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Medical Condition

opioid use disorder

Total Trials

27

Recruiting Now

27

Trial Phases

Phase 4, Phase 2, Phase 3

ClinicalMetric tracks all active clinical trials for opioid use disorder sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — opioid use disorder Clinical Trials

How many clinical trials are currently recruiting for opioid use disorder?

ClinicalMetric currently tracks 27 actively recruiting clinical trials for opioid use disorder, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 27. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for opioid use disorder?

opioid use disorder research spans Phase 1 (1 trial), Phase 2 (4 trials), Phase 3 (3 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a opioid use disorder clinical trial?

Eligibility criteria for opioid use disorder trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

1

Phase 2

4

Phase 3

3

Phase 4

1

Top Sponsors

University of Pennsylvania 3 trials

Friends Research Institute, Inc. 2 trials

Medical University of South Carolina 2 trials

University of Connecticut 1 trial

Baylor College of Medicine 1 trial

Recruiting Clinical Trials

NCT05669534 Phase 4

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

University of Connecticut

Cortical rTMS as a Treatment for Depression

Baylor College of Medicine

Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

Stony Brook University

Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

Boston University

NCT07369089 Phase 2

Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement

University of California, San ...

Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD

Ohio State University

NCT05589181 Phase 3

High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED)

Rutgers, The State University ...

Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

Friends Research Institute, In...

An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

University of Pennsylvania

NCT04893525 Phase 2, Phase 3

Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments

University of British Columbia

NCT05729932 Phase 1

Cannabis and Opioid Use Disorder

Shanna Babalonis, PhD

NavSTAR Implementation Effectiveness Trial Across a Health System

Friends Research Institute, In...

Integrating Brain, Neurocognitive, and Computational Tools in OUD

University of Pennsylvania

Evaluation of a Physical Device for Medical Use (ADTPM 1) for Opioid Withdrawal Symptoms

Nu Eyne Co., Ltd.

Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid Use Disorder in Durham, North Carolina

Duke University

Project I Test: Implementing HIV Testing in Opioid Treatment Programs

Columbia University

Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

Senthil Sadhasivam

Optimization of NIBS for Treatment of Addiction

Case Western Reserve Universit...

Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD

Medical University of South Ca...

The Youth Opioid Recovery Support (YORS) Intervention

Potomac Health Foundations

Autobiographical Memory in Opioid Use Disorder

University of Pennsylvania

NCT06338280 Phase 2

Remotely Observed Methadone Evaluation II

Social Functioning in Opioid Use Disorder

Medical University of South Ca...

Focused Ultrasound for the Complex Patient

Washington D.C. Veterans Affai...

Integrating MOUD in Nonmedical Community Settings (Better Together)

Howard University

NCT05011266 Phase 2, Phase 3

Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder

New York State Psychiatric Ins...

Translation and Validation of the COMM and ASI-SR

Uppsala University

Related Conditions

substance use disorders (2) alcohol use disorder (2) hiv (1) major depressive disorder (1) suicidality (1) parent child relations (1) neonatal abstinence syndrome (1) opioid withdrawal disorder (1) digital health intervention (1) telemedicine (1) outreach intervention (1) hiv aids (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology