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heart failure with preserved ejection fraction

Total Trials
9
Recruiting Now
9
Trial Phases
EARLY_Phase 1, Phase 3, Phase 4

ClinicalMetric tracks all active clinical trials for heart failure with preserved ejection fraction sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — heart failure with preserved ejection fraction Clinical Trials

How many clinical trials are currently recruiting for heart failure with preserved ejection fraction?
ClinicalMetric currently tracks 9 actively recruiting clinical trials for heart failure with preserved ejection fraction, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 9. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for heart failure with preserved ejection fraction?
heart failure with preserved ejection fraction research spans Phase 1 (1 trial), Phase 2 (1 trial), Phase 3 (1 trial), Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a heart failure with preserved ejection fraction clinical trial?
Eligibility criteria for heart failure with preserved ejection fraction trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
1
Phase 2
1
Phase 3
1
Phase 4
2
Top Sponsors
Hospices Civils de Lyon 1 trial
Fundación para la Investigación del Hospital Clínico de Valencia 1 trial
The University of Texas Health Science Center at San Antonio 1 trial
Amgen 1 trial
Guangdong Provincial Hospital of Traditional Chinese Medicine 1 trial

Recruiting Clinical Trials

NCT05651919
Recruiting
PBMC as Biomarkers of Diabetic Cardiomyopathy
Enrollment
175 pts
Location
France
Sponsor
Hospices Civils de Lyon
View Trial →
NCT06992089
Recruiting
SHort Of Pace - Heart Failure (SHOP-HF)
Enrollment
30 pts
Location
Spain
Sponsor
Fundación para la Investigació...
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NCT05057806 EARLY_Phase 1
Recruiting
SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
Enrollment
30 pts
Location
United States
Sponsor
The University of Texas Health...
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NCT07037459 Phase 3
Recruiting
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Enrollment
5,056 pts
Location
United States, Argen...
Sponsor
Amgen
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NCT06377761
Recruiting
Study on Heart Failure with Preserved Ejection Fraction with Qishen Granules
Enrollment
80 pts
Location
China
Sponsor
Guangdong Provincial Hospital ...
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NCT07918209
Recruiting
Remote Rehabilitation in Patients With HFpEF (PATRON-HF)
Enrollment
110 pts
Location
Poland
Sponsor
American Heart of Poland
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NCT06249945 Phase 4
Recruiting
EMPAgliflozin in Heart Failure With PReserved Ejection Fraction and End Stage Renal Disease
Enrollment
150 pts
Location
Taiwan
Sponsor
National Taiwan University Hos...
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NCT05991128 Phase 4
Recruiting
The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life
Enrollment
170 pts
Location
China
Sponsor
China-Japan Friendship Hospita...
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NCT07202000 Phase 2
Recruiting
EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)
Enrollment
48 pts
Location
United States
Sponsor
Massachusetts General Hospital
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Related Conditions

heart failure with mildly reduced ejection fraction (2) type 2 diabetes (1) metabolic syndrome (1) type2 diabetes (1) obesity (1) end stage renal disease on dialysis (1) iron deficiencies (1) acute heart failure (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology