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advanced solid tumors

Total Trials
35
Recruiting Now
35
Trial Phases
Phase 1, Phase 1, Phase 2, Phase 2

ClinicalMetric tracks all active clinical trials for advanced solid tumors sourced from ClinicalTrials.gov. Each listing includes the NCT identifier, current recruitment status, phase, primary endpoints, sponsor, estimated enrollment, and participating countries — updated daily as new studies open and status changes.

  • Recruiting trials currently enrolling participants, with eligibility criteria and age requirements
  • Phase 1–4 studies from early safety trials to post-marketing surveillance
  • NIH, pharmaceutical sponsor, and academic medical center studies worldwide
  • AI-powered plain-language summary available for every trial listing

Frequently Asked Questions — advanced solid tumors Clinical Trials

How many clinical trials are currently recruiting for advanced solid tumors?
ClinicalMetric currently tracks 35 actively recruiting clinical trials for advanced solid tumors, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 35. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for advanced solid tumors?
advanced solid tumors research spans Phase 1 (32 trials), Phase 2 (10 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a advanced solid tumors clinical trial?
Eligibility criteria for advanced solid tumors trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
32
Phase 2
10
Top Sponsors
Eikon Therapeutics 2 trials
Astellas Pharma Global Development, Inc. 1 trial
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. 1 trial
Shanghai Hengrui Pharmaceutical Co., Ltd. 1 trial
ModernaTX, Inc. 1 trial

Recruiting Clinical Trials

NCT05719558 Phase 1
Recruiting

A Study of ASP1002 in Adults for Treatment of Solid Tumors

Enrollment
210 pts
Location
United States
Sponsor
Astellas Pharma Global Develop...
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NCT06826040 Phase 1
Recruiting

SKB445 for Injection in Solid Tumors

Enrollment
126 pts
Location
China
Sponsor
Sichuan Kelun-Biotech Biopharm...
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NCT06439589 Phase 1, Phase 2
Recruiting

Phase Ib/II Study of HRS2398 in Combination With Adebrelimab in Patients With Advanced Solid Tumors

Enrollment
88 pts
Location
China
Sponsor
Shanghai Hengrui Pharmaceutica...
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NCT05533697 Phase 1, Phase 2
Recruiting

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

Enrollment
361 pts
Location
United States, Austr...
Sponsor
ModernaTX, Inc.
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NCT06596473 Phase 1
Recruiting

A Study of BG-C477 in Participants With Advanced Solid Tumors

Enrollment
310 pts
Location
United States, Austr...
Sponsor
BeOne Medicines
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NCT05881525 Phase 1
Recruiting

NY-ESO-1 TCR-T Cells for NY-ESO-1 Positive Subjects With Advanced Solid Tumors

Enrollment
18 pts
Location
China
Sponsor
TCRCure Biopharma Ltd.
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NCT05941507 Phase 1, Phase 2
Recruiting

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

Enrollment
300 pts
Location
United States, Canad...
Sponsor
LigaChem Biosciences, Inc.
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NCT07413328 Phase 1
Recruiting

HWS116 Monotherapy in Patients With Advanced Solid Tumors

Enrollment
56 pts
Location
China
Sponsor
Wuhan Humanwell Innovative Dru...
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NCT06973564 Phase 1, Phase 2
Recruiting

JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

Enrollment
294 pts
Location
United States
Sponsor
Jacobio Pharmaceuticals Co., L...
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NCT07046650 Phase 2
Recruiting

Multi-cohort, Single-arm, Phase II Study of the Efficacy and Side Effects of Cisplatin Plus Gemcitabine in the Treatment of PD1 Failure or Intensive Treatment of Some Rare Tumors

Enrollment
84 pts
Location
China
Sponsor
Sheng Zhang
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NCT07262619 Phase 1, Phase 2
Recruiting

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

Enrollment
160 pts
Location
United States, Austr...
Sponsor
Eikon Therapeutics
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NCT07042100 Phase 1
Recruiting

A Study to Test the Safety and Tolerability of SBO-154 in Patients With Advanced Solid Tumors.

Enrollment
177 pts
Location
United States, Austr...
Sponsor
Sun Pharma Advanced Research C...
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NCT07346846 Phase 1
Recruiting

A Study of BGM-2121 in Patients With Advanced Solid Tumors

Enrollment
35 pts
Location
Taiwan
Sponsor
BioGate Precision Medicine Cor...
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NCT06376136 Phase 1, Phase 2
Recruiting

A Multicenter Open Clinical Study of Safety, Tolerability, Pharmacokinetic Profile, and Initial Clinical Efficacy of BAT 8010 for Injection Combined With BAT 1006 in the Treatment of Locally Advanced or Metastatic Tumors

Enrollment
216 pts
Location
China
Sponsor
Bio-Thera Solutions
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NCT07215637 Phase 1
Recruiting

Phase Ia/Ib Study of CKD-512 Alone and in Combination With Pembrolizumab in Subjects With Advanced or Metastatic Solid Tumors

Enrollment
60 pts
Location
South Korea
Sponsor
Chong Kun Dang Pharmaceutical
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NCT06907043 Phase 1, Phase 2
Recruiting

A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.

Enrollment
130 pts
Location
United States, Austr...
Sponsor
Eikon Therapeutics
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NCT07349160 EARLY_Phase 1
Recruiting

Safety and Efficacy of Metabolically Armed Tumor-Infiltrating Lymphocytes (Meta10-TIL) for the Treatment of Advanced Solid Tumors

Enrollment
36 pts
Location
China
Sponsor
Cancer Institute and Hospital,...
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NCT05836324 Phase 1
Recruiting

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

Enrollment
408 pts
Location
United States, Denma...
Sponsor
Incyte Corporation
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NCT06004245 Phase 1
Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

Enrollment
280 pts
Location
United States, Austr...
Sponsor
Vividion Therapeutics, Inc.
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NCT07208136 Phase 1
Recruiting

A Study of JMKX005425 in Patients With MSI-H/dMMR Advanced Solid Tumors

Enrollment
102 pts
Location
China
Sponsor
Jemincare
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NCT07185243
Recruiting

A Study to Evaluate Combination Therapy of Oncolytic Vaccinia Virus (hV01) and PD-1 Inhibitor in Advanced Solid Tumors.

Enrollment
24 pts
Location
China
Sponsor
Hangzhou Converd Co., Ltd.
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NCT06384352 Phase 1
Recruiting

A Phase I Study to Evaluate the Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors

Enrollment
155 pts
Location
United States, Austr...
Sponsor
MediLink Therapeutics (Suzhou)...
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NCT07229898 Phase 1
Recruiting

A Phase Ⅰ Clinical Study of GEN-725 Tablets in Patients With Advanced Solid Tumors

Enrollment
48 pts
Location
China
Sponsor
Henan Genuine Biotech Co., Ltd...
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NCT06990698 Phase 1
Recruiting

A Phase 1 Study to Investigate FP008 in Subjects With Advanced Solid Tumors

Enrollment
108 pts
Location
China
Sponsor
Zhuhai Fapon Biopharma Co., Lt...
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NCT06822998 EARLY_Phase 1
Recruiting

HF50 in HER-2 Positive and Low-expression Advanced Solid Tumors

Enrollment
10 pts
Location
China
Sponsor
HighField Biopharmaceuticals C...
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NCT06764836 Phase 1
Recruiting

A Study of IMM2510 + IMM27M Combination Therapy in Patients With Advanced Solid Tumors

Enrollment
108 pts
Location
China
Sponsor
ImmuneOnco Biopharmaceuticals ...
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NCT07372625 Phase 1
Recruiting

A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

Enrollment
14 pts
Location
United States
Sponsor
PMV Pharmaceuticals, Inc
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NCT07310134 Phase 1
Recruiting

Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of ZX-8177 in Patients With Advanced Solid Tumors

Enrollment
80 pts
Location
China
Sponsor
Nanjing Zenshine Pharmaceutica...
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NCT06824155 EARLY_Phase 1
Recruiting

HEAT Trial (HER2 Antibody Therapy With Lutetium-177)

Enrollment
30 pts
Location
Australia
Sponsor
Radiopharm Theranostics, Ltd
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NCT07359066 Phase 1, Phase 2
Recruiting

An Open-label, First-in-Human, Dose-Escalation and Dose-Expansion Phase I/II Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPR1020 in Patients With Advanced Solid Tumors

Enrollment
210 pts
Location
China
Sponsor
Shanghai SciBrunch Therapeutic...
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NCT03297606 Phase 2
Recruiting

Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)

Enrollment
720 pts
Location
Canada
Sponsor
Canadian Cancer Trials Group
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NCT06993870 Phase 1
Recruiting

Phase I Study of HBT-708 for Patients With Advanced Solid Tumors

Enrollment
60 pts
Location
China
Sponsor
Shenyang Sunshine Pharmaceutic...
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NCT05564858 Phase 1
Recruiting

A Study of FDA022-BB05 in Subjects With Advanced Solid Malignant Tumors

Enrollment
107 pts
Location
China
Sponsor
Shanghai Fudan-Zhangjiang Bio-...
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NCT06770569 Phase 1
Recruiting

A Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HRS-3802 Monotherapy in Patients With Malignant Solid Tumors

Enrollment
100 pts
Location
Australia, China
Sponsor
Shandong Suncadia Medicine Co....
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NCT07356453 Phase 1
Recruiting

A Study of PARG Inhibitor FORX-428 in Patients With Advanced Solid Tumors.

Enrollment
40 pts
Location
United States
Sponsor
FoRx Therapeutics AG
View Trial →
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology