State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 406 actively recruiting studies with Illinois sites out of 406 registered in total. The busiest research areas in Illinois are Ovarian Cancer, Breast Cancer, Prostate Cancer. Leading sponsors running trials in the state include University of Chicago, Northwestern University, National Cancer Institute (NCI). By stage, Illinois trials break down as Phase 1 (66), Phase 2 (130), Phase 3 (103), Phase 4 (13).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 406 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 406. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Ovarian Cancer, Breast Cancer, Prostate Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT06477172 N/A
Recruiting
Autologous Hair Follicle Derived Secretome as Adjunct to Aesthetic Procedures
Condition
Post Procedural Erythema
Enrollment
500 pts
Location
United States, Canada
Sponsor
Acorn Biolabs Inc.
NCT07030712 Phase 1
Recruiting
A Clinical Study of MK-8294 in Participants With Advanced Solid Tumors (MK-8294-...
Condition
Metastatic Neoplasm
Enrollment
67 pts
Location
United States, Israel, Netherlands
Sponsor
Merck Sharp & Dohme LLC
NCT04634383 N/A
Recruiting
A Phase I Feasibility Study of an Intracortical Visual Prosthesis (ICVP) for Peo...
Condition
Ocular Injury
Enrollment
5 pts
Location
United States
Sponsor
Illinois Institute of Technolo
NCT05907629 N/A
Recruiting
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vasc...
Condition
Stroke
Enrollment
300 pts
Location
United States
Sponsor
Yale University
NCT04889872 N/A
Recruiting
PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAV...
Condition
Aortic Stenosis, Calcific
Enrollment
2,250 pts
Location
United States, Australia, Canada
Sponsor
Edwards Lifesciences
NCT07389239 Phase 1, Phase 2
Recruiting
A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Adva...
Condition
Ovarian Cancer
Enrollment
24 pts
Location
United States
Sponsor
University of Chicago
NCT05125822 N/A
Recruiting
Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity
Condition
Childhood Obesity
Enrollment
260 pts
Location
United States
Sponsor
Ann & Robert H Lurie Children'
NCT04592445 N/A
Recruiting
Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having H...
Condition
Heart Failure With Preserved Ejection Fraction (HFpEF
Enrollment
150 pts
Location
United States, Georgia
Sponsor
Axon Therapies, Inc.
NCT07654361 Phase 3
Recruiting
Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight W...
Condition
Obesity
Enrollment
3,600 pts
Location
United States
Sponsor
Gasherbrum Bio, Inc., a wholly
NCT05902741 N/A
Recruiting
The Impact of a Race-Based Stress Reduction Intervention
Condition
Racism
Enrollment
300 pts
Location
United States
Sponsor
Loyola University
NCT05319353 Phase 3
Recruiting
A Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Antiviral...
Condition
Cytomegalovirus (CMV)
Enrollment
80 pts
Location
United States, Australia, Belgium
Sponsor
Takeda
NCT06001788 Phase 1
Recruiting
Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Ref...
Condition
AML
Enrollment
171 pts
Location
United States, Italy, Spain
Sponsor
Kura Oncology, Inc.
NCT05058651 Phase 2, Phase 3
Recruiting
Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemo...
Condition
Advanced Extrapulmonary Neuroendocrine Carcinoma
Enrollment
189 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT07266402 Phase 3
Recruiting
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus...
Condition
Chronic Inducible Urticaria
Enrollment
240 pts
Location
United States, Germany, Lithuania
Sponsor
Celldex Therapeutics
NCT05766670 Phase 3
Recruiting
Intramedullary Calcium Sulfate Antibiotic Depot
Condition
Open tíbia Fracture
Enrollment
242 pts
Location
United States
Sponsor
Wake Forest University Health
NCT05431088 Phase 2, Phase 3
Recruiting
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Condition
Sickle Cell Disease
Enrollment
389 pts
Location
United States, Brazil, India
Sponsor
Pfizer
NCT07784270 Phase 3
Recruiting
A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes...
Condition
Obesity or Overweight
Enrollment
1,500 pts
Location
United States, Argentina, Australia
Sponsor
AstraZeneca
NCT07464353 N/A
Recruiting
xDot Access Management System Early Feasibility Study
Condition
Vascular Closure Devices
Enrollment
30 pts
Location
United States
Sponsor
xDot Medical, Inc
NCT03193970 N/A
Recruiting
Measuring Surgical Recovery After Radical Cystectomy
Condition
Bladder Cancer
Enrollment
2,000 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
NCT07427017 Phase 2
Recruiting
Selenium Supplementation in Moderate-Severely Active Ulcerative Colitis Patients...
Condition
Ulcerative Colitis (UC)
Enrollment
180 pts
Location
United States
Sponsor
Northwestern University
NCT07013474 Phase 3
Recruiting
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 W...
Condition
COVID-19 Infection
Enrollment
300 pts
Location
United States, Argentina, Belgium
Sponsor
Pfizer
NCT05150691 Phase 1, Phase 2
Recruiting
A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
Condition
HER2-positive Advanced Solid Tumor
Enrollment
796 pts
Location
United States, Australia, China
Sponsor
DualityBio Inc.
NCT05667142 Phase 3
Recruiting
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-C...
Condition
Primary Generalized Tonic-Clonic Seizures
Enrollment
160 pts
Location
United States, Argentina, Australia
Sponsor
Xenon Pharmaceuticals Inc.
NCT05962359 N/A
Recruiting
Neural Prediction to Enhance Language
Condition
Bilateral Sensorineural Hearing Loss
Enrollment
700 pts
Location
United States
Sponsor
Ann & Robert H Lurie Children'
NCT07867080 Phase 3
Recruiting
A Phase 3 Trial for Intravitreal Injection of 4D-150 in Adults With Diabetic Mac...
Condition
Diabetic Macular Edema (DME)
Enrollment
514 pts
Location
United States, China, Japan
Sponsor
4D Molecular Therapeutics
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology