Browse by Phase
Phase 1 / Phase 2 Clinical Trials
Phase 1/2 combined trials evaluate both safety (Phase 1) and preliminary efficacy (Phase 2) in a single study protocol, often used to accelerate early development.
Total Trials
401
Recruiting Now
401
Top Conditions in Phase 1 / Phase 2
Frequently Asked Questions — Phase 1 / Phase 2 Trials
What are combined Phase 1/2 clinical trials?
Phase 1/2 trials are adaptive designs that evaluate both safety (Phase 1 objectives) and preliminary efficacy (Phase 2 objectives) within a single trial protocol. They are commonly used in oncology and rare disease research to accelerate development timelines. Dose escalation occurs in the Phase 1 portion, followed by expansion cohorts at the selected dose in the Phase 2 portion.
Why do sponsors combine Phase 1 and Phase 2?
Combining phases reduces development time and cost, particularly for conditions with high unmet need. For rare diseases or cancer indications, finding sufficient eligible patients can be challenging—a combined design uses the same patient pool more efficiently. Regulatory agencies including the FDA encourage adaptive designs to accelerate evidence generation for serious conditions.
How do I find Phase 1/2 trials I can join?
Phase 1/2 trials listed on ClinicalMetric are sourced from ClinicalTrials.gov and filtered by recruitment status. Each listing shows enrollment status, conditions studied, sponsor, participating sites, and estimated enrollment. Because Phase 1/2 trials often have narrow eligibility criteria, carefully review the protocol and discuss potential participation with your treating physician.
Active Phase 1 / Phase 2 Studies
NCT07399821 Phase 1, Phase 2
Recruiting
An Imaging Study of Anti-GD2-800CW in Patients With Neuroblastoma
Condition
Neuroblastoma
Enrollment
22 pts
Location
Netherlands
Sponsor
Princess Maxima Center for Ped
NCT06844214 Phase 1, Phase 2
Recruiting
A Study to Investigate the Safety, Tolerability, and Efficacy of SAR446268, an A...
Condition
Myotonic Dystrophy
Enrollment
32 pts
Location
United States, Argentina, Australia
Sponsor
Sanofi
NCT07073534 Phase 1, Phase 2
Recruiting
Phase I/II Clinical Study of SHR-1501 Combined With Adbelizumab in Patients With...
Condition
Patients With Advanced or Metastatic Malignant Tumors
Enrollment
203 pts
Location
China
Sponsor
Shanghai Hengrui Pharmaceutica
NCT05296564 Phase 1, Phase 2
Recruiting
Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes Given by Infusion to Patients With...
Condition
Sarcoma, Synovial
Enrollment
3 pts
Location
Israel
Sponsor
Hadassah Medical Organization
NCT05981014 Phase 1, Phase 2
Recruiting
Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant...
Condition
Breast Neoplasms
Enrollment
196 pts
Location
China
Sponsor
Sun Yat-Sen Memorial Hospital
NCT06750302 Phase 1, Phase 2
Recruiting
Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial
Condition
Chronic Rhinosinusitis (CRS)
Enrollment
100 pts
Location
Canada
Sponsor
St. Paul's Hospital, Canada
NCT07281781 Phase 1, Phase 2
Recruiting
Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore...
Condition
Myelofibrosis
Enrollment
10 pts
Location
United States
Sponsor
University of California, Irvi
NCT07660614 Phase 1, Phase 2
Recruiting
A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis
Condition
Amyotrophic Lateral Sclerosis
Enrollment
56 pts
Location
Germany, Italy, Netherlands
Sponsor
Leal Therapeutics, Inc
NCT07718581 Phase 1, Phase 2
Recruiting
HMPL-A830 in Solid Tumors
Condition
Solid Tumor, Adult
Enrollment
147 pts
Location
United States, China
Sponsor
Hutchmed
NCT07539441 Phase 1, Phase 2
Recruiting
A Study of Mirdametinib in People With Central Nervous System Tumors
Condition
Central Nervous System Tumors
Enrollment
26 pts
Location
United States
Sponsor
Memorial Sloan Kettering Cance
NCT05315167 Phase 1, Phase 2
Recruiting
A Phase I/II Study to Evaluate the Safety, Pharmacokinetics and Efficacy of PRJ1...
Condition
Advanced Solid Tumor
Enrollment
267 pts
Location
China
Sponsor
Zhuhai Yufan Biotechnologies C
NCT07350707 Phase 1, Phase 2
Recruiting
Diagnostic Value of CXCR4-targeted PET/CT in ACTH-dependent and Independent Cush...
Condition
Cushing s Syndrome
Enrollment
160 pts
Location
China
Sponsor
Peking Union Medical College H
NCT05987644 Phase 1, Phase 2
Recruiting
Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients Wi...
Condition
Lung Cancer
Enrollment
56 pts
Location
United States
Sponsor
Joshua Palmer
NCT07657234 Phase 1, Phase 2
Recruiting
tDCS for Late-Life Depression
Condition
Late Life Depression (LLD)
Enrollment
20 pts
Location
United States
Sponsor
Andre Russowsky Brunoni
NCT06725121 Phase 1, Phase 2
Recruiting
Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Trans...
Condition
Hepatocellular Carcinoma (HCC)
Enrollment
48 pts
Location
Canada
Sponsor
University Health Network, Tor
NCT07630974 Phase 1, Phase 2
Recruiting
A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refr...
Condition
Malignant Neoplasm
Enrollment
134 pts
Location
United States, Australia, Belgium
Sponsor
Merck Sharp & Dohme LLC
NCT04997317 Phase 1, Phase 2
Recruiting
Treatment of Recurrent or Progressive Meningiomas With the Radiolabelled Somatos...
Condition
Meningioma
Enrollment
18 pts
Location
Switzerland
Sponsor
University Hospital, Basel, Sw
NCT07610486 Phase 1, Phase 2
Recruiting
Optimizing PreTerm Infant Ampicillin Dosing
Condition
Early Onset Sepsis
Enrollment
60 pts
Location
United States
Sponsor
Duke University
NCT07298408 Phase 1, Phase 2
Recruiting
Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot Study
Condition
Diabetic Peripheral Neuropathic Pain (DPN)
Enrollment
20 pts
Location
United States
Sponsor
Florida A&M University
NCT07701486 Phase 1, Phase 2
Recruiting
A Study of More Frequent Dosing of VCN-01 Combined With Standard Chemotherapy in...
Condition
Pancreas Cancer, Metastatic
Enrollment
6 pts
Location
Spain
Sponsor
Theriva Biologics SL
NCT07668518 Phase 1, Phase 2
Recruiting
A Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of KIT2014 in...
Condition
Chronic Obstructive Pulmonary Disease (COPD)
Enrollment
36 pts
Location
Australia
Sponsor
Kither Biotech Srl
NCT07863180 Phase 1, Phase 2
Recruiting
Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial
Condition
Parkinson Disease
Enrollment
15 pts
Location
United States
Sponsor
Prabesh Kanel
NCT07102342 Phase 1, Phase 2
Recruiting
This Clinical Trial is Designed to Evaluate the Safety, Tolerability, Feasibilit...
Condition
Parkinson Disease
Enrollment
5 pts
Location
United States
Sponsor
iRegene Therapeutics Co., Ltd.
NCT06207123 Phase 1, Phase 2
Recruiting
A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relap...
Condition
Acute Leukemia
Enrollment
15 pts
Location
United States
Sponsor
University of Chicago
NCT07278479 Phase 1, Phase 2
Recruiting
Study of [212Pb]Pb-DOTAM-MAM279 ([212Pb]Pb-MP0712) in Patients With Small Cell L...
Condition
Large Cell Neuroendocrine Carcinoma
Enrollment
138 pts
Location
United States
Sponsor
Molecular Partners AG
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology