State MA
Clinical Trials in Massachusetts
Massachusetts is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Massachusetts and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 495 actively recruiting studies with Massachusetts sites out of 495 registered in total. The busiest research areas in Massachusetts are Acute Myeloid Leukemia, Breast Cancer, Solid Tumor. Leading sponsors running trials in the state include Massachusetts General Hospital, Brigham and Women's Hospital, Boston Children's Hospital. By stage, Massachusetts trials break down as Phase 1 (91), Phase 2 (141), Phase 3 (99), Phase 4 (19).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Massachusetts
Frequently Asked Questions — Clinical Trials in Massachusetts
How many clinical trials are currently recruiting in Massachusetts?
ClinicalMetric currently tracks 495 actively recruiting clinical trials with at least one location in Massachusetts. The total number of registered studies—including active but not currently enrolling trials—is 495. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Massachusetts?
Massachusetts hosts clinical trials across a broad range of medical conditions, including Acute Myeloid Leukemia, Breast Cancer, Solid Tumor, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Massachusetts serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Massachusetts?
To join a clinical trial in Massachusetts, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Massachusetts maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Massachusetts
NCT04991922 N/A
Recruiting
BostonGene-Integrated Genomic Registry (BIGR)
Condition
Malignancy
Enrollment
100,000 pts
Location
United States
Sponsor
BostonGene
NCT07701941 Phase 1, Phase 2
Recruiting
A Study of Patritumab Deruxtecan (HER3-DXd) in Combination With Trastuzumab Deru...
Condition
Hormone Receptor Positive
Enrollment
220 pts
Location
United States, Belgium, France
Sponsor
Daiichi Sankyo
NCT07087431 N/A
Recruiting
Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascu...
Condition
Coronary Artery Disease
Enrollment
500 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT05732831 Phase 1, Phase 2
Recruiting
Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors
Condition
Locally Advanced Solid Tumor
Enrollment
225 pts
Location
United States, France, Spain
Sponsor
Tango Therapeutics, Inc.
NCT06195072 Phase 2
Recruiting
Platform Clinical Study for Conquering Scleroderma
Condition
Interstitial Lung Disease Due to Systemic Disease
Enrollment
400 pts
Location
United States
Sponsor
Scleroderma Research Foundatio
NCT06423430 N/A
Recruiting
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Condition
Treatment Resistant Depression
Enrollment
100 pts
Location
United States
Sponsor
Abbott Medical Devices
NCT07173751 Phase 3
Recruiting
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-N...
Condition
Breast Neoplasms
Enrollment
558 pts
Location
United States, Argentina, Australia
Sponsor
BioNTech SE
NCT07489495 Phase 3
Recruiting
A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal ...
Condition
Carcinoma, Renal Cell
Enrollment
758 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
NCT07406633 Phase 2
Recruiting
KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIS...
Condition
GIST - Gastrointestinal Stromal Tumor
Enrollment
46 pts
Location
United States
Sponsor
Kumquat Biosciences Inc.
NCT00898235 N/A
Recruiting
Collection of Samples and Clinical Data From Patients With Amyloid Diseases
Condition
Multiple Myeloma
Enrollment
10,000 pts
Location
United States
Sponsor
Boston Medical Center
NCT07484217 Phase 3
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Slee...
Condition
Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms
Enrollment
508 pts
Location
United States
Sponsor
Axsome Therapeutics, Inc.
NCT04900597 N/A
Recruiting
Effect of Blenderized Enteral Tube Feeds on Pediatric Upper Gastrointestinal Tra...
Condition
Enteral Feeding Intolerance
Enrollment
45 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT06848140 N/A
Recruiting
Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic...
Condition
Traumatic Brain Injury
Enrollment
14 pts
Location
United States
Sponsor
Beth Israel Deaconess Medical
NCT02493478 N/A
Recruiting
Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs
Condition
Failed or Difficult Intubation, Sequela
Enrollment
150,000 pts
Location
United States, Australia, Austria
Sponsor
Children's Hospital of Philade
NCT06964685 N/A
Recruiting
Assessment of Support With Impella® Best Practices in Acute Myocardial Infarctio...
Condition
AMI Cardiogenic Shock
Enrollment
350 pts
Location
United States
Sponsor
Abiomed Inc.
NCT06986174 Phase 2
Recruiting
A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or...
Condition
Waldenström Macroglobulinemia
Enrollment
30 pts
Location
United States
Sponsor
Shayna Sarosiek, MD
NCT05573074 N/A
Recruiting
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
Condition
Major Depressive Disorder
Enrollment
120 pts
Location
United States
Sponsor
NYU Langone Health
NCT07377747 N/A
Recruiting
Prospective Study Evaluating the Treatment Outcomes for Localised Recurrent, Res...
Condition
Retroperitoneal Liposarcoma
Enrollment
100 pts
Location
United States, Australia, Belgium
Sponsor
Australia and New Zealand Sarc
NCT07082738 Phase 2
Recruiting
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Ve...
Condition
Chronic Obstructive Pulmonary Disease (COPD)
Enrollment
987 pts
Location
United States, Argentina, Australia
Sponsor
AstraZeneca
NCT07444476 Phase 3
Recruiting
A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety...
Condition
Spinal Muscular Atrophy
Enrollment
90 pts
Location
United States, China, Japan
Sponsor
Biogen
NCT05065216 Phase 2, Phase 3
Recruiting
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
Condition
Acute Stroke
Enrollment
728 pts
Location
United States, Belgium, Canada
Sponsor
DiaMedica Therapeutics Inc
NCT06930625 Phase 3
Recruiting
A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acr...
Condition
Acromegaly
Enrollment
119 pts
Location
United States, Austria, Belgium
Sponsor
Debiopharm International SA
NCT07536906 N/A
Recruiting
Falls Validation Study
Condition
Intracranial Bleed
Enrollment
4,000 pts
Location
United States, Canada
Sponsor
Dr. Kerstin de Wit
NCT07213804 Phase 3
Recruiting
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum...
Condition
Ovarian Neoplasms
Enrollment
1,630 pts
Location
United States, Australia, Austria
Sponsor
Eli Lilly and Company
NCT07735624 Phase 2
Recruiting
RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal Cance...
Condition
Early Rectal Cancer
Enrollment
16 pts
Location
United States
Sponsor
Dana-Farber Cancer Institute
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology