State NC
Clinical Trials in North Carolina
North Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in North Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 372 actively recruiting studies with North Carolina sites out of 372 registered in total. The busiest research areas in North Carolina are Breast Cancer, Heart Failure, Multiple Myeloma. Leading sponsors running trials in the state include Duke University, Wake Forest University Health Sciences, UNC Lineberger Comprehensive Cancer Center. By stage, North Carolina trials break down as Phase 1 (61), Phase 2 (94), Phase 3 (79), Phase 4 (12).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in North Carolina
Frequently Asked Questions — Clinical Trials in North Carolina
How many clinical trials are currently recruiting in North Carolina?
ClinicalMetric currently tracks 372 actively recruiting clinical trials with at least one location in North Carolina. The total number of registered studies—including active but not currently enrolling trials—is 372. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in North Carolina?
North Carolina hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Heart Failure, Multiple Myeloma, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout North Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in North Carolina?
To join a clinical trial in North Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in North Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in North Carolina
NCT04363684 N/A
Recruiting
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Condition
Frontotemporal Lobar Degeneration (FTLD)
Enrollment
2,100 pts
Location
United States, Canada
Sponsor
Mayo Clinic
NCT06971640 N/A
Recruiting
Advancing Identification of Circadian Delay in ADHD Youth: Associations With Cli...
Condition
ADHD - Attention Deficit Disorder With Hyperactivity
Enrollment
250 pts
Location
United States
Sponsor
Duke University
NCT04781140 Phase 4
Recruiting
Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Chi...
Condition
Attention-Deficit/Hyperactivity Disorder
Enrollment
286 pts
Location
United States
Sponsor
Supernus Pharmaceuticals, Inc.
NCT04862468 Phase 2
Recruiting
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thro...
Condition
Thrombosis, Deep Vein
Enrollment
80 pts
Location
United States, Ireland, United Kingdom
Sponsor
Mercator MedSystems, Inc.
NCT06839833 N/A
Recruiting
APOL1 Genotyping CTA Clinical Performance Study
Condition
APOL1-mediated Kidney Disease
Enrollment
2,000 pts
Location
United States
Sponsor
Almac Diagnostic Services LLC
NCT05848297 N/A
Recruiting
Automated Robotic TCD in Traumatic Brain Injury
Condition
Brain Injuries, Traumatic
Enrollment
30 pts
Location
United States
Sponsor
Virginia Commonwealth Universi
NCT06121297 Phase 1, Phase 2
Recruiting
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of C...
Condition
Systemic Lupus Erythematosus
Enrollment
28 pts
Location
United States, Canada, Spain
Sponsor
Cabaletta Bio
NCT07285213 Phase 2
Recruiting
Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Ant...
Condition
Clostridioides Difficile Infection
Enrollment
230 pts
Location
United States, Australia, Canada
Sponsor
AstraZeneca
NCT07502443 Phase 3
Recruiting
A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolep...
Condition
Narcolepsy Type 2
Enrollment
176 pts
Location
United States, Australia, Belgium
Sponsor
Alkermes, Inc.
NCT07610226 N/A
Recruiting
Post-refractive IOL Outcomes With Clareon TruPlus
Condition
Cataract
Enrollment
35 pts
Location
United States
Sponsor
Laser Defined Vision
NCT05589714 N/A
Recruiting
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystr...
Condition
Inherited Retinal Degeneration
Enrollment
1,500 pts
Location
United States, Australia, Belgium
Sponsor
Jaeb Center for Health Researc
NCT07362017 Phase 3
Recruiting
Open Label Study to Investigate the Safety and Efficacy of Ponesimod in Moderate...
Condition
Moderate-to-severe Chronic Plaque Psoriasis
Enrollment
300 pts
Location
United States
Sponsor
Vanda Pharmaceuticals
NCT07645287 Phase 2
Recruiting
A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologica...
Condition
HIV-1-infection
Enrollment
175 pts
Location
United States, Australia, Canada
Sponsor
Gilead Sciences
NCT07661355 N/A
Recruiting
Comparing Two Acute Care Transition Programs for Older Adults and Their Family C...
Condition
Care Transition
Enrollment
2,560 pts
Location
United States
Sponsor
Wake Forest University Health
NCT06249126 N/A
Recruiting
Primary Subtalar Arthrodesis for Calcaneal Fractures
Condition
Calcaneus Fracture
Enrollment
218 pts
Location
United States
Sponsor
Wake Forest University Health
NCT05462106 Phase 1, Phase 2
Recruiting
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down S...
Condition
Amyloid Plaque
Enrollment
304 pts
Location
United States, Spain, United Kingdom
Sponsor
AC Immune SA
NCT05237258 N/A
Recruiting
Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute...
Condition
Relapsed Adult AML
Enrollment
2,300 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT07226661 Phase 2
Recruiting
Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
Condition
Major Depressive Disorder (MDD)
Enrollment
230 pts
Location
United States
Sponsor
Supernus Pharmaceuticals, Inc.
NCT07406633 Phase 2
Recruiting
KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIS...
Condition
GIST - Gastrointestinal Stromal Tumor
Enrollment
46 pts
Location
United States
Sponsor
Kumquat Biosciences Inc.
NCT04427384 N/A
Recruiting
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
Condition
Brain Tumor, Recurrent
Enrollment
600 pts
Location
United States
Sponsor
GT Medical Technologies, Inc.
NCT06540833 Phase 2
Recruiting
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psycho...
Condition
Psychotic Disorders
Enrollment
370 pts
Location
United States, Bulgaria, Croatia
Sponsor
Intra-Cellular Therapies, Inc.
NCT07783152 N/A
Recruiting
Lupus Nephritis Care Pathway
Condition
Lupus Nephritis (LN)
Enrollment
25 pts
Location
United States
Sponsor
Duke University
NCT06108050 Phase 1
Recruiting
JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in...
Condition
Advanced Solid Tumor
Enrollment
177 pts
Location
United States
Sponsor
Jazz Pharmaceuticals
NCT05366179 Phase 1
Recruiting
Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3T...
Condition
Glioblastoma Multiforme
Enrollment
36 pts
Location
United States
Sponsor
UNC Lineberger Comprehensive C
NCT02469662 N/A
Recruiting
Clinical Outcomes Study of the Nexel Total Elbow
Condition
Elbow Joint Destruction
Enrollment
134 pts
Location
United States, Australia, Finland
Sponsor
Zimmer Biomet
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology