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Clinical Trials in Tennessee

Tennessee is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Tennessee and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.

Right now ClinicalMetric tracks 332 actively recruiting studies with Tennessee sites out of 332 registered in total. The busiest research areas in Tennessee are Solid Tumor, Breast Cancer, Acute Myeloid Leukemia. Leading sponsors running trials in the state include Vanderbilt University Medical Center, Merck Sharp & Dohme LLC, National Cancer Institute (NCI). By stage, Tennessee trials break down as Phase 1 (80), Phase 2 (113), Phase 3 (92), Phase 4 (14).

All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.

Total Trials
332
Recruiting Now
332
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Top Conditions in Tennessee
Solid Tumor (9)Breast Cancer (8)Acute Myeloid Leukemia (7)Ovarian Cancer (7)Endometrial Cancer (6)Advanced Solid Tumor (6)Metastatic Breast Cancer (6)Pancreatic Cancer (5)Obesity (5)Solid Tumor, Adult (5)Advanced Solid Tumors (5)Multiple Myeloma (5)

Frequently Asked Questions — Clinical Trials in Tennessee

How many clinical trials are currently recruiting in Tennessee?
ClinicalMetric currently tracks 332 actively recruiting clinical trials with at least one location in Tennessee. The total number of registered studies—including active but not currently enrolling trials—is 332. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Tennessee?
Tennessee hosts clinical trials across a broad range of medical conditions, including Solid Tumor, Breast Cancer, Acute Myeloid Leukemia, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Tennessee serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Tennessee?
To join a clinical trial in Tennessee, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Tennessee maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.

Recruiting Trials in Tennessee

NCT03959085 Phase 3
Recruiting
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With ...
Condition
B Acute Lymphoblastic Leukemia
Enrollment
5,951 pts
Location
United States, Australia, Canada
Sponsor
Children's Oncology Group
View Trial →
NCT06398418 Phase 1
Recruiting
R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on ...
Condition
Solid Tumor, Adult
Enrollment
33 pts
Location
United States
Sponsor
Rise Therapeutics LLC
View Trial →
NCT07609108 Phase 3
Recruiting
Pridopidine Phase 3 Study in Huntington's Disease
Condition
Huntington Disease
Enrollment
400 pts
Location
United States, Belgium, Canada
Sponsor
Prilenia
View Trial →
NCT06941389 N/A
Recruiting
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Tra...
Condition
Sickle Cell Disease (SCD)
Enrollment
480 pts
Location
United States, Canada
Sponsor
University of Rochester
View Trial →
NCT06506461 Phase 1
Recruiting
Gene Editing For Sickle Cell Disease
Condition
Sickle Cell Disease
Enrollment
25 pts
Location
United States
Sponsor
St. Jude Children's Research H
View Trial →
NCT06841354 Phase 3
Recruiting
A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Comb...
Condition
Triple Negative Breast Neoplasms
Enrollment
1,000 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
View Trial →
NCT07684235 Phase 3
Recruiting
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of ...
Condition
Obesity
Enrollment
3,200 pts
Location
United States, Australia, Canada
Sponsor
Amgen
View Trial →
NCT06952803 Phase 3
Recruiting
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standar...
Condition
Prostate Cancer
Enrollment
700 pts
Location
United States, Argentina, Australia
Sponsor
AstraZeneca
View Trial →
NCT05908331 N/A
Recruiting
MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions
Condition
In-Stent Restenosis
Enrollment
492 pts
Location
United States
Sponsor
Concept Medical Inc.
View Trial →
NCT06499805 N/A
Recruiting
Barriers and Facilitators to OTC Hearing Aids Success
Condition
Hearing Loss, Sensorineural
Enrollment
360 pts
Location
United States
Sponsor
Yu-Hsiang Wu
View Trial →
NCT06662786 Phase 3
Recruiting
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or ...
Condition
Colorectal Neoplasms
Enrollment
1,000 pts
Location
United States, Belgium, Brazil
Sponsor
Janssen Research & Development
View Trial →
NCT06623422 Phase 3
Recruiting
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in...
Condition
Carcinoma, Non-Small-Cell Lung
Enrollment
680 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
View Trial →
NCT06535854 N/A
Recruiting
Prevail Global Study
Condition
Coronary Artery Disease
Enrollment
1,205 pts
Location
United States, Canada, Germany
Sponsor
Medtronic Vascular
View Trial →
NCT06321302 Phase 2
Recruiting
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diab...
Condition
Diabetic Retinopathy
Enrollment
175 pts
Location
United States, Germany, Hungary
Sponsor
Boehringer Ingelheim
View Trial →
NCT05366881 N/A
Recruiting
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and ...
Condition
Brain Cancer
Enrollment
7,000 pts
Location
United States
Sponsor
Adela, Inc
View Trial →
NCT05501665 Phase 1, Phase 2
Recruiting
Split Course Adaptive Radiation Therapy With Pembrolizumab With/Without Chemothe...
Condition
Lung Non-Small Cell Carcinoma
Enrollment
25 pts
Location
United States
Sponsor
Vanderbilt-Ingram Cancer Cente
View Trial →
NCT06738407 Phase 4
Recruiting
Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
Condition
Gonorrhea
Enrollment
760 pts
Location
United States
Sponsor
Westat
View Trial →
NCT02074839 Phase 1
Recruiting
Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malign...
Condition
Relapsed or Refractory Acute Myeloid Leukemia (AML)
Enrollment
291 pts
Location
United States, France
Sponsor
Institut de Recherches Interna
View Trial →
NCT07775495 N/A
Recruiting
Observational Study of Decentralized Urine Optical Interaction Patterns Associat...
Condition
Healthy Adult Participants
Enrollment
15 pts
Location
United States
Sponsor
Ecotera Health LLC
View Trial →
NCT07382167 Phase 3
Recruiting
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopa...
Condition
Chronic Idiopathic Constipation (CIC)
Enrollment
692 pts
Location
United States
Sponsor
Ardelyx
View Trial →
NCT06797336 Phase 1
Recruiting
A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors
Condition
Solid Tumor
Enrollment
300 pts
Location
United States, South Korea
Sponsor
PAQ Therapeutics, Inc.
View Trial →
NCT06971939 Phase 4
Recruiting
Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Includi...
Condition
Macular Telangiectasia Type 2 (MacTel)
Enrollment
234 pts
Location
United States, Australia
Sponsor
Neurotech Pharmaceuticals
View Trial →
NCT07106762 Phase 2, Phase 3
Recruiting
Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Me...
Condition
Urothelial Cancer
Enrollment
470 pts
Location
United States, Argentina, Australia
Sponsor
Bristol-Myers Squibb
View Trial →
NCT05920356 Phase 3
Recruiting
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab P...
Condition
Non-Small Cell Lung Cancer (NSCLC)
Enrollment
750 pts
Location
United States, Argentina, Australia
Sponsor
Amgen
View Trial →
NCT06548542 Phase 2
Recruiting
Study of Targeted Therapies for the Treatment of Adult Participants With Moderat...
Condition
Crohn's Disease
Enrollment
590 pts
Location
United States, Austria, Belgium
Sponsor
AbbVie
View Trial →
Page 13 of 14 — 332 trials total
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology