Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1
Trial Parameters
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Brief Summary
The purpose of this study is to evaluate the safety, tolerability, and efficacy of therapeutic vaccination with chimpanzee adenovirus ChAdOx1- and poxvirus modified vaccinia Ankara (MVA)-vectored conserved mosaic T-cell vaccines in a sequential regimen with the toll-like receptor 7 (TLR7) agonist vesatolimod (VES) and two broadly neutralizing antibodies (bNAbs) compared to placebo, to induce HIV-1 control during analytic treatment interruption (ATI).
Eligibility Criteria
Inclusion Criteria * Provision of written informed consent. * History of Initiation of combination ART within 90 days of acute HIV diagnosis * On ART for at least 12 months with no known ART interruption \>28 consecutive days within 12 months prior to Step 1 Study Entry * ART with an integrase inhibitor-based regimen with two NRTIs or dolutegravir/lamivudine regimen for at least 6 weeks prior to Study Entry. * Willingness to participate in the ATI and willingness to restart ART according to study guidelines. * Willingness to adhere to protocol therapy and complete all study visits. * Weight ≥50 kg and ≤150 kg at Screening. * CD4 cell count ≥500 cells/mm3 obtained within 60 days prior to Study Entry. * HIV-1 RNA \<50 copies/mL (or below the assay limit of quantification if local assay lower limit of quantification is \>50 copies/mL) for at least 1 year and within 60 days prior to Study Entry. * Select laboratory results within 60 days of study entry * For cisgender women and transgender