Eclampsia

Project 2: ACHIEVE- HF

Henry Ford Health System

Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

University of Massachusetts, B...

Effect of Sacubitril/Valsartan on Cardiac Function in Hypertensive Patients Stratified by BMI: A Real World Study

Beijing Friendship Hospital

Remote Fetal Monitoring in High Risk Pregnancies

Beth Israel Deaconess Medical ...

AM vs PM Exercise Training

Michigan State University

NCT05421767 Phase 4

Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation

National Taiwan University Hos...

NCT06025630 Phase 1, Phase 2

Targeting Endoplasmic Reticulum Stress in Human Hypertension

University of North Texas Heal...

Clinical Analysis of the Antihypertensive Effect of Laparoscopic Peripheral Nerve Blockade of the Renal Artery in Patients With Retroperitoneal Disease and Hypertension

Ruijin Hospital

Enhancing Intergenerational Health in Nigeria: Peripartum as Critical Life Stage for Cardiovascular Health

Washington University School o...

Prospective Exploratory Study on the Comprehensive Application Effectiveness of Exercise Prescription Decision Support Tools in the Management of Patients With "Four Highs" (Hypertension, Hyperglycemia, Hyperlipidemia, Hyperuricemia)

China National Center for Card...

National Blood Pressure Screening in Children to Improve Paediatric Healthcare in South Africa

South Africa, Switze...

North-West University, South A...

Dietary Strategies for Remission of Type 2 Diabetes

University of Bergen

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Johns Hopkins University

Related Conditions

cardiovascular diseases (7) diabetes (5) obesity (4) diabetes mellitus (4) heart failure (3) hypertension in pregnancy (3) dyslipidemia (3) vascular diseases (3) stroke (2) diabetes mellitus type 2 (2) metabolic syndrome (2) cancer (2)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology