State NC
Clinical Trials in North Carolina
North Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in North Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 420 actively recruiting studies with North Carolina sites out of 420 registered in total. The busiest research areas in North Carolina are Breast Cancer, Acute Myeloid Leukemia, Cancer. Leading sponsors running trials in the state include Duke University, Wake Forest University Health Sciences, National Cancer Institute (NCI). By stage, North Carolina trials break down as Phase 1 (67), Phase 2 (115), Phase 3 (110), Phase 4 (20).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in North Carolina
Frequently Asked Questions — Clinical Trials in North Carolina
How many clinical trials are currently recruiting in North Carolina?
ClinicalMetric currently tracks 420 actively recruiting clinical trials with at least one location in North Carolina. The total number of registered studies—including active but not currently enrolling trials—is 420. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in North Carolina?
North Carolina hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Acute Myeloid Leukemia, Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout North Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in North Carolina?
To join a clinical trial in North Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in North Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in North Carolina
NCT06495190 N/A
Recruiting
Cognition, Flavonoids, Exercise, Gut Microbiome
Condition
Cognitive Decline, Mild
Enrollment
240 pts
Location
United States
Sponsor
Appalachian State University
NCT06126276 Phase 2
Recruiting
Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Tar...
Condition
Malignant Female Reproductive System Neoplasm
Enrollment
70 pts
Location
United States, Puerto Rico
Sponsor
National Cancer Institute (NCI
NCT04256317 Phase 2, Phase 3
Recruiting
A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplas...
Condition
Myelodysplastic Syndromes
Enrollment
316 pts
Location
United States, Canada, Czechia
Sponsor
Taiho Oncology, Inc.
NCT06979362 Phase 2
Recruiting
A Research Study Comparing Different Doses of CDR132L With Placebo on the Struct...
Condition
Heart Failure
Enrollment
200 pts
Location
United States, Canada, Germany
Sponsor
Novo Nordisk A/S
NCT06816927 Phase 2
Recruiting
Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab
Condition
Newly Diagnosed Glioblastoma
Enrollment
92 pts
Location
United States, Australia
Sponsor
Duke University
NCT07811362 N/A
Recruiting
CRPS-RISE Outcomes Registry
Condition
Complex Regional Pain Syndrome I (CRPS I)
Enrollment
270 pts
Location
United States
Sponsor
Ambros Therapeutics, Inc.
NCT04613596 Phase 2, Phase 3
Recruiting
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and...
Condition
Advanced Non-Small Cell Lung Cancer
Enrollment
626 pts
Location
United States, Argentina, Australia
Sponsor
Mirati Therapeutics Inc.
NCT07638462 N/A
Recruiting
RIsE Stroke Mobility Study
Condition
Acute Ischemic Stroke
Enrollment
50 pts
Location
United States
Sponsor
Wake Forest University Health
NCT06672146 Phase 2
Recruiting
Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia ...
Condition
Acute Myeloid Leukemia
Enrollment
93 pts
Location
United States, Puerto Rico
Sponsor
National Cancer Institute (NCI
NCT06963827 Phase 3
Recruiting
A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy
Condition
Kidney Disease
Enrollment
347 pts
Location
United States, Argentina, Australia
Sponsor
Takeda
NCT05721859 N/A
Recruiting
M-Vizion™ Macroscopic Radiographic Study
Condition
Revision Hip Arthroplasty
Enrollment
70 pts
Location
United States
Sponsor
Medacta USA
NCT06445946 Phase 4
Recruiting
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Tr...
Condition
Gestational Diabetes Mellitus
Enrollment
1,572 pts
Location
United States
Sponsor
Ohio State University
NCT07218380 Phase 3
Recruiting
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary T...
Condition
Carcinoma, Transitional Cell
Enrollment
450 pts
Location
United States, Australia, Brazil
Sponsor
Eli Lilly and Company
NCT05611242 Phase 3
Recruiting
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlu...
Condition
Acute Ischemic Stroke
Enrollment
404 pts
Location
United States
Sponsor
Mercy Health Ohio
NCT02418442 N/A
Recruiting
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
Condition
Rheumatic Joint Disease
Enrollment
20,000 pts
Location
United States, Canada, Israel
Sponsor
Duke University
NCT06907173 Phase 3
Recruiting
Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESE...
Condition
Status Epilepticus
Enrollment
770 pts
Location
United States
Sponsor
University of Virginia
NCT04322318 Phase 2
Recruiting
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and R...
Condition
Anaplastic Kidney Wilms Tumor
Enrollment
256 pts
Location
United States, Australia, Canada
Sponsor
Children's Oncology Group
NCT06552286 N/A
Recruiting
STRW-T Intervention for Autistic Adolescents in 11th and 12th Grade
Condition
Autism Spectrum Disorder
Enrollment
192 pts
Location
United States
Sponsor
Children's Hospital Medical Ce
NCT04861818 N/A
Recruiting
The Role of the Time of Day in the Effects of Exercise on Memory in Heathy Young...
Condition
Aerobic Exercise
Enrollment
80 pts
Location
United States
Sponsor
University of North Carolina,
NCT03435796 Phase 2, Phase 3
Recruiting
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
Condition
Neoplasms
Enrollment
1,541 pts
Location
United States, Australia, Austria
Sponsor
Celgene
NCT06223880 Phase 4
Recruiting
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing t...
Condition
Major Depressive Disorder
Enrollment
350 pts
Location
United States
Sponsor
Axsome Therapeutics, Inc.
NCT06554795 Phase 1, Phase 2
Recruiting
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
Condition
Solid Tumor, Adult
Enrollment
360 pts
Location
United States, Australia, China
Sponsor
DualityBio Inc.
NCT07143019 N/A
Recruiting
The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked ...
Condition
Hemorrhagic Stroke
Enrollment
214 pts
Location
United States
Sponsor
phenox Inc.
NCT07060807 Phase 3
Recruiting
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
Condition
Breast Neoplasms
Enrollment
1,000 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
NCT07702539 N/A
Recruiting
NASA Exercise Prebreathe Study
Condition
Decompression Sickness
Enrollment
30 pts
Location
United States
Sponsor
Duke University
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology