State NC
Clinical Trials in North Carolina
North Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in North Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 420 actively recruiting studies with North Carolina sites out of 420 registered in total. The busiest research areas in North Carolina are Breast Cancer, Acute Myeloid Leukemia, Cancer. Leading sponsors running trials in the state include Duke University, Wake Forest University Health Sciences, National Cancer Institute (NCI). By stage, North Carolina trials break down as Phase 1 (67), Phase 2 (115), Phase 3 (110), Phase 4 (20).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in North Carolina
Frequently Asked Questions — Clinical Trials in North Carolina
How many clinical trials are currently recruiting in North Carolina?
ClinicalMetric currently tracks 420 actively recruiting clinical trials with at least one location in North Carolina. The total number of registered studies—including active but not currently enrolling trials—is 420. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in North Carolina?
North Carolina hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Acute Myeloid Leukemia, Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout North Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in North Carolina?
To join a clinical trial in North Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in North Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in North Carolina
NCT06925542 Phase 1
Recruiting
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory ...
Condition
SLE (Systemic Lupus)
Enrollment
80 pts
Location
United States, Germany, Spain
Sponsor
CRISPR Therapeutics
NCT07532603 Phase 2, Phase 3
Recruiting
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
Condition
Lichen Planopilaris
Enrollment
342 pts
Location
United States, Australia, Canada
Sponsor
Priovant Therapeutics, Inc.
NCT07166861 N/A
Recruiting
Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adult...
Condition
Aging
Enrollment
7,140 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT06765642 N/A
Recruiting
The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Str...
Condition
Stroke
Enrollment
26 pts
Location
United States
Sponsor
Duke University
NCT04943861 N/A
Recruiting
Human Immunodeficiency Virus (HIV) Food Insecurities
Condition
Food Insecurities
Enrollment
200 pts
Location
United States
Sponsor
Wake Forest University Health
NCT05734066 Phase 1, Phase 2
Recruiting
Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants Wit...
Condition
Refractory Ewing Sarcoma
Enrollment
60 pts
Location
United States, Canada
Sponsor
Jazz Pharmaceuticals
NCT04657822 Phase 4
Recruiting
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior ...
Condition
Sickle Cell Disease
Enrollment
130 pts
Location
United States, Belgium, Brazil
Sponsor
Novartis Pharmaceuticals
NCT07226986 Phase 1, Phase 2
Recruiting
A Phase Ib/II Open-label Study of AMO959 With Lutetium (177Lu) Vipivotide Tetrax...
Condition
PSMA-positive Metastatic Castration Resistant Prostate Cancer (mCRPC) With Prior Exposure to One Prior ARPI Who Are Candidates for Taxane-based Chemotherapy
Enrollment
123 pts
Location
United States, Australia, France
Sponsor
Novartis Pharmaceuticals
NCT07901751 Phase 2, Phase 3
Recruiting
Study to Evaluate the Efficacy of a Single Intravitreal Injection of RTx-015 in ...
Condition
Retinitis Pigmentosa (RP)
Enrollment
60 pts
Location
United States
Sponsor
Ray Therapeutics, Inc.
NCT07768345 Phase 3
Recruiting
A Study to Learn About Revaccination With a Vaccine Called RSVpreF in Immunocomp...
Condition
Respiratory Syncytial Virus (RSV)
Enrollment
440 pts
Location
United States
Sponsor
Pfizer
NCT06458075 N/A
Recruiting
Intervention to Improve Communication and Medication Adherence in Lupus
Condition
Systemic Lupus Erythematosus
Enrollment
480 pts
Location
United States
Sponsor
Duke University
NCT05437575 Phase 3
Recruiting
Prehospital Analgesia INtervention Trial (PAIN)
Condition
Traumatic Injury
Enrollment
994 pts
Location
United States
Sponsor
Jason Sperry
NCT05885412 Phase 1
Recruiting
A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediat...
Condition
PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)
Enrollment
9 pts
Location
United States
Sponsor
Rocket Pharmaceuticals Inc.
NCT05907629 N/A
Recruiting
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vasc...
Condition
Stroke
Enrollment
300 pts
Location
United States
Sponsor
Yale University
NCT04221542 Phase 1
Recruiting
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate C...
Condition
Prostate Cancer
Enrollment
505 pts
Location
United States, Australia, China
Sponsor
Amgen
NCT06738394 N/A
Recruiting
Enhancing Physical Function in Older Adults With Chronic Kidney Disease
Condition
Chronic Kidney Diseases
Enrollment
30 pts
Location
United States
Sponsor
Wake Forest University Health
NCT04889872 N/A
Recruiting
PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAV...
Condition
Aortic Stenosis, Calcific
Enrollment
2,250 pts
Location
United States, Australia, Canada
Sponsor
Edwards Lifesciences
NCT06658912 N/A
Recruiting
Planning Grant for TOPS for Breast Cancer Survivors
Condition
Breast Cancer
Enrollment
25 pts
Location
United States
Sponsor
Duke University
NCT07766005 Phase 2
Recruiting
A Study of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa (Th...
Condition
Hidradenitis Suppurativa (HS)
Enrollment
150 pts
Location
United States, Canada
Sponsor
Spyre Therapeutics, Inc.
NCT04903795 Phase 1
Recruiting
BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma
Condition
Newly Diagnosed Glioblastoma
Enrollment
18 pts
Location
United States
Sponsor
Mustafa Khasraw, MBChB, MD, FR
NCT06636383 N/A
Recruiting
Glycogen Storage Disease Type Ia (GSDIa) Disease Monitoring Program
Condition
Glycogen Storage Disease Type Ia
Enrollment
140 pts
Location
United States, Brazil, Canada
Sponsor
Ultragenyx Pharmaceutical Inc
NCT07405983 N/A
Recruiting
TOUCH® CMC 1 New Enrollment US Study
Condition
Osteoarthritis Thumb
Enrollment
163 pts
Location
United States
Sponsor
Keri Medical SA
NCT04592445 N/A
Recruiting
Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having H...
Condition
Heart Failure With Preserved Ejection Fraction (HFpEF
Enrollment
150 pts
Location
United States, Georgia
Sponsor
Axon Therapies, Inc.
NCT07654361 Phase 3
Recruiting
Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight W...
Condition
Obesity
Enrollment
3,600 pts
Location
United States
Sponsor
Gasherbrum Bio, Inc., a wholly
NCT06001788 Phase 1
Recruiting
Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Ref...
Condition
AML
Enrollment
171 pts
Location
United States, Italy, Spain
Sponsor
Kura Oncology, Inc.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology