Medical Condition

depression

Total Trials

20

Recruiting Now

20

Trial Phases

Phase 1, Phase 4, Phase 2

Depression trials address major depressive disorder (MDD), treatment-resistant depression (TRD), and postpartum depression with a growing toolkit that extends beyond conventional SSRIs/SNRIs. The rapid approval of ketamine/esketamine for TRD has sparked interest in NMDA receptor modulators, while psychedelic-assisted therapy (psilocybin, MDMA) trials represent a paradigm shift in psychiatric research.

Active trials investigate rapid-acting antidepressants (ketamine analogs), neuroactive steroids, transcranial magnetic stimulation (TMS) protocols, psychedelic-assisted psychotherapy, digital therapeutics, and precision psychiatry approaches using biomarkers or genetic testing to predict treatment response.

Depression trials typically require a minimum MADRS or HAMD score at baseline; TRD trials usually require failure of at least 2 prior adequate antidepressant courses.

Frequently Asked Questions — depression Clinical Trials

How many clinical trials are currently recruiting for depression?

ClinicalMetric currently tracks 20 actively recruiting clinical trials for depression, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 20. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for depression?

depression research spans Phase 1 (1 trial), Phase 2 (1 trial), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a depression clinical trial?

Eligibility criteria for depression trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 4

Top Sponsors

Weill Medical College of Cornell University 1 trial

University of Pittsburgh 1 trial

Virginia Commonwealth University 1 trial

Mayo Clinic 1 trial

Lindsay Maguire, MD 1 trial

depression

Frequently Asked Questions — depression Clinical Trials

Recruiting Clinical Trials

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

Parent Encouragement And Coaching of Happiness in Youth

Mindful Moms Randomized Control Trial

Effect of Vagal Nerve Stimulation on Gastric Motor Functions

Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

Impact of Depression on Thermoregulation

Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)

Effects of an ACT-based Psychological Treatment in Patients With Chronic Kidney Disease

Neurodevelopmental Outcomes in Children: Strengthening the Caregiver-Child Story

A Randomized Controlled Study of Digitalized Cognitive Behavioral Intervention for Antenatal Depression

Developing Resilience and Anxiety Management Through the Arts

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction

Implementation of DWM in Dutch SMEs

RCT for Latina Mental Health Using Web-Based Apps

fMRI Neurofeedback With Matter Neuroscience App

Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression

Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons

Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

Depression, Aging, Stress and Heart Health Study