NCT06738394 Enhancing Physical Function in Older Adults With Chronic Kidney Disease
| NCT ID | NCT06738394 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Wake Forest University Health Sciences |
| Condition | Chronic Kidney Diseases |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-07-31 |
| Primary Completion | 2027-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2025-07-31 with a primary completion date of 2027-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an attention control condition consisting of weekly group sessions covering topics on healthy lifestyle. This study seeks to: 1. Determine whether implementing an HVRT intervention is feasible and safe for mobility-limited older adults with advanced CKD. 2. Collect preliminary data on the efficacy of HVRT for improving muscle power and physical function in mobility-limited older adults with advanced CKD.
Eligibility Criteria
Inclusion Criteria: * Chronic kidney disease stages 3-5 * Capacity to complete physical exercise * Lives within 20 miles of Wake Forest Reynolda Campus * Fluent English speaker * Does not plan to travel outside of home area for an extended period of time during study * Willing to be randomized to either intervention group Exclusion Criteria: * Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months * Dependent on a wheelchair * Current participation in a resistance training program * Joint replacement or orthopedic surgery in the previous 6 months or planning to have surgery in the next 6 months months * Absolute contraindications to exercise testing according to ACSM: Acute myocardial infarction within the past 6 months Ongoing unstable angina Uncontrolled cardiac arrhythmia with hemodynamic compromise Active endocarditis Symptomatic severe aortic stenosis Decompensated heart failure Acute pulmonary embolism, pulmonary infarction, or deep venous thrombosis Acute myocarditis or pericarditis Acute aortic dissection * Parkinson's disease * Respiratory disease requiring oxygen * Cancer requiring treatment * Currently receiving physical therapy or cardiopulmonary rehabilitation * Type I or insulin dependent Type II Diabetes * Scoring below 32 points on the Telephone Interview for Cognitive Status (TICS) * Site PI/Study Clinician discretion regarding medical status, appropriateness of participation or concern about intervention adherence
Contact & Investigator
Eliott Arroyo, PhD
PRINCIPAL INVESTIGATOR
Wake Forest University Health Sciences
Frequently Asked Questions
Who can join the NCT06738394 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, up to 100 Years, studying Chronic Kidney Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06738394 currently recruiting?
Yes, NCT06738394 is actively recruiting participants. Contact the research team at epicstudy@wfu.edu for enrollment information.
Where is the NCT06738394 trial being conducted?
This trial is being conducted at Winston-Salem, United States.
Who is sponsoring the NCT06738394 clinical trial?
NCT06738394 is sponsored by Wake Forest University Health Sciences. The principal investigator is Eliott Arroyo, PhD at Wake Forest University Health Sciences. The trial plans to enroll 30 participants.
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