State NC
Clinical Trials in North Carolina
North Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in North Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 420 actively recruiting studies with North Carolina sites out of 420 registered in total. The busiest research areas in North Carolina are Breast Cancer, Acute Myeloid Leukemia, Cancer. Leading sponsors running trials in the state include Duke University, Wake Forest University Health Sciences, National Cancer Institute (NCI). By stage, North Carolina trials break down as Phase 1 (67), Phase 2 (115), Phase 3 (110), Phase 4 (20).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in North Carolina
Frequently Asked Questions — Clinical Trials in North Carolina
How many clinical trials are currently recruiting in North Carolina?
ClinicalMetric currently tracks 420 actively recruiting clinical trials with at least one location in North Carolina. The total number of registered studies—including active but not currently enrolling trials—is 420. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in North Carolina?
North Carolina hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Acute Myeloid Leukemia, Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout North Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in North Carolina?
To join a clinical trial in North Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in North Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in North Carolina
NCT04588922 Phase 1, Phase 2
Recruiting
Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Pa...
Condition
Hematologic Malignancies
Enrollment
160 pts
Location
United States, China
Sponsor
Sellas Life Sciences Group
NCT05691465 Phase 2
Recruiting
Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 1...
Condition
Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation
Enrollment
35 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT06632977 Phase 2
Recruiting
Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial
Condition
Castration-Resistant Prostate Carcinoma
Enrollment
474 pts
Location
United States
Sponsor
Alliance for Clinical Trials i
NCT07215572 N/A
Recruiting
Implementing a Group Physical Therapy Program for Veterans (GroupPT): Function Q...
Condition
Knee Osteoarthritis
Enrollment
20 pts
Location
United States
Sponsor
VA Office of Research and Deve
NCT06195072 Phase 2
Recruiting
Platform Clinical Study for Conquering Scleroderma
Condition
Interstitial Lung Disease Due to Systemic Disease
Enrollment
400 pts
Location
United States
Sponsor
Scleroderma Research Foundatio
NCT07732829 N/A
Recruiting
FlexED: Full Threshold ED Substudy
Condition
Eating Disorders
Enrollment
6 pts
Location
United States
Sponsor
Duke University
NCT05712057 N/A
Recruiting
Neurostimulation Versus Therapy for Problems With Emotions
Condition
Emotion Regulation
Enrollment
240 pts
Location
United States
Sponsor
Duke University
NCT07605429 Phase 3
Recruiting
BEACON - Phase III Clinical Study of Rugonersen in Angelman Syndrome.
Condition
Angelman Syndrome
Enrollment
165 pts
Location
United States, South Korea, Taiwan
Sponsor
OHB Pediatrics Ltd.
NCT07173751 Phase 3
Recruiting
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-N...
Condition
Breast Neoplasms
Enrollment
558 pts
Location
United States, Argentina, Australia
Sponsor
BioNTech SE
NCT07406633 Phase 2
Recruiting
KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIS...
Condition
GIST - Gastrointestinal Stromal Tumor
Enrollment
46 pts
Location
United States
Sponsor
Kumquat Biosciences Inc.
NCT05673408 N/A
Recruiting
NIBP Validation Study
Condition
Critical Illness
Enrollment
189 pts
Location
United States
Sponsor
Philips Clinical & Medical Aff
NCT07003425 Phase 2
Recruiting
A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis
Condition
Atopic Dermatitis
Enrollment
350 pts
Location
United States, Canada, Czechia
Sponsor
Apogee Therapeutics, Inc.
NCT02493478 N/A
Recruiting
Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs
Condition
Failed or Difficult Intubation, Sequela
Enrollment
150,000 pts
Location
United States, Australia, Austria
Sponsor
Children's Hospital of Philade
NCT06618274 N/A
Recruiting
Effectiveness of Central Oncology Navigation and the Use of an ORN
Condition
Cancer
Enrollment
686 pts
Location
United States
Sponsor
UNC Lineberger Comprehensive C
NCT07082738 Phase 2
Recruiting
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Ve...
Condition
Chronic Obstructive Pulmonary Disease (COPD)
Enrollment
987 pts
Location
United States, Argentina, Australia
Sponsor
AstraZeneca
NCT06177717 N/A
Recruiting
Deep Functional Phenotyping of the ALA Lung Health Cohort
Condition
Lung Diseases
Enrollment
1,000 pts
Location
United States
Sponsor
Johns Hopkins University
NCT06999187 Phase 1
Recruiting
A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or ...
Condition
Triple Negative Breast Cancer
Enrollment
96 pts
Location
United States
Sponsor
Dren Bio
NCT07213804 Phase 3
Recruiting
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum...
Condition
Ovarian Neoplasms
Enrollment
1,630 pts
Location
United States, Australia, Austria
Sponsor
Eli Lilly and Company
NCT07577843 Phase 3
Recruiting
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn...
Condition
Crohn Disease
Enrollment
460 pts
Location
United States, Argentina, Australia
Sponsor
Janssen Research & Development
NCT06567704 N/A
Recruiting
Cancer-related Fatigue During Maintenance Immunotherapy for Non-small Cell Lung ...
Condition
Non-small Cell Lung Cancer
Enrollment
20 pts
Location
United States
Sponsor
Wake Forest University Health
NCT02327897 N/A
Recruiting
NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)
Condition
Asthma
Enrollment
400 pts
Location
United States
Sponsor
National Institute of Environm
NCT05685303 N/A
Recruiting
Alleviant ALLAY-HF Study
Condition
Heart Failure
Enrollment
700 pts
Location
United States, Australia, Austria
Sponsor
Alleviant Medical, Inc.
NCT02343042 Phase 1, Phase 2
Recruiting
Selinexor and Backbone Treatments of Multiple Myeloma Patients
Condition
Multiple Myeloma
Enrollment
300 pts
Location
United States, Canada
Sponsor
Karyopharm Therapeutics Inc
NCT06974786 Phase 2
Recruiting
Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurabl...
Condition
Multiple Myeloma, Newly Diagnosed
Enrollment
100 pts
Location
United States
Sponsor
SCRI Development Innovations,
NCT07317505 Phase 1
Recruiting
A Phase 1 Study of JMT108 in Participants With Advanced Solid Tumors
Condition
Cancer
Enrollment
270 pts
Location
United States
Sponsor
Conjupro Biotherapeutics, Inc.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology