State MA
Clinical Trials in Massachusetts
Massachusetts is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Massachusetts and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 474 actively recruiting studies with Massachusetts sites out of 474 registered in total. The busiest research areas in Massachusetts are Prostate Cancer, Colorectal Cancer, Breast Cancer. Leading sponsors running trials in the state include Massachusetts General Hospital, Brigham and Women's Hospital, Boston Children's Hospital. By stage, Massachusetts trials break down as Phase 1 (86), Phase 2 (125), Phase 3 (78), Phase 4 (14).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Massachusetts
Frequently Asked Questions — Clinical Trials in Massachusetts
How many clinical trials are currently recruiting in Massachusetts?
ClinicalMetric currently tracks 474 actively recruiting clinical trials with at least one location in Massachusetts. The total number of registered studies—including active but not currently enrolling trials—is 474. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Massachusetts?
Massachusetts hosts clinical trials across a broad range of medical conditions, including Prostate Cancer, Colorectal Cancer, Breast Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Massachusetts serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Massachusetts?
To join a clinical trial in Massachusetts, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Massachusetts maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Massachusetts
NCT03471260 Phase 1, Phase 2
Recruiting
Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With ...
Condition
Acute Myeloid Leukemia
Enrollment
96 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
NCT05096715 Phase 1
Recruiting
Atezolizumab+Bevacizumab+SBRT in Unresectable HCC
Condition
Unresectable Hepatocellular Carcinoma
Enrollment
20 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT06312176 Phase 3
Recruiting
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combinatio...
Condition
Breast Neoplasms
Enrollment
1,200 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
NCT06994676 Phase 1
Recruiting
A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias
Condition
High-risk Myelodysplastic Syndrome
Enrollment
72 pts
Location
United States
Sponsor
Crossbow Therapeutics, Inc.
NCT07108387 Phase 2
Recruiting
Tocilizumab Discontinuation Versus Dose Reduction for Patients With Well-Control...
Condition
Giant Cell Arteritis (GCA)
Enrollment
78 pts
Location
United States
Sponsor
National Institute of Allergy
NCT07574593 N/A
Recruiting
NORM-HF Pivotal Study
Condition
Heart Failure
Enrollment
800 pts
Location
United States
Sponsor
Foundry Innovation & Research
NCT07146516 N/A
Recruiting
Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)
Condition
Stickler Syndrome Type 1
Enrollment
500 pts
Location
United States
Sponsor
Helen Keller Eye Research Foun
NCT06030063 N/A
Recruiting
The Society for Obstetric Anesthesia and Perinatology Research Network General A...
Condition
Cesarean Delivery
Enrollment
5,000 pts
Location
United States, Canada
Sponsor
Yale University
NCT07208916 N/A
Recruiting
Evaluation of the Potential of Grape Consumption to Improve Muscle Strength and ...
Condition
Healthy
Enrollment
35 pts
Location
United States
Sponsor
Western New England University
NCT00009633 N/A
Recruiting
Follow-up Visit of High Risk Infants
Condition
Infant, Newborn
Enrollment
68,000 pts
Location
United States
Sponsor
NICHD Neonatal Research Networ
NCT05839535 Phase 2
Recruiting
Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA
Condition
Knee Osteoarthritis
Enrollment
140 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT07232043 N/A
Recruiting
ACTIVATE: AI-driven Clinical-trial Trial-Information and Viability Assessment To...
Condition
Cancer
Enrollment
70,000 pts
Location
United States
Sponsor
Dana-Farber Cancer Institute
NCT01858285 N/A
Recruiting
Genetics of Epilepsy and Related Disorders
Condition
Epilepsy
Enrollment
5,000 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT06747117 N/A
Recruiting
A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus ...
Condition
Lower Extremity Acute Limb Ischemia
Enrollment
300 pts
Location
United States, Australia, Brazil
Sponsor
Penumbra Inc.
NCT05356117 N/A
Recruiting
Resistance Exercise Combined With Protein Supplementation in People With Pancrea...
Condition
Pancreatic Cancer
Enrollment
45 pts
Location
United States
Sponsor
Dana-Farber Cancer Institute
NCT04759443 N/A
Recruiting
Detection of Small Fiber Neuropathy Using Skin Properties
Condition
Small Fiber Neuropathy
Enrollment
400 pts
Location
United States
Sponsor
Brigham and Women's Hospital
NCT06628908 Phase 3
Recruiting
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabet...
Condition
Diabetic Peripheral Neuropathic Pain
Enrollment
1,100 pts
Location
United States
Sponsor
Vertex Pharmaceuticals Incorpo
NCT06821568 N/A
Recruiting
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
Condition
Alzheimer Disease and Related Dementias
Enrollment
128 pts
Location
United States, Israel
Sponsor
Hebrew SeniorLife
NCT04792489 Phase 2
Recruiting
DALY II USA/ MB-CART2019.1 for DLBCL
Condition
Refractory Diffuse Large B Cell Lymphoma (DLBCL)
Enrollment
315 pts
Location
United States, Canada
Sponsor
Miltenyi Biomedicine GmbH
NCT05475925 Phase 1, Phase 2
Recruiting
A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotox...
Condition
LGLL - Large Granular Lymphocytic Leukemia
Enrollment
200 pts
Location
United States, Australia, France
Sponsor
Dren Bio
NCT06902376 Phase 1
Recruiting
XL092 and Cemiplimab in BRAF WT Thyroid Cancer
Condition
Anaplastic Thyroid Cancer
Enrollment
12 pts
Location
United States
Sponsor
UNC Lineberger Comprehensive C
NCT07502989 N/A
Recruiting
Muscle Health Measurements Using Electrical Impedance Myography
Condition
Myopathy
Enrollment
150 pts
Location
United States
Sponsor
Beth Israel Deaconess Medical
NCT06462235 Phase 2
Recruiting
A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infan...
Condition
Gram-negative Bacterial Infection
Enrollment
48 pts
Location
United States, Argentina, Bulgaria
Sponsor
Pfizer
NCT06323447 N/A
Recruiting
Pivotal Study to Validate a Novel System to Non-Invasively Detect Severe Neutrop...
Condition
Diffuse Large B Cell Lymphoma
Enrollment
210 pts
Location
United States, Spain
Sponsor
Leuko Labs, Inc.
NCT03178149 Phase 1
Recruiting
A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losin...
Condition
Age-Related Macular Degeneration
Enrollment
42 pts
Location
United States
Sponsor
Astellas Institute for Regener
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology