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Medical Condition
heart diseases
Total Trials
12
Recruiting Now
12
Trial Phases
Phase 3, Phase 4, Phase 2
Cardiovascular disease trials address coronary artery disease, heart failure, atrial fibrillation, and acute coronary syndromes — collectively the leading cause of mortality globally. After decades of incremental improvement in lipid-lowering and antithrombotic therapy, the field is now exploring RNA-based therapies, gene editing, and cardiac regeneration approaches.
Active research includes PCSK9 inhibitors and inclisiran for LDL reduction, SGLT2 inhibitors in heart failure with preserved ejection fraction (HFpEF), mavacamten for hypertrophic cardiomyopathy, cardiac stem cell therapies, and AI-guided device therapies. Wearables and remote monitoring are also being validated as clinical endpoints.
Enrollment eligibility typically depends on left ventricular ejection fraction (LVEF), NT-proBNP levels, and prior cardiovascular events.
Frequently Asked Questions — heart diseases Clinical Trials
How many clinical trials are currently recruiting for heart diseases?
ClinicalMetric currently tracks 12 actively recruiting clinical trials for heart diseases, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 12. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for heart diseases?
heart diseases research spans Phase 2 (1 trial), Phase 3 (1 trial), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a heart diseases clinical trial?
Eligibility criteria for heart diseases trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 2 1
Phase 3 1
Phase 4 1
Top Sponsors
1 trial
1 trial
1 trial
1 trial
1 trial
Recruiting Clinical Trials
NCT05550324
Recruiting
IPSC Repository of Pediatric Cardiovascular Disease
Enrollment
300 pts
Location
United States
Sponsor
Mingtao Zhao
NCT06587204
Recruiting
Understanding Decentralized Trial Engagement and Clinical Impediments Through Digital Efforts (UDECIDE) Among Unrepresented Groups With Poor Cardiovascular and Cardiometabolic Health
Enrollment
125 pts
Location
United States
Sponsor
University of Miami
NCT07087184
Recruiting
Gauging Outcomes of Total Milk Ingestion on Lipid and gControl
Enrollment
100 pts
Location
United States
Sponsor
University of California, San ...
NCT06400004 Phase 3
Recruiting
Lumason® Infusion vs. Bolus Administrations
Enrollment
106 pts
Location
United States
Sponsor
Bracco Diagnostics, Inc
NCT03217006
Recruiting
Randomization of Single vs Multiple Arterial Grafts
Enrollment
4,300 pts
Location
United States, Austr...
Sponsor
Weill Medical College of Corne...
NCT04407780
Recruiting
Cardio-Oncology Registry
Enrollment
5,000 pts
Location
France
Sponsor
European Georges Pompidou Hosp...
NCT06526195
Recruiting
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Enrollment
850 pts
Location
United States, Austr...
Sponsor
Abbott Medical Devices
NCT06467513 Phase 4
Recruiting
To Investigate the Effect of Esketamine Hydrochloride on Pulmonary Complications
Enrollment
102 pts
Location
China
Sponsor
Zhang XIao Mei
NCT07288216 Phase 2
Recruiting
Transition to KPL-387 Monotherapy Dosing & Administration Study
Enrollment
80 pts
Location
United States, Canad...
Sponsor
Kiniksa Pharmaceuticals Intern...
NCT05856318
Recruiting
Cardiometabolic Health in First Time Pregnancy
Enrollment
3,500 pts
Location
United Kingdom
Sponsor
Cambridge University Hospitals...
NCT06310031
Recruiting
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
Enrollment
780 pts
Location
United States
Sponsor
BrioHealth Solutions, Inc.
NCT04950218
Recruiting
Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis
Enrollment
1,000 pts
Location
Denmark
Sponsor
Herlev and Gentofte Hospital
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology