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Medical Condition

opioid use disorder

Total Trials

26

Recruiting Now

26

Trial Phases

Phase 4, Phase 2, Phase 3

ClinicalMetric tracks all active clinical trials for opioid use disorder sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — opioid use disorder Clinical Trials

How many clinical trials are currently recruiting for opioid use disorder?

ClinicalMetric currently tracks 26 actively recruiting clinical trials for opioid use disorder, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 26. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for opioid use disorder?

opioid use disorder research spans Phase 1 (1 trial), Phase 2 (4 trials), Phase 3 (2 trials), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a opioid use disorder clinical trial?

Eligibility criteria for opioid use disorder trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

1

Phase 2

4

Phase 3

2

Phase 4

3

Top Sponsors

NYU Langone Health 2 trials

Friends Research Institute, Inc. 2 trials

Medical University of South Carolina 2 trials

Boston Medical Center 2 trials

Neurotype Inc. 1 trial

Recruiting Clinical Trials

Brain Training for Substance Use Disorders

HIV, Equity, and Addiction Training (HEAT) Program

University of Alabama at Birmi...

NCT04811014 Phase 4

Young Houston Emergency Opioid Engagement System

The University of Texas Health...

NCT06441604 Phase 2

Extended-release Buprenorphine as a Novel Low-dose Induction Strategy

Brigham and Women's Hospital

NCT05834478 Phase 3

Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

Emory University

NCT06796062 Phase 2

Psilocybin for Opioid Use Disorder (OUD)

NYU Langone Health

NavSTAR Implementation Effectiveness Trial Across a Health System

Friends Research Institute, In...

LIFU for Treatment for Refractory Opioid Use Disorder

Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

University of Washington

Using AI and Peer Coaching to Address Racial Disparities Among People Who Use Opioids

Friends Research Institute, In...

Social Functioning in Opioid Use Disorder

Medical University of South Ca...

Infectious Disease (ID) Testing OUtreach in Carceral Hubs

Boston Medical Center

NCT07169409 Phase 1

Right Tools, Right Time, Right Place: Telehealth for Opioid Use Disorder in Vulnerable Settings

NCT07439549 Phase 4

Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility Trial

NCT06067737 Phase 2

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

Johns Hopkins University

NCT05033028 Phase 3

Smartphones for Opiate Addiction Recovery

NYU Langone Health

Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

Yale University

OUD (Opioid Use Disorder) Target Trial

Duke University

PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

Boston Medical Center

Low-Intensity Focused Ultrasound and the Complex Patient

Virginia Polytechnic Institute...

NCT05027919 Phase 2

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

University of Maryland, Baltim...

Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD

Ohio State University

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

Wake Forest University Health ...

NCT06880718 Phase 4

Injectable Buprenorphine in Prison: A Preference Trial

Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder

Prisma Health-Upstate

Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD

Medical University of South Ca...

Related Conditions

opioid use (4) substance use disorders (2) hiv (1) stimulant use diagnosis (1) opioid dependence (1) opioid overdose (1) withdrawal symptoms (1) hiv infections (1) ocd (1) major depressive disorder mdd (1) alcohol use disorder aud (1) healthy volunteer (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology