Browse by Phase
Phase 1 / Phase 2 Clinical Trials
Phase 1/2 combined trials evaluate both safety (Phase 1) and preliminary efficacy (Phase 2) in a single study protocol, often used to accelerate early development.
Total Trials
360
Recruiting Now
360
Top Conditions in Phase 1 / Phase 2
NCT05189093 Phase 1, Phase 2
Recruiting
Recombinant Humanized Anti-CD47/PD-1 Bifunctional Antibody HX009 in Patients Wit...
Condition
Relapsed/Refractory Lymphoma
Enrollment
99 pts
Location
China
Sponsor
Hangzhou Hanx Biopharmaceutica
NCT07227857 Phase 1, Phase 2
Recruiting
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related D...
Condition
Epileptic Encephalopathy
Enrollment
20 pts
Location
United States, France, Italy
Sponsor
Institut de Recherches Interna
NCT07477639 Phase 1, Phase 2
Recruiting
Treatment of Participants With Primary or Secondary Progressive Multiple Scleros...
Condition
Primary Progressive Multiple Sclerosis
Enrollment
39 pts
Location
United States
Sponsor
Tr1X, Inc.
NCT05207657 Phase 1, Phase 2
Recruiting
Lentiviral Gene Therapy for p47 AR-CGD
Condition
P47-Phox, Deficiency of
Enrollment
5 pts
Location
United Kingdom
Sponsor
Great Ormond Street Hospital f
NCT07374328 Phase 1, Phase 2
Recruiting
Triple Hypoglycemic Regimens In Patients With Newly Diagnosed Type 2 Diabetes Me...
Condition
Type 2 Diabetes
Enrollment
240 pts
Location
China
Sponsor
Second Affiliated Hospital of
NCT06647901 Phase 1, Phase 2
Recruiting
Efficacy of ICG-based NIR Imaging in Intralesional Curettage of Giant Cell Tumor...
Condition
Giant Cell Tumor of Bone
Enrollment
45 pts
Location
China
Sponsor
Tang Xiaodong
NCT05922930 Phase 1, Phase 2
Recruiting
Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delive...
Condition
Pancreatic Cancer
Enrollment
51 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
NCT06685042 Phase 1, Phase 2
Recruiting
Anti-CD19 CAR T-Cell Therapy in Refractory Systemic Autoimmune Diseases
Condition
Lupus Erythematosus, Systemic
Enrollment
8 pts
Location
Italy
Sponsor
Fondazione Policlinico Univers
NCT06118086 Phase 1, Phase 2
Recruiting
Study of REM-422 in Patients With Recurrent, Metastatic, or Unresectable Adenoid...
Condition
Adenoid Cystic Carcinoma
Enrollment
100 pts
Location
United States, France
Sponsor
Remix Therapeutics
NCT06639256 Phase 1, Phase 2
Recruiting
Phase 1/2 Clinical Study of HY07121 Powder for Solution for Infusion in Patients...
Condition
Safety
Enrollment
258 pts
Location
China
Sponsor
Sichuan Huiyu Pharmaceutical C
NCT05838729 Phase 1, Phase 2
Recruiting
Study of RiMO-301 and Radiotherapy With PD-1 Inhibitor for the Treatment of Head...
Condition
Head Neck Cancer
Enrollment
16 pts
Location
United States
Sponsor
Coordination Pharmaceuticals,
NCT05024214 Phase 1, Phase 2
Recruiting
Phase Ib/II Trial of Envafolimab Plus Lenvatinib for Subjects With Solid Tumors
Condition
Solid Tumors
Enrollment
170 pts
Location
China
Sponsor
3D Medicines (Sichuan) Co., Lt
NCT06512051 Phase 1, Phase 2
Recruiting
A Trial of SHR-A2102 With Adebrelimab With or Without Other Antitumor Therapy in...
Condition
Advanced or Metastatic Non-small Cell Lung Cancer
Enrollment
248 pts
Location
China
Sponsor
Shanghai Hengrui Pharmaceutica
NCT07032129 Phase 1, Phase 2
Recruiting
Sequential CAR-T Cells Targeting BCMA/GPRC5D in Patients With Relapsed/ Refracto...
Condition
Multiple Myeloma
Enrollment
60 pts
Location
China
Sponsor
Essen Biotech
NCT07488897 Phase 1, Phase 2
Recruiting
RIG 101 Trial in Healthy Adults and Adults With Asthma
Condition
Healthy Adult Participants
Enrollment
82 pts
Location
United Kingdom
Sponsor
RIGImmune Inc.
NCT07419243 Phase 1, Phase 2
Recruiting
Tolerance Results and Immune Mechanisms in Cow´s Milk and/or Hen´s Egg Allergic ...
Condition
Food Allergy in Children
Enrollment
68 pts
Location
Spain
Sponsor
Fundación de Investigación Bio
NCT06959615 Phase 1, Phase 2
Recruiting
A Phase I/IIa Study of JAB-23E73 in Patients With Advanced Solid Tumors Harborin...
Condition
Advanced Solid Tumor
Enrollment
334 pts
Location
China
Sponsor
Jacobio Pharmaceuticals Co., L
NCT05301608 Phase 1, Phase 2
Recruiting
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
Condition
Healthy
Enrollment
30 pts
Location
United States
Sponsor
Johns Hopkins University
NCT06618235 Phase 1, Phase 2
Recruiting
Trial of THEO-260 in Ovarian Cancer Patients
Condition
Ovarian Cancer
Enrollment
28 pts
Location
United Kingdom
Sponsor
Theolytics Limited
NCT07099430 Phase 1, Phase 2
Recruiting
A Trial of LBL-024 Monotherapy, LBL-024 Combined With LBL-007 or Toripalimab in ...
Condition
Advanced Melanoma
Enrollment
200 pts
Location
China
Sponsor
Nanjing Leads Biolabs Co.,Ltd
NCT06580301 Phase 1, Phase 2
Recruiting
Study of YK012 in B-cell Acute Lymphoblastic Leukemia
Condition
B-cell Acute Lymphoblastic Leukemia
Enrollment
46 pts
Location
China
Sponsor
Excyte Biopharma Ltd
NCT06249919 Phase 1, Phase 2
Recruiting
A Phase 1b/2a, Study Evaluating the Safety, PK/PD and Efficacy of NS101 in Healt...
Condition
Seneorineural Deafness
Enrollment
138 pts
Location
South Korea
Sponsor
Neuracle Science Co., LTD.
NCT07155200 Phase 1, Phase 2
Recruiting
Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK T...
Condition
Small-cell Lung Cancer
Enrollment
42 pts
Location
United States
Sponsor
Washington University School o
NCT03949881 Phase 1, Phase 2
Recruiting
Cultured Autologous Oral Mucosa Epithelial Sheet for the Treatment of Bilateral ...
Condition
Total Bilateral Limbal Cell Deficiency
Enrollment
40 pts
Location
France
Sponsor
Hospices Civils de Lyon
NCT06199557 Phase 1, Phase 2
Recruiting
A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-...
Condition
Acute Myeloid Leukemia, Adult
Enrollment
48 pts
Location
Norway
Sponsor
Haukeland University Hospital