State MA
Clinical Trials in Massachusetts
Massachusetts is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Massachusetts and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 474 actively recruiting studies with Massachusetts sites out of 474 registered in total. The busiest research areas in Massachusetts are Prostate Cancer, Colorectal Cancer, Breast Cancer. Leading sponsors running trials in the state include Massachusetts General Hospital, Brigham and Women's Hospital, Boston Children's Hospital. By stage, Massachusetts trials break down as Phase 1 (86), Phase 2 (125), Phase 3 (78), Phase 4 (14).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Massachusetts
Frequently Asked Questions — Clinical Trials in Massachusetts
How many clinical trials are currently recruiting in Massachusetts?
ClinicalMetric currently tracks 474 actively recruiting clinical trials with at least one location in Massachusetts. The total number of registered studies—including active but not currently enrolling trials—is 474. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Massachusetts?
Massachusetts hosts clinical trials across a broad range of medical conditions, including Prostate Cancer, Colorectal Cancer, Breast Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Massachusetts serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Massachusetts?
To join a clinical trial in Massachusetts, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Massachusetts maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Massachusetts
NCT07190196 Phase 3
Recruiting
A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adul...
Condition
Immunoglobulin G4 Related Disease
Enrollment
124 pts
Location
United States, Argentina, Belgium
Sponsor
Sanofi
NCT05188183 N/A
Recruiting
Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain ...
Condition
Phantom Limb Pain
Enrollment
290 pts
Location
United States
Sponsor
Spaulding Rehabilitation Hospi
NCT06089083 N/A
Recruiting
PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recover...
Condition
Malignant Female Reproductive System Neoplasm
Enrollment
500 pts
Location
United States
Sponsor
University of California, San
NCT05796375 Phase 2
Recruiting
Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder...
Condition
Non-muscle-invasive Bladder Cancer
Enrollment
240 pts
Location
United States
Sponsor
White River Junction Veterans
NCT07221357 Phase 2, Phase 3
Recruiting
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Che...
Condition
Untreated, Unresectable, or Metastatic Colorectal Cancer
Enrollment
990 pts
Location
United States, Argentina, Australia
Sponsor
Bristol-Myers Squibb
NCT04940663 N/A
Recruiting
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental ...
Condition
Psychosis
Enrollment
120 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT07464093 N/A
Recruiting
STABLE Pilates for Hypermobility
Condition
Ehlers-Danlos Syndrome (EDS)
Enrollment
100 pts
Location
United States
Sponsor
Brigham and Women's Hospital
NCT04640584 N/A
Recruiting
C-Brace Prospective Registry
Condition
Pareses
Enrollment
250 pts
Location
United States, Australia, Germany
Sponsor
Otto Bock Healthcare Products
NCT04065399 Phase 1, Phase 2
Recruiting
A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rea...
Condition
Acute Myeloid Leukemia
Enrollment
447 pts
Location
United States, Australia, Canada
Sponsor
Syndax Pharmaceuticals
NCT07766005 Phase 2
Recruiting
A Study of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa (Th...
Condition
Hidradenitis Suppurativa (HS)
Enrollment
150 pts
Location
United States, Canada
Sponsor
Spyre Therapeutics, Inc.
NCT07219537 N/A
Recruiting
A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule
Condition
Lynch Syndrome
Enrollment
30 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT07231419 Phase 3
Recruiting
Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With ...
Condition
Diabetic Peripheral Neuropathic Pain
Enrollment
734 pts
Location
United States
Sponsor
Vertex Pharmaceuticals Incorpo
NCT05915377 N/A
Recruiting
Researching Efficient Approaches to Delirium Identification-Sustaining Effective...
Condition
Delirium
Enrollment
1,050 pts
Location
United States
Sponsor
Penn State University
NCT06517901 N/A
Recruiting
Fusion or Cognitive Ultrasound-guided Biopsy to Detect Prostate Cancer
Condition
Prostate Cancer
Enrollment
1,306 pts
Location
United States, Canada
Sponsor
Albany Medical College
NCT06963034 Phase 3
Recruiting
NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizoph...
Condition
Schizophrenia
Enrollment
284 pts
Location
United States
Sponsor
Neurocrine Biosciences
NCT05919264 Phase 1, Phase 2
Recruiting
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Condition
Cancer
Enrollment
619 pts
Location
United States, Australia
Sponsor
Parabilis Medicines, Inc.
NCT04629014 N/A
Recruiting
Prospective Multisite Study of Quality of Life in Pediatric Intestinal Failure
Condition
Pediatric Intestinal Failure
Enrollment
750 pts
Location
United States, Canada
Sponsor
Boston Children's Hospital
NCT02744677 N/A
Recruiting
COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients...
Condition
Complex Congenital Heart Defect
Enrollment
108 pts
Location
United States
Sponsor
Edwards Lifesciences
NCT07337577 N/A
Recruiting
Targeted Artificial Intelligence Language mOdel Recommendations for Heart Failur...
Condition
Heart Failure
Enrollment
500 pts
Location
United States
Sponsor
Brigham and Women's Hospital
NCT04047628 Phase 3
Recruiting
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for ...
Condition
Relapsing Multiple Sclerosis
Enrollment
156 pts
Location
United States
Sponsor
National Institute of Allergy
NCT06307665 Phase 3
Recruiting
Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As ...
Condition
Asthma
Enrollment
440 pts
Location
United States, China, Mexico
Sponsor
AstraZeneca
NCT04115254 N/A
Recruiting
Stereotactic Magnetic Resonance Guided Radiation Therapy
Condition
Pancreas Cancer
Enrollment
397 pts
Location
United States
Sponsor
Dana-Farber Cancer Institute
NCT06657222 Phase 1, Phase 2
Recruiting
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
Condition
Advanced Solid Tumors
Enrollment
250 pts
Location
United States, Canada, France
Sponsor
Gilead Sciences
NCT04554212 N/A
Recruiting
Blood Flow Restriction Training After Patellar INStability
Condition
Patellar Dislocation
Enrollment
78 pts
Location
United States
Sponsor
Caitlin Conley
NCT07175428 Phase 2
Recruiting
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Antic...
Condition
Atrial Fibrillation (AF)
Enrollment
1,200 pts
Location
United States, Argentina, Brazil
Sponsor
Regeneron Pharmaceuticals
Page 1 of 19 — 474 trials total
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology