State PA
Clinical Trials in Pennsylvania
Pennsylvania is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Pennsylvania and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 481 actively recruiting studies with Pennsylvania sites out of 481 registered in total. The busiest research areas in Pennsylvania are Breast Cancer, Acute Myeloid Leukemia, Ovarian Cancer. Leading sponsors running trials in the state include University of Pennsylvania, University of Pittsburgh, National Cancer Institute (NCI). By stage, Pennsylvania trials break down as Phase 1 (77), Phase 2 (124), Phase 3 (115), Phase 4 (15).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Pennsylvania
Frequently Asked Questions — Clinical Trials in Pennsylvania
How many clinical trials are currently recruiting in Pennsylvania?
ClinicalMetric currently tracks 481 actively recruiting clinical trials with at least one location in Pennsylvania. The total number of registered studies—including active but not currently enrolling trials—is 481. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Pennsylvania?
Pennsylvania hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Acute Myeloid Leukemia, Ovarian Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Pennsylvania serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Pennsylvania?
To join a clinical trial in Pennsylvania, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Pennsylvania maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Pennsylvania
NCT06377033 N/A
Recruiting
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Condition
Genetic Predisposition
Enrollment
1,000 pts
Location
United States
Sponsor
University of Pennsylvania
NCT05429632 Phase 3
Recruiting
Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Al...
Condition
Adult Acute Myeloid Leukemia
Enrollment
366 pts
Location
United States, Argentina, Brazil
Sponsor
Priothera SAS
NCT06401421 N/A
Recruiting
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Brea...
Condition
Breast Cancer
Enrollment
1,800 pts
Location
United States, Canada
Sponsor
Exact Sciences Corporation
NCT06502171 Phase 1
Recruiting
Study of Cabozantinib With Selumetinib for Plexiform Neurofibromas
Condition
Neurofibromatosis 1
Enrollment
30 pts
Location
United States
Sponsor
Girish Dhall, MD
NCT05267821 Phase 2, Phase 3
Recruiting
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
Condition
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
Enrollment
500 pts
Location
United States
Sponsor
Nationwide Children's Hospital
NCT06568367 Phase 3
Recruiting
Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shif...
Condition
Excessive Sleepiness
Enrollment
520 pts
Location
United States, Canada
Sponsor
Axsome Therapeutics, Inc.
NCT06050707 Phase 2
Recruiting
MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk...
Condition
Anal Squamous Cell Carcinoma
Enrollment
80 pts
Location
United States, Australia, Canada
Sponsor
University Health Network, Tor
NCT06817863 Phase 1, Phase 2
Recruiting
A Self-Guided Mobile Intervention for Adults With Binge Eating and Obesity
Condition
Binge Eating Disorder Associated With Obesity
Enrollment
30 pts
Location
United States
Sponsor
Drexel University
NCT06909565 Phase 4
Recruiting
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and...
Condition
Percutaneous Coronary Intervention
Enrollment
6,000 pts
Location
United States
Sponsor
Duke University
NCT01587300 N/A
Recruiting
Neuroblastoma Biology Study
Condition
Neuroblastoma
Enrollment
1,000 pts
Location
United States, Canada
Sponsor
New Approaches to Neuroblastom
NCT06950099 N/A
Recruiting
Advanced Neuroimaging in Idiopathic Intracranial Hypertension
Condition
Idiopathic Intracranial Hypertension (IIH)
Enrollment
30 pts
Location
United States
Sponsor
Thomas Jefferson University
NCT07496567 Phase 2, Phase 3
Recruiting
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-...
Condition
Macular Degeneration
Enrollment
960 pts
Location
United States, Brazil, Colombia
Sponsor
EyeBiotech Ltd.
NCT05919511 N/A
Recruiting
Observational Study for Patients at Risk for Chronic Graft-Versus-Host Disease
Condition
cGVHD
Enrollment
1,500 pts
Location
United States
Sponsor
Incyte Corporation
NCT07598825 Phase 3
Recruiting
A Trial of Inebilizumab in Participants With Autoimmune Hepatitis
Condition
Autoimmune Hepatitis
Enrollment
180 pts
Location
United States, Belgium, Canada
Sponsor
Amgen
NCT04380740 Phase 2
Recruiting
Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxi...
Condition
Graft Vs Host Disease
Enrollment
160 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT05714085 Phase 2, Phase 3
Recruiting
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants W...
Condition
Heart Failure
Enrollment
342 pts
Location
United States, Belgium, Brazil
Sponsor
Merck Sharp & Dohme LLC
NCT05875155 N/A
Recruiting
Ovarian Tissue Cryopreservation for Fertility Preservation
Condition
Cancer
Enrollment
500 pts
Location
United States
Sponsor
University of Pittsburgh
NCT05642455 Phase 1, Phase 2
Recruiting
SPEARHEAD-3 Pediatric Study
Condition
Synovial Sarcoma
Enrollment
20 pts
Location
United States
Sponsor
USWM CT, LLC
NCT06731478 Phase 3
Recruiting
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metast...
Condition
Gastric Cancer
Enrollment
726 pts
Location
United States, Argentina, Australia
Sponsor
Daiichi Sankyo
NCT05937594 N/A
Recruiting
MicroRNA Biomarkers for Neonatal Opioid Withdrawal Syndrome
Condition
Neonatal Opioid Withdrawal Syndrome
Enrollment
50 pts
Location
United States
Sponsor
Milton S. Hershey Medical Cent
NCT05871970 Phase 2
Recruiting
Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic...
Condition
Lymphatic Malformation
Enrollment
38 pts
Location
United States
Sponsor
Protara Therapeutics
NCT05359562 N/A
Recruiting
How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of Pe...
Condition
OCD
Enrollment
120 pts
Location
United States
Sponsor
University of Pennsylvania
NCT07469605 N/A
Recruiting
Hysteroscopy for the Diagnosis and Treatment of Pregnancy of Unknown Location
Condition
Pregnancy of Unknown Location
Enrollment
60 pts
Location
United States
Sponsor
University of Pennsylvania
NCT05008146 EARLY_Phase 1
Recruiting
Imaging CRF X NOP Interactions in CUD
Condition
Cocaine Use Disorder
Enrollment
80 pts
Location
United States
Sponsor
Rajesh Narendran
NCT02939573 Phase 2
Recruiting
A Randomized Multicenter Study for Isolated Skin Vasculitis
Condition
Primary Cutaneous Vasculitis
Enrollment
90 pts
Location
United States, Canada, Japan
Sponsor
University of Pennsylvania
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology