State MA
Clinical Trials in Massachusetts
Massachusetts is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Massachusetts and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 462 actively recruiting studies with Massachusetts sites out of 462 registered in total. The busiest research areas in Massachusetts are Acute Myeloid Leukemia, Breast Cancer, Prostate Cancer. Leading sponsors running trials in the state include Massachusetts General Hospital, Brigham and Women's Hospital, Boston Children's Hospital. By stage, Massachusetts trials break down as Phase 1 (86), Phase 2 (119), Phase 3 (87), Phase 4 (19).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Massachusetts
Frequently Asked Questions — Clinical Trials in Massachusetts
How many clinical trials are currently recruiting in Massachusetts?
ClinicalMetric currently tracks 462 actively recruiting clinical trials with at least one location in Massachusetts. The total number of registered studies—including active but not currently enrolling trials—is 462. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Massachusetts?
Massachusetts hosts clinical trials across a broad range of medical conditions, including Acute Myeloid Leukemia, Breast Cancer, Prostate Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Massachusetts serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Massachusetts?
To join a clinical trial in Massachusetts, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Massachusetts maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Massachusetts
NCT06986824 Phase 4
Recruiting
Perineal Massage Using A Pelvic Wand During Pregnancy
Condition
Pregnancy Related
Enrollment
140 pts
Location
United States
Sponsor
Beth Israel Deaconess Medical
NCT07165028 Phase 3
Recruiting
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associ...
Condition
Metabolic Dysfunction-Associated Steatotic Liver Disease
Enrollment
4,500 pts
Location
United States, Argentina, Australia
Sponsor
Eli Lilly and Company
NCT06324201 N/A
Recruiting
The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use i...
Condition
Paroxysmal Atrial Fibrillation
Enrollment
250 pts
Location
United States
Sponsor
Heart Rhythm Clinical and Rese
NCT04408430 N/A
Recruiting
The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).
Condition
Mitral Annular Calcification
Enrollment
210 pts
Location
United States, Mexico
Sponsor
Mayra Guerrero
NCT04299828 N/A
Recruiting
Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac...
Condition
Congenital Heart Disease
Enrollment
100 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT07588932 EARLY_Phase 1
Recruiting
Relying on Pharmacotherapy to Improve Motor Gains in Chronic Stroke Survivors
Condition
Stroke
Enrollment
50 pts
Location
United States
Sponsor
Spaulding Rehabilitation Hospi
NCT06469281 Phase 1
Recruiting
A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Ther...
Condition
Epithelial Ovarian Cancer
Enrollment
90 pts
Location
United States
Sponsor
Regeneron Pharmaceuticals
NCT07369128 Phase 4
Recruiting
Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Re...
Condition
MRI Sedation
Enrollment
105 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT04331639 N/A
Recruiting
High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel...
Condition
Inflammatory Bowel Disease
Enrollment
50 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT07533019 Phase 2
Recruiting
A Study of LY4005130 in Adult Participants With Non-Segmental Vitiligo
Condition
Vitiligo
Enrollment
66 pts
Location
United States, Belgium, Canada
Sponsor
Eli Lilly and Company
NCT05915299 N/A
Recruiting
US National OCS Heart Perfusion (OHP) Registry
Condition
Heart Transplant
Enrollment
100,000 pts
Location
United States
Sponsor
TransMedics
NCT04176198 Phase 1, Phase 2
Recruiting
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Condition
Myelofibrosis
Enrollment
240 pts
Location
United States, Australia, Belgium
Sponsor
Sumitomo Pharma America, Inc.
NCT07288398 Phase 3
Recruiting
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
Condition
Pulmonary Hypertension Associated With HFpEF
Enrollment
540 pts
Location
United States, Argentina, Austria
Sponsor
Tenax Therapeutics, Inc.
NCT00009633 N/A
Recruiting
Follow-up Visit of High Risk Infants
Condition
Infant, Newborn
Enrollment
68,000 pts
Location
United States
Sponsor
NICHD Neonatal Research Networ
NCT06055608 Phase 2
Recruiting
Advancing Transplantation Outcomes in Children
Condition
Kidney Transplant
Enrollment
200 pts
Location
United States
Sponsor
National Institute of Allergy
NCT06059638 N/A
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
Condition
Hypertension
Enrollment
316 pts
Location
United States, Australia, Belgium
Sponsor
Orchestra BioMed, Inc
NCT06472089 N/A
Recruiting
BMT-CARE: Psychosocial Intervention for Transplant Caregivers
Condition
Bone Marrow Transplant Complications
Enrollment
800 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT06095050 N/A
Recruiting
Embolization Treatment of Chronic Refractory Shoulder Tendinopathy
Condition
Shoulder Pain
Enrollment
41 pts
Location
United States
Sponsor
Brigham and Women's Hospital
NCT07513038 Phase 1, Phase 2
Recruiting
Use of Indocyanine Green (ICG) for the Diagnosis of Biliary Atresia
Condition
Biliary Atresia
Enrollment
20 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT06960616 N/A
Recruiting
Improving Clinical Efficiency by Reducing Scheduled Follow-ups Using Cochlear Am...
Condition
Deafness
Enrollment
48 pts
Location
United States
Sponsor
Massachusetts Eye and Ear Infi
NCT03595917 Phase 1
Recruiting
ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML
Condition
B-cell Acute Lymphoblastic Leukemia
Enrollment
40 pts
Location
United States
Sponsor
Marlise Luskin, MD
NCT01524276 N/A
Recruiting
Product Surveillance Registry
Condition
Cardiac Rhythm Disorders
Enrollment
100,000 pts
Location
United States, Argentina, Australia
Sponsor
Medtronic
NCT07218926 Phase 3
Recruiting
A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastr...
Condition
Gastrointestinal Neoplasms
Enrollment
450 pts
Location
United States, Australia, Belgium
Sponsor
GlaxoSmithKline
NCT07330778 Phase 1
Recruiting
A Study of CDX-622 in Participants With Mild to Moderate Asthma
Condition
Mild to Moderate Asthma
Enrollment
12 pts
Location
United States
Sponsor
Celldex Therapeutics
NCT06311708 N/A
Recruiting
Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Ad...
Condition
Arrhythmogenic Right Ventricular Cardiomyopathy
Enrollment
200 pts
Location
United States, France, Germany
Sponsor
Tenaya Therapeutics
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology