Medical Condition

hypertension

Total Trials

51

Recruiting Now

51

Trial Phases

Phase 4, Phase 3, Phase 2

Hypertension remains the most common treatable cardiovascular risk factor globally, yet blood pressure control rates remain suboptimal despite multiple effective drug classes. Clinical trials now investigate novel mechanisms including aldosterone synthase inhibitors, renal denervation devices, and RNA-based therapies targeting angiotensinogen to achieve durable pressure reduction with minimal pill burden.

Active research includes zilebesiran (RNA interference targeting angiotensinogen), baxdrostat (aldosterone synthase inhibitor), ultrasound renal denervation (Symplicity HTN-4), and resistant hypertension approaches combining SGLT2 inhibitors with MRA spironolactone. Ambulatory blood pressure monitoring is increasingly used as the primary endpoint instead of clinic readings.

Frequently Asked Questions — hypertension Clinical Trials

How many clinical trials are currently recruiting for hypertension?

ClinicalMetric currently tracks 51 actively recruiting clinical trials for hypertension, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 51. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for hypertension?

hypertension research spans Phase 1 (1 trial), Phase 2 (3 trials), Phase 3 (2 trials), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a hypertension clinical trial?

Eligibility criteria for hypertension trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 3

Phase 4

Top Sponsors

Rush University Medical Center 2 trials

Istituto Auxologico Italiano 2 trials

Massachusetts General Hospital 2 trials

University of Sao Paulo 2 trials

Beth Israel Deaconess Medical Center 2 trials

hypertension

Frequently Asked Questions — hypertension Clinical Trials

Recruiting Clinical Trials

Treatment of Hypertension During Sleep

Improving Hypertension Control in Safety-Net Settings: The Boston Hypertension Equity Alliance in Treatment

Church-based Intervention to Improve Blood Pressure in African Americans

Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women

Telepharmacy on Patients With Arterial Hypertension

Integrated Diagnosis and Treatment of CKD on Outcomes

National Blood Pressure Screening in Children to Improve Paediatric Healthcare in South Africa

Preventing Cognitive Decline by Reducing BP Target Trial

RCT of Sensor-controlled Digital Game for Hypertension Self-care in a Native American Community

Goal Commitment and Proactive Health Behavior in Chronic Disease Patients

Clinical Response of EXTOR (Amlodipine/Valsartan) in Newly Diagnosed Hypertensive Patients.

Potassium Correction for RAAS Optimization in Chronic Kidney Disease

Safety and Efficacy of Ultrasound Renal Denervation in Kidney Transplantation Patients With Uncontrolled Hypertension

HTN App for HTN Control and Cardiovascular Health Among African-Americans

Examining the Feasibility of Implementing a Hypertension Storytelling Intervention Among African Americans

A Study to Evaluate Efficacy and Safety of HGP2102 in Essential Hypertension Patients

Adaptive Intervention Model for Hypertension Self-Management in Rural Areas: A Doctor-Patient Interaction Approach

OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)

Subendocardial Viability Ratio in Hypertension

Integrated Approach in Frail Older People with Atrial Fibrillation

A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects

Mobilizing Community Hypertension Access Pilot

Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation

Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia

A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran

Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure

Can TElemedicine System Replace Doctor Consultations to Achieve Non-inferior Blood Pressure in Patients With Controlled Hypertension

Study on Blood Pressure Variability and Frailty in the Older People

The Effects of Dietary Nitrate in Patients With Hypertensive Kidney Injury

Gut Microbiota in Metabolic Surgery

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

Jackson Heart Study Women's Hypertension Study

Nanshan Elderly Cohort Study

"Smart Family Doctor" Assisted Comprehensive Management of Secondary Prevention Among Post Coronary Artery Bypass Graft Patients or Post Percutaneous Coronary Intervention Patients

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

Nesiritide in Hypertension

Validation and Assessment of Novel Morphology-Voltage-P-wave Score for Diagnosing Left Ventricular Diastolic Dysfunction in Patients With Hypertension

Inorganic Nitrate Supplementation in Chronic Hypertensive Pregnancies

BRIDGE: Blood Pressure Reduction and Intervention Delivery Via Group Engagement

Oura Blood Pressure Profile Study

Mechanisms for Atrial Fibrillation in Obstructive Sleep Apnea

Steroids-Based Screening for Primary Aldosteronism

In-Hospital Detection of Elevated Blood Pressure

WeArable teChnology daTa driVen digitAl healTh cOachINg (ACTIVATION)- A Mixed-methods Study

Groceries for Residents of Southeastern USA to Stop Hypertension

Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

Remote Fetal Monitoring in High Risk Pregnancies

Impact of Eszopiclone on Blood Pressure in Patients With Insomnia and Hypertension (PRYSMA-HTN)

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Penn Medicine Healthy Heart