State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 406 actively recruiting studies with Illinois sites out of 406 registered in total. The busiest research areas in Illinois are Ovarian Cancer, Breast Cancer, Prostate Cancer. Leading sponsors running trials in the state include University of Chicago, Northwestern University, National Cancer Institute (NCI). By stage, Illinois trials break down as Phase 1 (66), Phase 2 (130), Phase 3 (103), Phase 4 (13).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 406 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 406. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Ovarian Cancer, Breast Cancer, Prostate Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT07406633 Phase 2
Recruiting
KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIS...
Condition
GIST - Gastrointestinal Stromal Tumor
Enrollment
46 pts
Location
United States
Sponsor
Kumquat Biosciences Inc.
NCT07484217 Phase 3
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Slee...
Condition
Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms
Enrollment
508 pts
Location
United States
Sponsor
Axsome Therapeutics, Inc.
NCT07003425 Phase 2
Recruiting
A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis
Condition
Atopic Dermatitis
Enrollment
350 pts
Location
United States, Canada, Czechia
Sponsor
Apogee Therapeutics, Inc.
NCT07276997 Phase 2
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcapr...
Condition
Major Depressive Disorder
Enrollment
195 pts
Location
United States
Sponsor
AbbVie
NCT01630850 N/A
Recruiting
Islet Transplantation in Patients With "Brittle" Type I Diabetes
Condition
Diabetes Mellitus, Type 1
Enrollment
20 pts
Location
United States
Sponsor
University of Chicago
NCT02493478 N/A
Recruiting
Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs
Condition
Failed or Difficult Intubation, Sequela
Enrollment
150,000 pts
Location
United States, Australia, Austria
Sponsor
Children's Hospital of Philade
NCT06964685 N/A
Recruiting
Assessment of Support With Impella® Best Practices in Acute Myocardial Infarctio...
Condition
AMI Cardiogenic Shock
Enrollment
350 pts
Location
United States
Sponsor
Abiomed Inc.
NCT04959097 N/A
Recruiting
Retinoblastoma Patient Clinical Database and Tissue Repository
Condition
Retinoblastoma
Enrollment
800 pts
Location
United States, Canada
Sponsor
Children's Hospital Los Angele
NCT06177717 N/A
Recruiting
Deep Functional Phenotyping of the ALA Lung Health Cohort
Condition
Lung Diseases
Enrollment
1,000 pts
Location
United States
Sponsor
Johns Hopkins University
NCT05065216 Phase 2, Phase 3
Recruiting
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
Condition
Acute Stroke
Enrollment
728 pts
Location
United States, Belgium, Canada
Sponsor
DiaMedica Therapeutics Inc
NCT06438315 N/A
Recruiting
SuperSaturated Oxygen Comprehensive Observational Registry
Condition
STEMI - ST Elevation Myocardial Infarction
Enrollment
1,000 pts
Location
United States
Sponsor
TherOx
NCT06930625 Phase 3
Recruiting
A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acr...
Condition
Acromegaly
Enrollment
119 pts
Location
United States, Austria, Belgium
Sponsor
Debiopharm International SA
NCT07213804 Phase 3
Recruiting
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum...
Condition
Ovarian Neoplasms
Enrollment
1,630 pts
Location
United States, Australia, Austria
Sponsor
Eli Lilly and Company
NCT06635889 Phase 2
Recruiting
Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain
Condition
Nephrolithiasis
Enrollment
116 pts
Location
United States
Sponsor
University of Chicago
NCT04181138 N/A
Recruiting
Primary Sclerosing Cholangitis in Children
Condition
Primary Sclerosing Cholangitis
Enrollment
1,000 pts
Location
United States, Canada
Sponsor
Arbor Research Collaborative f
NCT05624125 N/A
Recruiting
BEETroot Juice to Reverse Functional Impairment in PAD
Condition
Peripheral Artery Disease
Enrollment
210 pts
Location
United States
Sponsor
Northwestern University
NCT06350097 Phase 3
Recruiting
Phase III, Open-label Study of First-line Osimertinib With or Without Datopotama...
Condition
Non-small Cell Lung Cancer
Enrollment
582 pts
Location
United States, Australia, Brazil
Sponsor
AstraZeneca
NCT06296186 N/A
Recruiting
Massed Prolonged Exposure for PTSD in Substance Use Treatment
Condition
Stress Disorders, Post-Traumatic
Enrollment
200 pts
Location
United States
Sponsor
Veterans Medical Research Foun
NCT05685303 N/A
Recruiting
Alleviant ALLAY-HF Study
Condition
Heart Failure
Enrollment
700 pts
Location
United States, Australia, Austria
Sponsor
Alleviant Medical, Inc.
NCT06925542 Phase 1
Recruiting
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory ...
Condition
SLE (Systemic Lupus)
Enrollment
80 pts
Location
United States, Germany, Spain
Sponsor
CRISPR Therapeutics
NCT07532603 Phase 2, Phase 3
Recruiting
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
Condition
Lichen Planopilaris
Enrollment
342 pts
Location
United States, Australia, Canada
Sponsor
Priovant Therapeutics, Inc.
NCT00470327 N/A
Recruiting
A Study of the Natural Progression of Interstitial Lung Disease (ILD)
Condition
Interstitial Lung Diseases
Enrollment
4,000 pts
Location
United States
Sponsor
University of Chicago
NCT04998396 Phase 1, Phase 2
Recruiting
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Cli...
Condition
Canavan Disease
Enrollment
26 pts
Location
United States
Sponsor
Aspa Therapeutics
NCT07203456 N/A
Recruiting
Testing Educational Modalities for Temporomandibular Disorders Curriculum
Condition
Confidence
Enrollment
90 pts
Location
United States
Sponsor
Midwestern University
NCT07901751 Phase 2, Phase 3
Recruiting
Study to Evaluate the Efficacy of a Single Intravitreal Injection of RTx-015 in ...
Condition
Retinitis Pigmentosa (RP)
Enrollment
60 pts
Location
United States
Sponsor
Ray Therapeutics, Inc.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology