State MO
Clinical Trials in Missouri
Missouri is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Missouri and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 275 actively recruiting studies with Missouri sites out of 275 registered in total. The busiest research areas in Missouri are Obesity, Heart Failure, Multiple Myeloma. Leading sponsors running trials in the state include Washington University School of Medicine, National Cancer Institute (NCI), AstraZeneca. By stage, Missouri trials break down as Phase 1 (52), Phase 2 (71), Phase 3 (78), Phase 4 (10).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Missouri
Frequently Asked Questions — Clinical Trials in Missouri
How many clinical trials are currently recruiting in Missouri?
ClinicalMetric currently tracks 275 actively recruiting clinical trials with at least one location in Missouri. The total number of registered studies—including active but not currently enrolling trials—is 275. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Missouri?
Missouri hosts clinical trials across a broad range of medical conditions, including Obesity, Heart Failure, Multiple Myeloma, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Missouri serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Missouri?
To join a clinical trial in Missouri, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Missouri maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Missouri
NCT07285213 Phase 2
Recruiting
Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Ant...
Condition
Clostridioides Difficile Infection
Enrollment
230 pts
Location
United States, Australia, Canada
Sponsor
AstraZeneca
NCT06843317 Phase 1
Recruiting
Safety and Immunogenicity Study of Revaccination With SCB-1019T in Healthy Adult...
Condition
RSV Infection
Enrollment
160 pts
Location
United States
Sponsor
Clover Biopharmaceuticals USA,
NCT06131840 Phase 1
Recruiting
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
Condition
Colorectal Neoplasms
Enrollment
914 pts
Location
United States, Canada, China
Sponsor
Seagen, a wholly owned subsidi
NCT06890676 N/A
Recruiting
Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and I...
Condition
Periodontitis
Enrollment
150 pts
Location
United States
Sponsor
Missouri Department of Health
NCT07645287 Phase 2
Recruiting
A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologica...
Condition
HIV-1-infection
Enrollment
175 pts
Location
United States, Australia, Canada
Sponsor
Gilead Sciences
NCT05462106 Phase 1, Phase 2
Recruiting
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down S...
Condition
Amyloid Plaque
Enrollment
304 pts
Location
United States, Spain, United Kingdom
Sponsor
AC Immune SA
NCT07218133 N/A
Recruiting
Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery
Condition
Spinal Fusion
Enrollment
50 pts
Location
United States
Sponsor
Alexander T. Yahanda
NCT06969235 N/A
Recruiting
Examining the Role of Executive Functioning in Family-Based Intensive Health Beh...
Condition
Pediatric Overweight
Enrollment
10 pts
Location
United States
Sponsor
University of Missouri-Columbi
NCT05743283 N/A
Recruiting
Efficacy of SynEx Wound Rinse in Civilian Surrogates of Combat Injury Wounds
Condition
Wound Heal
Enrollment
100 pts
Location
United States
Sponsor
Synedgen, Inc.
NCT07226661 Phase 2
Recruiting
Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
Condition
Major Depressive Disorder (MDD)
Enrollment
230 pts
Location
United States
Sponsor
Supernus Pharmaceuticals, Inc.
NCT07689162 Phase 2
Recruiting
Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia
Condition
Pain, Postoperative
Enrollment
45 pts
Location
United States
Sponsor
Washington University School o
NCT05187182 Phase 1
Recruiting
CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated ...
Condition
Gastric Cancer
Enrollment
42 pts
Location
United States
Sponsor
Washington University School o
NCT07037459 Phase 3
Recruiting
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejecti...
Condition
Heart Failure With Preserved Ejection Fraction
Enrollment
5,056 pts
Location
United States, Argentina, Australia
Sponsor
Amgen
NCT06959524 N/A
Recruiting
AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Co...
Condition
Coronary Arterial Disease (CAD)
Enrollment
1,616 pts
Location
United States, Australia, China
Sponsor
Boston Scientific Corporation
NCT07441694 Phase 1
Recruiting
Study of INCA036978 in Participants With Myeloproliferative Neoplasms
Condition
Myeloproliferative Neoplasms
Enrollment
218 pts
Location
United States, Australia, Belgium
Sponsor
Incyte Corporation
NCT07355062 Phase 3
Recruiting
A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Me...
Condition
CKD
Enrollment
150 pts
Location
United States
Sponsor
Renibus Therapeutics, Inc.
NCT07504588 Phase 2
Recruiting
Sacituzumab Govitecan With Bevacizumab Compared to Usual Chemotherapy (Carboplat...
Condition
Recurrent Platinum-Sensitive Fallopian Tube Endometrioid Adenocarcinoma
Enrollment
87 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT05431088 Phase 2, Phase 3
Recruiting
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Condition
Sickle Cell Disease
Enrollment
389 pts
Location
United States, Brazil, India
Sponsor
Pfizer
NCT06835569 Phase 1
Recruiting
A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tum...
Condition
Cancer
Enrollment
448 pts
Location
United States
Sponsor
Alterome Therapeutics, Inc.
NCT07910266 Phase 4
Recruiting
Impact of Egg-Based and Cell-Based Vaccine Platforms on Immune Responses to Repe...
Condition
Immunology
Enrollment
220 pts
Location
United States
Sponsor
University of Missouri-Columbi
NCT06001827 N/A
Recruiting
SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study
Condition
Chronic Kidney Diseases
Enrollment
600 pts
Location
United States
Sponsor
VenoStent
NCT02422641 Phase 2
Recruiting
Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breas...
Condition
Metastatic Breast Cancer
Enrollment
16 pts
Location
United States
Sponsor
Wake Forest University Health
NCT03876054 N/A
Recruiting
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
Condition
Chronic Pain
Enrollment
2,000 pts
Location
United States, Australia, Belgium
Sponsor
Abbott Medical Devices
NCT06240754 Phase 2
Recruiting
Enasidenib for Patients With Clonal Cytopenia of Undetermined Significance and M...
Condition
Clonal Cytopenia of Undetermined Significance
Enrollment
15 pts
Location
United States
Sponsor
Washington University School o
NCT06860594 Phase 1
Recruiting
Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Th...
Condition
Astrocytoma, IDH-Mutant, Grade 2
Enrollment
30 pts
Location
United States
Sponsor
National Cancer Institute (NCI
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology