State MA
Clinical Trials in Massachusetts
Massachusetts is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Massachusetts and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 443 actively recruiting studies with Massachusetts sites out of 443 registered in total. The busiest research areas in Massachusetts are Breast Cancer, Prostate Cancer, Ovarian Cancer. Leading sponsors running trials in the state include Massachusetts General Hospital, Brigham and Women's Hospital, Boston Children's Hospital. By stage, Massachusetts trials break down as Phase 1 (81), Phase 2 (114), Phase 3 (80), Phase 4 (15).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Massachusetts
Frequently Asked Questions — Clinical Trials in Massachusetts
How many clinical trials are currently recruiting in Massachusetts?
ClinicalMetric currently tracks 443 actively recruiting clinical trials with at least one location in Massachusetts. The total number of registered studies—including active but not currently enrolling trials—is 443. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Massachusetts?
Massachusetts hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Prostate Cancer, Ovarian Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Massachusetts serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Massachusetts?
To join a clinical trial in Massachusetts, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Massachusetts maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Massachusetts
NCT06860516 N/A
Recruiting
HLA Demographics Study in Adults With Type 1 Diabetes
Condition
Diabetes Mellitus, Type I
Enrollment
200 pts
Location
United States
Sponsor
GentiBio, Inc
NCT06982521 Phase 3
Recruiting
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatme...
Condition
PIK3CA Mutation
Enrollment
540 pts
Location
United States, Argentina, Australia
Sponsor
Relay Therapeutics, Inc.
NCT05236062 N/A
Recruiting
Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD...
Condition
Graft Vs Host Disease
Enrollment
36 pts
Location
United States
Sponsor
Dana-Farber Cancer Institute
NCT07100379 N/A
Recruiting
Balloon Inflation Time for Esophageal Strictures (BITES): A Randomized Multi-Cen...
Condition
Esophageal Atresia With Tracheo-esophageal Fistula
Enrollment
128 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT07244263 Phase 2
Recruiting
A Study of Zasocitinib in Adults With Hidradenitis Suppurativa
Condition
Hidradenitis Suppurativa
Enrollment
90 pts
Location
United States, Australia, Canada
Sponsor
Takeda
NCT04026893 N/A
Recruiting
Deceased Uterine Transplant in Absolute Uterine Infertility (AUIF)
Condition
Infertility of Uterine Origin
Enrollment
250 pts
Location
United States
Sponsor
Brigham and Women's Hospital
NCT05006131 N/A
Recruiting
Pancreatic Cancer Screening for At-risk Individuals
Condition
Pancreatic Cancer, Adult
Enrollment
1,395 pts
Location
United States
Sponsor
Beth Israel Deaconess Medical
NCT03127267 Phase 3
Recruiting
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
Condition
Amyotrophic Lateral Sclerosis
Enrollment
495 pts
Location
United States, Belgium, Denmark
Sponsor
AB Science
NCT05729607 N/A
Recruiting
Vertical Soft Tissue Augmentation With CTG vs ADM
Condition
Implant Complication
Enrollment
28 pts
Location
United States
Sponsor
Harvard Medical School (HMS an
NCT06538636 N/A
Recruiting
Prediction Augmented Screening Initiative
Condition
Lung Cancer
Enrollment
23,520 pts
Location
United States
Sponsor
VA Office of Research and Deve
NCT06945614 Phase 1
Recruiting
Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation...
Condition
Healthy Volunteer Study
Enrollment
16 pts
Location
United States
Sponsor
General Biophysics LLC
NCT06075693 N/A
Recruiting
Cerebrospinal Fluid Biomarkers of Myotonic Dystrophy
Condition
Myotonic Dystrophy Type 1
Enrollment
88 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT06843447 Phase 1, Phase 2
Recruiting
A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-590...
Condition
Ovarian Cancer Recurrent
Enrollment
460 pts
Location
United States, Canada, Israel
Sponsor
Merck Sharp & Dohme LLC
NCT06710548 N/A
Recruiting
REVITALIZE: RCT to Reduce Fatigue in Adults With Ovarian Cancer on PARP Inhibito...
Condition
Ovarian Cancer
Enrollment
240 pts
Location
United States
Sponsor
Dana-Farber Cancer Institute
NCT05375643 N/A
Recruiting
SURGE: Supporting UnderRepresented Minorities in Genomics-based Cancer Trial Enr...
Condition
Gastrointestinal Cancer
Enrollment
210 pts
Location
United States
Sponsor
Nadine McCleary, MD, MPH
NCT07038343 Phase 1, Phase 2
Recruiting
AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in P...
Condition
Solid Tumor Cancer
Enrollment
480 pts
Location
United States
Sponsor
Avenzo Therapeutics, Inc.
NCT07054073 N/A
Recruiting
HCMR Re-Imaging Study
Condition
Hypertrophic Cardiomyopathy (HCM)
Enrollment
314 pts
Location
United States, United Kingdom
Sponsor
Christopher Kramer
NCT04101669 N/A
Recruiting
RESET System Pivotal Trial (Rev F)
Condition
Diabetes type2
Enrollment
264 pts
Location
United States
Sponsor
Morphic Medical Inc.
NCT05372354 Phase 1, Phase 2
Recruiting
A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-98634...
Condition
Multiple Myeloma
Enrollment
260 pts
Location
United States, Canada, Norway
Sponsor
Bristol-Myers Squibb
NCT06420375 Phase 2
Recruiting
Treatment of UC With Novel Therapeutics
Condition
Ulcerative Colitis Mild
Enrollment
20 pts
Location
United States
Sponsor
Brigham and Women's Hospital
NCT07215273 Phase 2
Recruiting
Phase 2 EL219 Versus Liposomal Amphotericin B or Voriconazole for Early Antifung...
Condition
Invasive Mould Infection
Enrollment
60 pts
Location
United States, Belgium, Canada
Sponsor
Elion Therapeutics, Inc.
NCT04925375 Phase 2
Recruiting
Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitia...
Condition
Interstitial Lung Disease
Enrollment
38 pts
Location
United States
Sponsor
Children's Hospital Medical Ce
NCT04875429 N/A
Recruiting
Zenith® Fenestrated+ Clinical Study
Condition
Aortic Aneurysm, Abdominal
Enrollment
105 pts
Location
United States, United Kingdom
Sponsor
Cook Research Incorporated
NCT06909695 N/A
Recruiting
Influences of Long-acting Reversible Contraceptives on Iron Status and Physiolog...
Condition
Contraception
Enrollment
33 pts
Location
United States
Sponsor
United States Army Research In
NCT07006675 Phase 3
Recruiting
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Frac...
Condition
Tibial Fractures
Enrollment
1,000 pts
Location
United States, Canada
Sponsor
Major Extremity Trauma Researc
Page 1 of 18 — 443 trials total
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology