Enhancing Physical Function in Older Adults With Chronic Kidney Disease
Trial Parameters
Brief Summary
The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an attention control condition consisting of weekly group sessions covering topics on healthy lifestyle. This study seeks to: 1. Determine whether implementing an HVRT intervention is feasible and safe for mobility-limited older adults with advanced CKD. 2. Collect preliminary data on the efficacy of HVRT for improving muscle power and physical function in mobility-limited older adults with advanced CKD.
Eligibility Criteria
Inclusion Criteria: * Chronic kidney disease stages 3-5 * Capacity to complete physical exercise * Lives within 20 miles of Wake Forest Reynolda Campus * Fluent English speaker * Does not plan to travel outside of home area for an extended period of time during study * Willing to be randomized to either intervention group Exclusion Criteria: * Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months * Dependent on a wheelchair * Current participation in a resistance training program * Joint replacement or orthopedic surgery in the previous 6 months or planning to have surgery in the next 6 months months * Absolute contraindications to exercise testing according to ACSM: Acute myocardial infarction within the past 6 months Ongoing unstable angina Uncontrolled cardiac arrhythmia with hemodynamic compromise Active endocarditis Symptomatic severe aortic stenosis Decompensated heart failure Acute pulm