State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 406 actively recruiting studies with Illinois sites out of 406 registered in total. The busiest research areas in Illinois are Ovarian Cancer, Breast Cancer, Prostate Cancer. Leading sponsors running trials in the state include University of Chicago, Northwestern University, National Cancer Institute (NCI). By stage, Illinois trials break down as Phase 1 (66), Phase 2 (130), Phase 3 (103), Phase 4 (13).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 406 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 406. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Ovarian Cancer, Breast Cancer, Prostate Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT07100080 Phase 2, Phase 3
Recruiting
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy...
Condition
Non-Small Cell Lung Cancer
Enrollment
661 pts
Location
United States, Argentina, Belgium
Sponsor
Bristol-Myers Squibb
NCT06639503 Phase 1
Recruiting
Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau
Condition
Tibial Plateau Fractures
Enrollment
38 pts
Location
United States
Sponsor
University of Chicago
NCT05484973 N/A
Recruiting
Study to Assess the Ability of the Portable Scalp Cooling System (PSCS) to Preve...
Condition
Alopecia
Enrollment
99 pts
Location
United States
Sponsor
Cooler Heads Care Inc.
NCT07225023 N/A
Recruiting
A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy...
Condition
Dizziness
Enrollment
100 pts
Location
United States
Sponsor
Northwestern University
NCT06780670 Phase 2, Phase 3
Recruiting
Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Pr...
Condition
Prostate Cancer
Enrollment
443 pts
Location
United States, Australia, Brazil
Sponsor
Novartis Pharmaceuticals
NCT03435796 Phase 2, Phase 3
Recruiting
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
Condition
Neoplasms
Enrollment
1,541 pts
Location
United States, Australia, Austria
Sponsor
Celgene
NCT06223880 Phase 4
Recruiting
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing t...
Condition
Major Depressive Disorder
Enrollment
350 pts
Location
United States
Sponsor
Axsome Therapeutics, Inc.
NCT06554795 Phase 1, Phase 2
Recruiting
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
Condition
Solid Tumor, Adult
Enrollment
360 pts
Location
United States, Australia, China
Sponsor
DualityBio Inc.
NCT07143019 N/A
Recruiting
The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked ...
Condition
Hemorrhagic Stroke
Enrollment
214 pts
Location
United States
Sponsor
phenox Inc.
NCT07434492 Phase 2
Recruiting
Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy
Condition
Cerebral Palsy
Enrollment
60 pts
Location
United States
Sponsor
Shirley Ryan AbilityLab
NCT05864053 Phase 1, Phase 2
Recruiting
(2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain
Condition
Pain, Neuropathic
Enrollment
25 pts
Location
United States
Sponsor
Rush University Medical Center
NCT05680012 N/A
Recruiting
Tissue Destruction and Healing in Celiac Disease
Condition
Celiac Disease
Enrollment
220 pts
Location
United States
Sponsor
University of Chicago
NCT06834165 Phase 4
Recruiting
Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in ...
Condition
Allergic Reactions
Enrollment
600 pts
Location
United States
Sponsor
ARS Pharmaceuticals, Inc.
NCT04588922 Phase 1, Phase 2
Recruiting
Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Pa...
Condition
Hematologic Malignancies
Enrollment
160 pts
Location
United States, China
Sponsor
Sellas Life Sciences Group
NCT05691465 Phase 2
Recruiting
Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 1...
Condition
Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation
Enrollment
35 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT06632977 Phase 2
Recruiting
Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial
Condition
Castration-Resistant Prostate Carcinoma
Enrollment
474 pts
Location
United States
Sponsor
Alliance for Clinical Trials i
NCT05732831 Phase 1, Phase 2
Recruiting
Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors
Condition
Locally Advanced Solid Tumor
Enrollment
225 pts
Location
United States, France, Spain
Sponsor
Tango Therapeutics, Inc.
NCT06195072 Phase 2
Recruiting
Platform Clinical Study for Conquering Scleroderma
Condition
Interstitial Lung Disease Due to Systemic Disease
Enrollment
400 pts
Location
United States
Sponsor
Scleroderma Research Foundatio
NCT06423430 N/A
Recruiting
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Condition
Treatment Resistant Depression
Enrollment
100 pts
Location
United States
Sponsor
Abbott Medical Devices
NCT07224945 N/A
Recruiting
A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy
Condition
Low Back Pain
Enrollment
140 pts
Location
United States
Sponsor
Northwestern University
NCT07605429 Phase 3
Recruiting
BEACON - Phase III Clinical Study of Rugonersen in Angelman Syndrome.
Condition
Angelman Syndrome
Enrollment
165 pts
Location
United States, South Korea, Taiwan
Sponsor
OHB Pediatrics Ltd.
NCT07173751 Phase 3
Recruiting
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-N...
Condition
Breast Neoplasms
Enrollment
558 pts
Location
United States, Argentina, Australia
Sponsor
BioNTech SE
NCT07020312 Phase 2
Recruiting
Brain-Computer Interface Visualization Training to Optimize Muscle Activation Fo...
Condition
Anterior Cruciate Ligament Reconstruction
Enrollment
240 pts
Location
United States
Sponsor
Rush University Medical Center
NCT05131672 N/A
Recruiting
Cast or Operation for Medial Epicondyle Fracture Treatment in Children
Condition
Fracture Elbow
Enrollment
334 pts
Location
United States
Sponsor
Joseph Janicki
NCT05654922 Phase 3
Recruiting
Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progress...
Condition
Pre-Bronchiolitis Obliterans Syndrome
Enrollment
100 pts
Location
United States
Sponsor
Renovion, Inc.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology