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Clinical Trials in Tennessee

Tennessee is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Tennessee and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.

Right now ClinicalMetric tracks 332 actively recruiting studies with Tennessee sites out of 332 registered in total. The busiest research areas in Tennessee are Solid Tumor, Breast Cancer, Acute Myeloid Leukemia. Leading sponsors running trials in the state include Vanderbilt University Medical Center, Merck Sharp & Dohme LLC, National Cancer Institute (NCI). By stage, Tennessee trials break down as Phase 1 (80), Phase 2 (113), Phase 3 (92), Phase 4 (14).

All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.

Total Trials
332
Recruiting Now
332
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Top Conditions in Tennessee
Solid Tumor (9)Breast Cancer (8)Acute Myeloid Leukemia (7)Ovarian Cancer (7)Endometrial Cancer (6)Advanced Solid Tumor (6)Metastatic Breast Cancer (6)Pancreatic Cancer (5)Obesity (5)Solid Tumor, Adult (5)Advanced Solid Tumors (5)Multiple Myeloma (5)

Frequently Asked Questions — Clinical Trials in Tennessee

How many clinical trials are currently recruiting in Tennessee?
ClinicalMetric currently tracks 332 actively recruiting clinical trials with at least one location in Tennessee. The total number of registered studies—including active but not currently enrolling trials—is 332. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Tennessee?
Tennessee hosts clinical trials across a broad range of medical conditions, including Solid Tumor, Breast Cancer, Acute Myeloid Leukemia, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Tennessee serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Tennessee?
To join a clinical trial in Tennessee, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Tennessee maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.

Recruiting Trials in Tennessee

NCT06532006 Phase 3
Recruiting
A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemothera...
Condition
Gastroesophageal-junction Cancer
Enrollment
550 pts
Location
United States, Argentina, Australia
Sponsor
Shanghai Henlius Biotech
View Trial →
NCT07737743 Phase 2
Recruiting
A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in ...
Condition
Sjögren's Disease
Enrollment
344 pts
Location
United States, Australia, Canada
Sponsor
Novartis Pharmaceuticals
View Trial →
NCT05455619 Phase 1, Phase 2
Recruiting
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K A...
Condition
HR+/HER2-negative Breast Cancer
Enrollment
52 pts
Location
United States
Sponsor
SynDevRx, Inc.
View Trial →
NCT07409207 N/A
Recruiting
Neurophysiology of Reward Signaling in Parkinson's Disease
Condition
Parkinson Disease
Enrollment
75 pts
Location
United States
Sponsor
Vanderbilt University Medical
View Trial →
NCT06330064 Phase 1, Phase 2
Recruiting
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in ...
Condition
Recurrent or Metastatic Solid Tumors
Enrollment
680 pts
Location
United States, Argentina, Australia
Sponsor
Daiichi Sankyo
View Trial →
NCT07518186 Phase 3
Recruiting
A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or ...
Condition
Multiple Myeloma
Enrollment
700 pts
Location
United States, Australia, Brazil
Sponsor
Janssen Research & Development
View Trial →
NCT05234567 N/A
Recruiting
A Prospective Sub-Study of the Global Hypophosphatasia Registry
Condition
Hypophosphatasia
Enrollment
30 pts
Location
United States
Sponsor
Alexion Pharmaceuticals, Inc.
View Trial →
NCT05799144 Phase 2
Recruiting
pBI-11 & TA-HPV (With Pembrolizumab as Treatment for Patients w/Advanced, PD-L1 ...
Condition
Metastatic Oropharyngeal Carcinoma
Enrollment
54 pts
Location
United States
Sponsor
Michael K. Gibson
View Trial →
NCT07514819 N/A
Recruiting
Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's L...
Condition
Pediatric Solid Tumors
Enrollment
100 pts
Location
United States
Sponsor
St. Jude Children's Research H
View Trial →
NCT05898399 Phase 1, Phase 2
Recruiting
Study of ART6043 in Advanced/Metastatic Solid Tumors Patients (POLKA)
Condition
Advanced Solid Tumor
Enrollment
181 pts
Location
United States, Spain, United Kingdom
Sponsor
Artios Pharma Ltd
View Trial →
NCT05029999 Phase 1
Recruiting
CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer
Condition
HER2-negative Breast Cancer
Enrollment
30 pts
Location
United States
Sponsor
University of Texas Southweste
View Trial →
NCT07090499 Phase 1
Recruiting
A Study to Learn About the Study Medicine Called PF-08046876 in People With Adva...
Condition
Advanced/Metastatic Solid Tumors
Enrollment
540 pts
Location
United States, Canada, China
Sponsor
Pfizer
View Trial →
NCT06476132 Phase 2
Recruiting
Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung...
Condition
Lung Transplant
Enrollment
234 pts
Location
United States, Canada
Sponsor
National Institute of Allergy
View Trial →
NCT06741436 N/A
Recruiting
Exercise Testing After Preeclampsia
Condition
Preeclampsia
Enrollment
500 pts
Location
United States
Sponsor
Vanderbilt University Medical
View Trial →
NCT06603844 Phase 1, Phase 2
Recruiting
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
Condition
Solid Tumor
Enrollment
156 pts
Location
United States, United Kingdom
Sponsor
Corbus Pharmaceuticals Inc.
View Trial →
NCT06479135 Phase 3
Recruiting
Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With ...
Condition
Myelofibrosis
Enrollment
600 pts
Location
United States, Australia, Austria
Sponsor
Kartos Therapeutics, Inc.
View Trial →
NCT06317649 Phase 2
Recruiting
Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute M...
Condition
Acute Myeloid Leukemia
Enrollment
147 pts
Location
United States, Canada, Puerto Rico
Sponsor
National Cancer Institute (NCI
View Trial →
NCT05573126 Phase 1, Phase 2
Recruiting
Phase 1/2 Study to Evaluate EP0062 as Monotherapy and in Combination in Patients...
Condition
Hormone Receptor-positive Breast Cancer
Enrollment
95 pts
Location
United States, Spain, United Kingdom
Sponsor
Ellipses Pharma
View Trial →
NCT05194397 Phase 2
Recruiting
Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Sur...
Condition
Lymphoblastic Leukemia
Enrollment
80 pts
Location
United States
Sponsor
Children's Hospital of Philade
View Trial →
NCT05139017 Phase 2, Phase 3
Recruiting
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care i...
Condition
DLBCL
Enrollment
290 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
View Trial →
NCT07154290 Phase 2
Recruiting
A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adul...
Condition
Non Small Cell Lung Cancer
Enrollment
300 pts
Location
United States
Sponsor
Regeneron Pharmaceuticals
View Trial →
NCT05886920 Phase 1, Phase 2
Recruiting
A Phase 1/2 Study of D3S-002 as Monotherapy or Combination Therapy in Adult Subj...
Condition
Advanced Solid Tumors With MAPK Pathway Mutations
Enrollment
67 pts
Location
United States, Australia, China
Sponsor
D3 Bio (Wuxi) Co., Ltd
View Trial →
NCT06615050 Phase 3
Recruiting
A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosp...
Condition
Graft-versus-host Disease (GVHD)
Enrollment
572 pts
Location
United States
Sponsor
Incyte Corporation
View Trial →
NCT05172960 N/A
Recruiting
ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve
Condition
Aortic Stenosis, Severe
Enrollment
1,234 pts
Location
United States, Australia, Canada
Sponsor
Edwards Lifesciences
View Trial →
NCT07654374 Phase 3
Recruiting
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes...
Condition
Obesity
Enrollment
1,100 pts
Location
United States
Sponsor
Gasherbrum Bio, Inc., a wholly
View Trial →
Page 12 of 14 — 332 trials total
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology