State SC
Clinical Trials in South Carolina
South Carolina is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in South Carolina and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 167 actively recruiting studies with South Carolina sites out of 167 registered in total. The busiest research areas in South Carolina are Heart Failure, Stroke, Depression. Leading sponsors running trials in the state include Medical University of South Carolina, AstraZeneca, VA Office of Research and Development. By stage, South Carolina trials break down as Phase 1 (13), Phase 2 (33), Phase 3 (55), Phase 4 (5).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in South Carolina
Frequently Asked Questions — Clinical Trials in South Carolina
How many clinical trials are currently recruiting in South Carolina?
ClinicalMetric currently tracks 167 actively recruiting clinical trials with at least one location in South Carolina. The total number of registered studies—including active but not currently enrolling trials—is 167. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in South Carolina?
South Carolina hosts clinical trials across a broad range of medical conditions, including Heart Failure, Stroke, Depression, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout South Carolina serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in South Carolina?
To join a clinical trial in South Carolina, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in South Carolina maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in South Carolina
NCT07634705 N/A
Recruiting
Digitally Enhanced Stepped-Care for Depression in Primary Care
Condition
Depression
Enrollment
40 pts
Location
United States
Sponsor
Medical University of South Ca
NCT07186101 Phase 2
Recruiting
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately ...
Condition
Ulcerative Colitis
Enrollment
252 pts
Location
United States, Austria, Brazil
Sponsor
Eli Lilly and Company
NCT07204275 Phase 2, Phase 3
Recruiting
Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants...
Condition
Primary Membranous Nephropathy
Enrollment
176 pts
Location
United States, Australia, Brazil
Sponsor
Vertex Pharmaceuticals Incorpo
NCT03417960 N/A
Recruiting
Accelerated iTBS for Post Partum Depression
Condition
Post Partum Depression
Enrollment
40 pts
Location
United States
Sponsor
Medical University of South Ca
NCT06351605 N/A
Recruiting
A Registry Study to Assess Photobiomodulation in Dry Age-Related Macular Degener...
Condition
Dry Age-related Macular Degeneration
Enrollment
500 pts
Location
United States, Norway
Sponsor
LumiThera, Inc.
NCT06767514 Phase 3
Recruiting
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patie...
Condition
Non-Small Cell Lung Cancer
Enrollment
780 pts
Location
United States, Belgium, Canada
Sponsor
Summit Therapeutics
NCT07116967 Phase 3
Recruiting
Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants Wit...
Condition
Plaque Psoriasis
Enrollment
3,040 pts
Location
United States, Argentina, Australia
Sponsor
Bristol-Myers Squibb
NCT06538636 N/A
Recruiting
Prediction Augmented Screening Initiative
Condition
Lung Cancer
Enrollment
23,520 pts
Location
United States
Sponsor
VA Office of Research and Deve
NCT06740630 Phase 3
Recruiting
A Study on the Immune Response and Safety of an Investigational Chickenpox Vacci...
Condition
Chickenpox
Enrollment
1,840 pts
Location
United States, Belgium, Colombia
Sponsor
GlaxoSmithKline
NCT05677971 Phase 3
Recruiting
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People ...
Condition
Alpha1-Antitrypsin Deficiency
Enrollment
160 pts
Location
United States, Australia, Austria
Sponsor
Takeda
NCT07571109 Phase 3
Recruiting
AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps...
Condition
Obesity
Enrollment
300 pts
Location
United States, Australia, China
Sponsor
Novo Nordisk A/S
NCT06736574 Phase 3
Recruiting
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With S...
Condition
Heart Failure
Enrollment
1,800 pts
Location
United States, Canada, China
Sponsor
Cytokinetics
NCT07226076 Phase 3
Recruiting
Methadone in TKA for Post-op Pain and Opioid Reduction
Condition
Post Operative Pain
Enrollment
162 pts
Location
United States
Sponsor
Medical University of South Ca
NCT06672497 N/A
Recruiting
Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity o...
Condition
Breast Cancer
Enrollment
30 pts
Location
United States
Sponsor
University of South Carolina
NCT07339423 Phase 3
Recruiting
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps...
Condition
Obesity
Enrollment
1,150 pts
Location
United States, Argentina, Australia
Sponsor
Novo Nordisk A/S
NCT06425848 N/A
Recruiting
HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
Condition
Heart Failure
Enrollment
2,000 pts
Location
United States
Sponsor
University of Kansas Medical C
NCT07645248 Phase 3
Recruiting
A Study to Compare Safety of 4 Weeks Exposure to Propellants Hydrofluoroalkane 1...
Condition
Asthma
Enrollment
110 pts
Location
United States, Argentina, Canada
Sponsor
GlaxoSmithKline
NCT05701917 N/A
Recruiting
DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombos...
Condition
Venous Thromboembolism
Enrollment
300 pts
Location
United States, Austria, Finland
Sponsor
Inari Medical
NCT07629440 Phase 3
Recruiting
A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.
Condition
Pneumococcal Disease
Enrollment
3,230 pts
Location
United States, Japan, Puerto Rico
Sponsor
Pfizer
NCT07223840 Phase 2
Recruiting
A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid R...
Condition
Smoking
Enrollment
222 pts
Location
United States, China, Japan
Sponsor
Eli Lilly and Company
NCT07287150 Phase 2
Recruiting
A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-...
Condition
Metastatic Castration-Resistant Prostate Cancer
Enrollment
100 pts
Location
United States, Australia, Brazil
Sponsor
Hoffmann-La Roche
NCT07574593 N/A
Recruiting
NORM-HF Pivotal Study
Condition
Heart Failure
Enrollment
800 pts
Location
United States
Sponsor
Foundry Innovation & Research
NCT06030063 N/A
Recruiting
The Society for Obstetric Anesthesia and Perinatology Research Network General A...
Condition
Cesarean Delivery
Enrollment
5,000 pts
Location
United States, Canada
Sponsor
Yale University
NCT06747117 N/A
Recruiting
A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus ...
Condition
Lower Extremity Acute Limb Ischemia
Enrollment
300 pts
Location
United States, Australia, Brazil
Sponsor
Penumbra Inc.
NCT06628908 Phase 3
Recruiting
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabet...
Condition
Diabetic Peripheral Neuropathic Pain
Enrollment
1,100 pts
Location
United States
Sponsor
Vertex Pharmaceuticals Incorpo
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology