Browse by Phase
Phase 2 Clinical Trials
Phase 2 trials study whether a drug works in people with a specific disease or condition. These studies enroll 100–300 participants and also continue to evaluate safety.
Total Trials
1,078
Recruiting Now
1,078
Top Conditions in Phase 2
Frequently Asked Questions — Phase 2 Trials
What does a Phase 2 clinical trial evaluate?
Phase 2 trials assess whether a drug or treatment works in people with a specific disease or condition. Enrolling 100–300 participants, these studies collect preliminary efficacy data while continuing to monitor safety and identify the optimal dosing regimen. A successful Phase 2 outcome is required to advance to large-scale Phase 3 testing.
How long do Phase 2 trials typically take?
Phase 2 clinical trials typically run for 1–4 years, depending on the condition, endpoint complexity, and enrollment rate. Rare disease trials or those with long-term outcome measures may run longer. Many sponsors run Phase 2 studies at multiple sites simultaneously to accelerate recruitment.
Who can participate in a Phase 2 clinical trial?
Eligibility for Phase 2 trials is defined by specific inclusion and exclusion criteria. Participants are typically patients diagnosed with the condition under study and may or may not have received prior treatment. Age, disease stage, comorbidities, and laboratory values are common eligibility factors. Review each trial's criteria on ClinicalTrials.gov for specific requirements.
Active Phase 2 Studies
NCT05715229 Phase 2
Recruiting
Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Tr...
Condition
Carcinoma, Non-Small-Cell Lung
Enrollment
108 pts
Location
United States
Sponsor
Hackensack Meridian Health
NCT07300969 Phase 2
Recruiting
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
Condition
Major Depressive Disorder (MDD)
Enrollment
300 pts
Location
United States, Bulgaria, Czechia
Sponsor
Draig Therapeutics Ltd
NCT07617272 Phase 2
Recruiting
Prostate Androgen Response Investigation Using a Stratification BIOmarker; Predi...
Condition
Prostate Cancer (Adenocarcinoma)
Enrollment
100 pts
Location
Sweden
Sponsor
Region Stockholm
NCT07433673 Phase 2
Recruiting
Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced...
Condition
Colon and Rectal Cancer
Enrollment
20 pts
Location
United States
Sponsor
Columbia University
NCT07205731 Phase 2
Recruiting
Phase II Study Evaluating Safety and Efficacy of Tislelizumab for Elderly Patien...
Condition
Esophageal Squamous Cell Carcinoma (ESCC)
Enrollment
95 pts
Location
France
Sponsor
University Hospital, Clermont-
NCT07215702 Phase 2
Recruiting
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Parti...
Condition
Sepsis
Enrollment
124 pts
Location
United States, Argentina, Belgium
Sponsor
AstraZeneca
NCT07311577 Phase 2
Recruiting
Disitamab Vedotin Combined With Platinum and Bevacizumab as First-Line and Maint...
Condition
Ovarian Cancer Metastatic
Enrollment
43 pts
Location
China
Sponsor
Jiangsu Cancer Institute & Hos
NCT07645157 Phase 2
Recruiting
Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression
Condition
Major Depressive Disorder (MDD)
Enrollment
120 pts
Location
China
Sponsor
First Affiliated Hospital of C
NCT06088381 Phase 2
Recruiting
Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Ci...
Condition
Head and Neck Cancer
Enrollment
61 pts
Location
United States
Sponsor
University of Maryland, Baltim
NCT07420530 Phase 2
Recruiting
Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Mo...
Condition
Exercise-Induced Vocal Cord Dysfunction
Enrollment
130 pts
Location
United States
Sponsor
Indiana University
NCT07216430 Phase 2
Recruiting
Safety and Efficacy of wSp Vaccine in Young Children
Condition
Acute Otitis Media (AOM)
Enrollment
320 pts
Location
United States
Sponsor
Serum Life Science Europe GmbH
NCT04901936 Phase 2
Recruiting
A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglo...
Condition
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Enrollment
12 pts
Location
United States, Czechia, France
Sponsor
Apellis Pharmaceuticals, Inc.
NCT07207395 Phase 2
Recruiting
A Study of Orally Administered JBI-802 Alone or in Combination With Pembrolizuma...
Condition
Lung Cancer (NSCLC)
Enrollment
30 pts
Location
United States
Sponsor
The Christ Hospital
NCT06458439 Phase 2
Recruiting
Epcoritamab-CAR T Cells for Large B-cell Lymphomas
Condition
Lymphoma, Non-Hodgkin
Enrollment
31 pts
Location
United States
Sponsor
Abramson Cancer Center at Penn
NCT05687357 Phase 2
Recruiting
Tislelizumab in Combination With Pre-operative CRT Versus SOC for Locally Advanc...
Condition
Gastric Cancer
Enrollment
140 pts
Location
China
Sponsor
The Affiliated Nanjing Drum To
NCT06809634 Phase 2
Recruiting
Large Linguistic Model for Clinical Reaoning of Physical Therapy Students
Condition
Healthy
Enrollment
60 pts
Location
Spain
Sponsor
Neuron, Spain
NCT04317534 Phase 2
Recruiting
Adjuvant Pembrolizumab vs Observation Following Curative Resection for Stage I N...
Condition
NSCLC, Stage I
Enrollment
244 pts
Location
United States
Sponsor
Greg Durm, MD
NCT06410599 Phase 2
Recruiting
Pharmacologic Treatment Augmentation in Chronic Depression
Condition
Major Depressive Disorder
Enrollment
60 pts
Location
Germany
Sponsor
University Hospital Tuebingen
NCT00018057 Phase 2
Recruiting
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Condition
Anxiety Disorders
Enrollment
3,500 pts
Location
United States
Sponsor
National Institute of Mental H
NCT05698212 Phase 2
Recruiting
Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometrio...
Condition
Endometriosis
Enrollment
75 pts
Location
United States
Sponsor
Hera Biotech, Inc.
NCT02310867 Phase 2
Recruiting
Immunomodulation to Optimize Vascularized Composite Allograft Integration for Li...
Condition
Immunosuppression
Enrollment
50 pts
Location
United States
Sponsor
Linda Cendales
NCT05933239 Phase 2
Recruiting
Macrophage Imaging Using Ga-MMR-VHH2 in Lung Cancer Patients
Condition
Non-small Cell Lung Cancer
Enrollment
20 pts
Location
Belgium
Sponsor
Universitair Ziekenhuis Brusse
NCT06088030 Phase 2
Recruiting
Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Ped...
Condition
Pediatric Cancer
Enrollment
50 pts
Location
China
Sponsor
Yang Li
NCT07810530 Phase 2
Recruiting
Study of a Copaiba-Based Mouthwash Combined With Low-Level Laser Therapy in the ...
Condition
Oral Mucositis
Enrollment
76 pts
Location
Brazil
Sponsor
Instituto Nacional de Cancer,
NCT06207799 Phase 2
Recruiting
Pre-transplant Purging and Post-transplant MRD-guided Maintenance Therapy With E...
Condition
Multiple Myeloma
Enrollment
40 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology