Browse by Phase
Phase 2 Clinical Trials
Phase 2 trials study whether a drug works in people with a specific disease or condition. These studies enroll 100–300 participants and also continue to evaluate safety.
Total Trials
1,083
Recruiting Now
1,083
Top Conditions in Phase 2
Frequently Asked Questions — Phase 2 Trials
What does a Phase 2 clinical trial evaluate?
Phase 2 trials assess whether a drug or treatment works in people with a specific disease or condition. Enrolling 100–300 participants, these studies collect preliminary efficacy data while continuing to monitor safety and identify the optimal dosing regimen. A successful Phase 2 outcome is required to advance to large-scale Phase 3 testing.
How long do Phase 2 trials typically take?
Phase 2 clinical trials typically run for 1–4 years, depending on the condition, endpoint complexity, and enrollment rate. Rare disease trials or those with long-term outcome measures may run longer. Many sponsors run Phase 2 studies at multiple sites simultaneously to accelerate recruitment.
Who can participate in a Phase 2 clinical trial?
Eligibility for Phase 2 trials is defined by specific inclusion and exclusion criteria. Participants are typically patients diagnosed with the condition under study and may or may not have received prior treatment. Age, disease stage, comorbidities, and laboratory values are common eligibility factors. Review each trial's criteria on ClinicalTrials.gov for specific requirements.
Active Phase 2 Studies
NCT07061951 Phase 2
Recruiting
Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Rel...
Condition
Recurrent Chronic Lymphocytic Leukemia
Enrollment
20 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT06730373 Phase 2
Recruiting
First-line Treatment With RC48 Plus Sintilimab and S-1 in Advanced Gastric Cance...
Condition
HER2-positive Gastric Cancer
Enrollment
110 pts
Location
China
Sponsor
Qilu Hospital of Shandong Univ
NCT07407569 Phase 2
Recruiting
Developing a First-void Urine-based Infection Model to Study HPV-specific Antibo...
Condition
Human Papilloma Virus Infection Type 16
Enrollment
50 pts
Location
Belgium
Sponsor
Universiteit Antwerpen
NCT07118241 Phase 2
Recruiting
A PHASE II PROSPECTIVE RANDOMIZED DOUBLE-MASKED CONTROLLED STUDY ASSESSING THE S...
Condition
Sjögren's Syndrome
Enrollment
80 pts
Location
Australia
Sponsor
Lubris Bio Pty Ltd
NCT06915441 Phase 2
Recruiting
Lipid Infusions to Optimize Nutrition Trial
Condition
Bronchopulmonary Dysplasia
Enrollment
230 pts
Location
United States
Sponsor
The University of Texas Health
NCT07718672 Phase 2
Recruiting
Hotspot Stereotactic Ablative Radiotherapy Versus Traditional Stereotactic Ablat...
Condition
Early Stage Lung Non-Small Cell Carcinoma
Enrollment
200 pts
Location
United States
Sponsor
Roswell Park Cancer Institute
NCT07057596 Phase 2
Recruiting
Neoadjuvant Tebentafusp in Patients With Metastatic Uveal Melanoma
Condition
Mestastatic Uveal Melanoma
Enrollment
19 pts
Location
Germany, Spain
Sponsor
Grupo Español Multidisciplinar
NCT05882903 Phase 2
Recruiting
The Effect of Intra-sinus Application of Betamethasone Dipropionate Nasal Cream ...
Condition
Chronic Rhinosinusitis (Diagnosis)
Enrollment
24 pts
Location
Australia
Sponsor
Oticara Australia PTY LTD
NCT07402473 Phase 2
Recruiting
Optimize Neoadjuvant Therapy in HER2-Positive Early-Stage Breast Cancer
Condition
HER2-positive Early-stage Breast Cancer
Enrollment
50 pts
Location
United States
Sponsor
Rutgers, The State University
NCT04539951 Phase 2
Recruiting
Pragmatic Trial of Obsessive-compulsive Disorder
Condition
Obsessive-Compulsive Disorder
Enrollment
1,600 pts
Location
China
Sponsor
Shanghai Mental Health Center
NCT07694986 Phase 2
Recruiting
Trial of Therapies With IT cDC1s Combined w/ IT Trastuzamab for Her+ or IT Nivol...
Condition
Breast Cancer
Enrollment
30 pts
Location
United States
Sponsor
H. Lee Moffitt Cancer Center a
NCT06095505 Phase 2
Recruiting
A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer
Condition
Small Cell Lung Cancer
Enrollment
120 pts
Location
United States
Sponsor
Puma Biotechnology, Inc.
NCT07171905 Phase 2
Recruiting
CAT-VHL Exploring the Role of Carbonic Anhydrase IX as Diagnostic and Theranosti...
Condition
VHL - Von Hippel-Lindau Syndrome
Enrollment
38 pts
Location
Italy
Sponsor
IRCCS Ospedale San Raffaele
NCT06341595 Phase 2
Recruiting
Concurrent Chemoradiotherapy Combined With Sintilimab as Neoadjuvant Therapy for...
Condition
Gastric Cancer
Enrollment
40 pts
Location
China
Sponsor
The First Affiliated Hospital
NCT07300969 Phase 2
Recruiting
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
Condition
Major Depressive Disorder (MDD)
Enrollment
300 pts
Location
United States, Bulgaria, Czechia
Sponsor
Draig Therapeutics Ltd
NCT06194305 Phase 2
Recruiting
Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervent...
Condition
Tourette Syndrome
Enrollment
100 pts
Location
United States
Sponsor
University of Minnesota
NCT07595705 Phase 2
Recruiting
Gingival Hyperpigmentation Treatment
Condition
Gingival Pigmentation
Enrollment
30 pts
Location
Egypt
Sponsor
Cairo University
NCT05190094 Phase 2
Recruiting
Prediction of Treatment Efficacy of the Combination of Palbociclib/(Letrozole or...
Condition
Hormonal Receptors Positive, HER2 Negative, Advanced Breast Cancer
Enrollment
80 pts
Location
Algeria, Jordan, Saudi Arabia
Sponsor
International Cancer Research
NCT07458529 Phase 2
Recruiting
Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMM...
Condition
Rectal Cancer, Adenocarcinoma
Enrollment
50 pts
Location
China
Sponsor
Seventh Medical Center of PLA
NCT06381453 Phase 2
Recruiting
Belimumab in Autoimmune Hepatitis
Condition
Autoimmune Hepatitis
Enrollment
48 pts
Location
Canada
Sponsor
University Health Network, Tor
NCT07751341 Phase 2
Recruiting
A Clinical Study of SHR-9839 as Monotherapy or in Combination With Chemotherapy ...
Condition
Advanced Esophageal Squamous Cell Carcinoma
Enrollment
84 pts
Location
China
Sponsor
Suzhou Suncadia Biopharmaceuti
NCT06928766 Phase 2
Recruiting
Effects of Eszopiclone and Lemborexant in People With OSA With a Low Arousal Thr...
Condition
OSA - Obstructive Sleep Apnea
Enrollment
15 pts
Location
Australia
Sponsor
Flinders University
NCT07082686 Phase 2
Recruiting
A Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed...
Condition
Relapsed or Refractory Mantle Cell Lymphoma (MCL)
Enrollment
75 pts
Location
China
Sponsor
Beijing InnoCare Pharma Tech C
NCT07549841 Phase 2
Recruiting
Exploratory Study Evaluating the Relevance of [68Ga]Ga-FAPI-46 for Staging and I...
Condition
Transthyretin Cardiac Amyloidosis
Enrollment
40 pts
Location
France
Sponsor
Nantes University Hospital
NCT07539805 Phase 2
Recruiting
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adole...
Condition
Major Depressive Disorder (MDD)
Enrollment
60 pts
Location
China
Sponsor
First Affiliated Hospital of C
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology