NCT06765642 The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.
| NCT ID | NCT06765642 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Duke University |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 26 participants |
| Start Date | 2025-06-09 |
| Primary Completion | 2027-04-13 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 26 participants in total. It began in 2025-06-09 with a primary completion date of 2027-04-13.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better.
Eligibility Criteria
Inclusion criteria: 1. Age \>=21 years old of any race or gender 2. First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 3 months from stroke onset 3. Unilateral arm weakness measured by FM-UM scale \<= 62 out of 66 4. Inducible rest motor threshold and testing motor threshold recorded from the affected first dorsal interosseous (FDI) muscle from the study subject Exclusion criteria 1. Bilateral strokes (infarcts and/or hematoma) 2. Other co-existent neuromuscular disorders affecting upper extremity motor impairment. 3. History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study. 4. Uncontrolled hypertension despite medical treatment(s) at the time of randomization, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and randomized later). 5. Presence of any MRI/rTMS risk factors including but not limited to: 1. an electrically, magnetically, or mechanically activated metallic or nonmetallic implant including cardiac pacemaker, intracerebral vascular clips or any other electrically sensitive support system. 2. a non-fixed metallic part in any part of the body, including a previous metallic injury to the eye. 3. history of seizure disorder before stroke or seizure after stroke. 4. preexisting scalp lesion or bone defect or hemicraniectomy. 6. Concurrent enrollment in another interventional stroke recovery study. 7. Concerns that the subject cannot comply with study procedures and visits. 8. Pregnant individuals
Contact & Investigator
Wayne Feng, MD
PRINCIPAL INVESTIGATOR
Duke University
Frequently Asked Questions
Who can join the NCT06765642 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06765642 currently recruiting?
Yes, NCT06765642 is actively recruiting participants. Contact the research team at wayne.feng@duke.edu for enrollment information.
Where is the NCT06765642 trial being conducted?
This trial is being conducted at Durham, United States.
Who is sponsoring the NCT06765642 clinical trial?
NCT06765642 is sponsored by Duke University. The principal investigator is Wayne Feng, MD at Duke University. The trial plans to enroll 26 participants.
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