Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan
Trial Parameters
Brief Summary
The purpose of this study is to evaluate the efficacy of Losartan use post-operatively for reducing or preventing the development of arthrofibrosis and the associated adverse impacts on clinical outcomes.
Eligibility Criteria
Inclusion Criteria: 1. Planned primary total knee arthroplasty of a single knee; 2. Male or female ≥ 18 years of age; 3. Capacity to personally give informed consent (consent via legally authorized representative will not be accepted) and who are willing to comply with all study-related procedures and assessments. Exclusion Criteria: 1. Breastfeeding, pregnant, or planning to become pregnant during participation in the study; 2. Diagnosed with inflammatory or other arthritis caused by autoimmune disease affecting the study knee; 3. Previous knee arthroplasty on the study knee; 4. Previous infection affecting the study knee; 5. Planned total knee arthroplasty of contralateral knee to occur at any point during the study participation period; 6. Are hypotensive as confirmed by Principal Clinical Investigator or appropriate designee; 7. Planned lower extremity surgery (other than TKA in the study leg) for the duration of study participation; 8. Any condition other than knee osteoarthritis