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opioid use disorder

Total Trials
20
Recruiting Now
20
Trial Phases
Phase 2, Phase 1, Phase 3

ClinicalMetric tracks all active clinical trials for opioid use disorder sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — opioid use disorder Clinical Trials

How many clinical trials are currently recruiting for opioid use disorder?
ClinicalMetric currently tracks 20 actively recruiting clinical trials for opioid use disorder, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 20. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for opioid use disorder?
opioid use disorder research spans Phase 1 (1 trial), Phase 2 (2 trials), Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a opioid use disorder clinical trial?
Eligibility criteria for opioid use disorder trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
1
Phase 2
2
Phase 3
1
Top Sponsors
University of Alabama at Birmingham 2 trials
Wake Forest University Health Sciences 1 trial
University of Maryland, Baltimore 1 trial
Brigham and Women's Hospital 1 trial
Rutgers, The State University of New Jersey 1 trial

Recruiting Clinical Trials

NCT04927143
Recruiting
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Enrollment
600 pts
Location
United States
Sponsor
Wake Forest University Health ...
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NCT05511909 Phase 2
Recruiting
Evaluating Buspirone to Treat Opioid Withdrawal
Enrollment
100 pts
Location
United States
Sponsor
University of Maryland, Baltim...
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NCT06639464 Phase 2
Recruiting
Semaglutide for Helping Opioid Recovery
Enrollment
46 pts
Location
United States
Sponsor
Brigham and Women's Hospital
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NCT06642181 Phase 1
Recruiting
Combined Guanfacine and Mindfulness Meditation as an Adjunct to Buprenorphine Maintenance in Opioid Use Disorder
Enrollment
224 pts
Location
United States
Sponsor
Rutgers, The State University ...
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NCT07129902
Recruiting
Contingency Management to Improve Medication for Opioid Use Disorder Continuation After the Emergency Department
Enrollment
30 pts
Location
United States
Sponsor
University of Vermont
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NCT06870110
Recruiting
Brain Training for Substance Use Disorders
Enrollment
40 pts
Location
United States
Sponsor
Neurotype Inc.
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NCT04978168
Recruiting
Opioid Treatment and Peer Recovery Support
Enrollment
450 pts
Location
United States
Sponsor
Brown University
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NCT06355778
Recruiting
Adversity, Brain and Opioid Use Study
Enrollment
185 pts
Location
United States
Sponsor
University of Michigan
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NCT06513156
Recruiting
Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use
Enrollment
304 pts
Location
United States
Sponsor
Elana Rosenthal
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NCT06494904 Phase 3
Recruiting
Standard Versus High Dose ED-Initiated Buprenorphine Induction
Enrollment
360 pts
Location
United States
Sponsor
Yale University
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NCT07610746
Recruiting
Cerebral Physiology of NOWS
Enrollment
46 pts
Location
United States
Sponsor
Indiana University
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NCT05995886
Recruiting
Using Facebook to Support Opioid Recovery Among American Indian Women
Enrollment
60 pts
Location
United States
Sponsor
Mayo Clinic
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NCT06487533
Recruiting
Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
Enrollment
20 pts
Location
United States
Sponsor
Spark Biomedical, Inc.
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NCT07044466
Recruiting
Social Functioning in Opioid Use Disorder
Enrollment
230 pts
Location
United States
Sponsor
Medical University of South Ca...
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NCT07232641
Recruiting
Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic
Enrollment
185,810 pts
Location
United States
Sponsor
Boston University
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NCT06370481
Recruiting
HIV, Equity, and Addiction Training (HEAT) Program
Enrollment
30 pts
Location
United States
Sponsor
University of Alabama at Birmi...
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NCT06696157
Recruiting
EXPANDED SCOPE for Parent Grant Entitled, "Peer Recovery Support Services for Individuals in Recovery Residences on MOUD"
Enrollment
35 pts
Location
United States
Sponsor
Potomac Health Foundations
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NCT07631598
Recruiting
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
Enrollment
512 pts
Location
United States
Sponsor
Montefiore Medical Center
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NCT06565416
Recruiting
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
Enrollment
225 pts
Location
United States
Sponsor
University of New Mexico
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NCT06104280
Recruiting
Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment
Enrollment
200 pts
Location
United States
Sponsor
University of Alabama at Birmi...
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Related Conditions

opioid withdrawal (2) substance use disorders (2) cocaine use disorder (1) opioid use (1) cocaine use (1) substance use (1) methamphetamine abuse (1) methamphetamine dependence (1) opioid craving (1) anxiety (1) mindfulness (1) guanfacine (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: September 2026  ·  Data Methodology