State NC
Clinical Trials in North Carolina
North Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in North Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 394 actively recruiting studies with North Carolina sites out of 394 registered in total. The busiest research areas in North Carolina are Breast Cancer, Prostate Cancer, Acute Myeloid Leukemia. Leading sponsors running trials in the state include Duke University, Wake Forest University Health Sciences, University of North Carolina, Chapel Hill. By stage, North Carolina trials break down as Phase 1 (57), Phase 2 (102), Phase 3 (85), Phase 4 (15).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in North Carolina
Frequently Asked Questions — Clinical Trials in North Carolina
How many clinical trials are currently recruiting in North Carolina?
ClinicalMetric currently tracks 394 actively recruiting clinical trials with at least one location in North Carolina. The total number of registered studies—including active but not currently enrolling trials—is 394. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in North Carolina?
North Carolina hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Prostate Cancer, Acute Myeloid Leukemia, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout North Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in North Carolina?
To join a clinical trial in North Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in North Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in North Carolina
NCT07453069 Phase 2
Recruiting
Effect of FB301 on Vaginal Bacterial Profile in Women With Asymptomatic Vaginal ...
Condition
Vaginal Dysbiosis
Enrollment
30 pts
Location
United States
Sponsor
Freya Biosciences ApS
NCT06511141 N/A
Recruiting
Sacral Neuromodulation for Male Overactive Bladder (MOAB)
Condition
Overactive Bladder
Enrollment
150 pts
Location
United States
Sponsor
Axonics, Inc.
NCT05828823 N/A
Recruiting
Incremental Hemodialysis: The TwoPlus Trial
Condition
End-Stage Kidney Disease
Enrollment
350 pts
Location
United States
Sponsor
Wake Forest University Health
NCT06864403 Phase 4
Recruiting
Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch
Condition
Pouchitis
Enrollment
25 pts
Location
United States
Sponsor
University of North Carolina,
NCT07290790 N/A
Recruiting
A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the ...
Condition
Malocclusion
Enrollment
90 pts
Location
United States, Spain, United Kingdom
Sponsor
Dentsply Sirona Implants and C
NCT07121582 N/A
Recruiting
Modulation of Brain Rhythms in Stroke
Condition
Stroke
Enrollment
20 pts
Location
United States
Sponsor
University of North Carolina,
NCT04802759 Phase 1, Phase 2
Recruiting
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in...
Condition
Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer
Enrollment
316 pts
Location
United States, Australia, Israel
Sponsor
Hoffmann-La Roche
NCT06498635 Phase 3
Recruiting
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After ...
Condition
Lung Non-Small Cell Carcinoma
Enrollment
306 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT06259292 N/A
Recruiting
Comprehensive HHT Outcomes Registry of the United States (CHORUS)
Condition
Hereditary Hemorrhagic Telangiectasia
Enrollment
10,000 pts
Location
United States
Sponsor
Cure HHT
NCT05939700 N/A
Recruiting
Mavacamten Pregnancy Surveillance Program
Condition
Breastfeeding
Enrollment
20 pts
Location
United States
Sponsor
Bristol-Myers Squibb
NCT06527287 N/A
Recruiting
Neurocognitive Ankle Training for Instability to Optimize Neuromusculoskeletal O...
Condition
Chronic Ankle Instability
Enrollment
180 pts
Location
United States
Sponsor
Womack Army Medical Center
NCT07158814 Phase 4
Recruiting
Safety of RSV Preventive Monoclonal Antibody
Condition
Fever
Enrollment
524 pts
Location
United States
Sponsor
Duke University
NCT07646587 Phase 2
Recruiting
A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)
Condition
COPD (Chronic Obstructive Pulmonary Disease)
Enrollment
105 pts
Location
United States
Sponsor
Windward Bio
NCT07220811 Phase 2
Recruiting
Phase 2b Study of RPT904 as Monotherapy in Participants With IgE-Mediated Food A...
Condition
Ig-E Mediated Food Allergy
Enrollment
100 pts
Location
United States, Australia, Canada
Sponsor
RAPT Therapeutics, Inc.
NCT07207811 Phase 3
Recruiting
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine...
Condition
Transthyretin Amyloid Cardiomyopathy (ATTR CM)
Enrollment
1,280 pts
Location
United States, Argentina, Australia
Sponsor
Novo Nordisk A/S
NCT07458607 N/A
Recruiting
UNC Tobacco Convenience Store
Condition
Health Behavior
Enrollment
1,185 pts
Location
United States
Sponsor
University of North Carolina,
NCT07224334 Phase 1
Recruiting
Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin R...
Condition
Diabetes (DM)
Enrollment
30 pts
Location
United States
Sponsor
David D'Alessio, M.D.
NCT05780034 Phase 1
Recruiting
A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies
Condition
Relapsed/Refractory B-cell Malignancies
Enrollment
60 pts
Location
United States
Sponsor
Accutar Biotechnology Inc
NCT06580106 N/A
Recruiting
Toxicity Genetic Determinants and Response to Azacitidine and Venetoclax in AML
Condition
Leukemia, Myeloid, Acute
Enrollment
50 pts
Location
United States
Sponsor
Wake Forest University Health
NCT06288763 N/A
Recruiting
Nerve Transfer to Improve Function in High Level Tetraplegia
Condition
Cervical Spinal Cord Injury
Enrollment
30 pts
Location
United States, Canada
Sponsor
Washington University School o
NCT05766384 N/A
Recruiting
Hyperpolarized 129Xe MRI Lung Health Cohort
Condition
Healthy
Enrollment
260 pts
Location
United States
Sponsor
University of Kansas Medical C
NCT05735184 Phase 1
Recruiting
A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination ...
Condition
Acute Myeloid Leukemia
Enrollment
420 pts
Location
United States
Sponsor
Kura Oncology, Inc.
NCT07288138 Phase 2
Recruiting
A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicar...
Condition
Metabolic Dysfunction-associated Steatohepatitis
Enrollment
160 pts
Location
United States
Sponsor
Eccogene
NCT05663034 N/A
Recruiting
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Trauma...
Condition
Traumatic Brain Injury
Enrollment
360 pts
Location
United States
Sponsor
Johns Hopkins University
NCT06578104 N/A
Recruiting
PULSED AF Post-Approval Study
Condition
Atrial Fibrillation
Enrollment
580 pts
Location
United States, Canada, South Korea
Sponsor
Medtronic Cardiac Ablation Sol
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology