Browse by Phase
Phase 4 Clinical Trials
Phase 4 trials (post-market surveillance) occur after a drug has been approved. They monitor long-term effectiveness and safety in general patient populations.
Total Trials
350
Recruiting Now
350
Top Conditions in Phase 4
Frequently Asked Questions — Phase 4 Trials
What is the purpose of a Phase 4 post-market clinical trial?
Phase 4 trials occur after a drug has received regulatory approval. They monitor long-term effectiveness and safety in real-world patient populations, detect rare adverse events too infrequent to appear in earlier trials, study effectiveness in subgroups (elderly, pediatric, renally impaired), and may explore new indications for the approved drug. Some Phase 4 studies are mandated by the FDA as a condition of approval.
Who sponsors Phase 4 trials?
Phase 4 trials are primarily sponsored by pharmaceutical and biotech companies that hold the drug's marketing authorization. Some are mandated by the FDA or EMA—particularly when approval was based on surrogate endpoints and confirmatory long-term data is required. Independent academic institutions and registry-based programs also conduct Phase 4 studies.
Are Phase 4 trials safer than Phase 1–3 trials?
Phase 4 trials involve drugs that have already demonstrated an acceptable safety profile in earlier phases and received regulatory approval. As a result, the risk profile for participants is generally better characterized than in early-phase trials. However, these studies are still clinical research designed partly to detect long-term or rare adverse events not observed in pre-approval trials.
Active Phase 4 Studies
NCT06824103 Phase 4
Recruiting
Study of Efficacy and Safety of Ruxolitinib in Chinese Participants With Cortico...
Condition
Graft vs. Host Disease
Enrollment
50 pts
Location
China
Sponsor
Novartis Pharmaceuticals
NCT06603662 Phase 4
Recruiting
Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in ...
Condition
Osteoarthritis
Enrollment
192 pts
Location
United States
Sponsor
WellSpan Health
NCT06528873 Phase 4
Recruiting
COMS for Chronic Ulcers Treatment
Condition
Venous Leg Ulcer
Enrollment
122 pts
Location
Austria, France, Germany
Sponsor
Sebastian Probst
NCT05780905 Phase 4
Recruiting
Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability...
Condition
Diabetes Mellitus, Type 2
Enrollment
50 pts
Location
United States
Sponsor
University of Washington
NCT06112353 Phase 4
Recruiting
Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection
Condition
Intestinal Disease
Enrollment
128 pts
Location
United States
Sponsor
University of California, Irvi
NCT05023369 Phase 4
Recruiting
This is a Study to Verify if Periarticular Hip Injection of Corticosteroid After...
Condition
Femoral Neck Fractures
Enrollment
110 pts
Location
Switzerland
Sponsor
Ente Ospedaliero Cantonale, Be
NCT06291077 Phase 4
Recruiting
Comparison of the Effects of Belatacept and Anticalcineurins on Endothelial Func...
Condition
Kidney Diseases
Enrollment
44 pts
Location
France
Sponsor
University Hospital, Rouen
NCT05853627 Phase 4
Recruiting
Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With P...
Condition
Stress Disorders, Post-Traumatic
Enrollment
80 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT07308756 Phase 4
Recruiting
Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality ...
Condition
General Anesthesia
Enrollment
316 pts
Location
China
Sponsor
Peking University First Hospit
NCT07209475 Phase 4
Recruiting
Effect of Amnio-Maxx on the Healing Rate of Chronic Diabetic Foot Ulcers.
Condition
Diabetic Foot Ulcer (DFU)
Enrollment
248 pts
Location
United States
Sponsor
Royal Biologics
NCT05640453 Phase 4
Recruiting
Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery B...
Condition
Pregabalin
Enrollment
70 pts
Location
Egypt
Sponsor
Tanta University
NCT06624696 Phase 4
Recruiting
Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Ch...
Condition
Respiratory Hypersensitivity
Enrollment
204 pts
Location
China
Sponsor
Sun Yat-sen University
NCT05675527 Phase 4
Recruiting
PRP for Glenohumeral Osteoarthritis
Condition
Shoulder Osteoarthritis
Enrollment
135 pts
Location
United States
Sponsor
Hospital for Special Surgery,
NCT05303805 Phase 4
Recruiting
Topical Sevoflurane for Treatment of Chronic Leg Ulcers
Condition
Leg Ulcer
Enrollment
50 pts
Location
Czechia
Sponsor
Charles University, Czech Repu
NCT06320041 Phase 4
Recruiting
Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Ortho...
Condition
Postoperative Pain
Enrollment
162 pts
Location
China
Sponsor
The Fourth Affiliated Hospital
NCT01912651 Phase 4
Recruiting
The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconst...
Condition
Facial Defect
Enrollment
300 pts
Location
United States
Sponsor
University of Michigan
NCT07225361 Phase 4
Recruiting
Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis
Condition
Multiple Sclerosis
Enrollment
40 pts
Location
United States
Sponsor
Northwestern University
NCT03971669 Phase 4
Recruiting
Blood Donor CVD 5000
Condition
Risk Reduction
Enrollment
150 pts
Location
United States
Sponsor
University of Maryland, Baltim
NCT05255003 Phase 4
Recruiting
STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-asso...
Condition
Cancer-associated Thrombosis
Enrollment
50 pts
Location
Canada
Sponsor
Tzu-Fei Wang
NCT06622603 Phase 4
Recruiting
the Effects of Febuxostat Dose Tapering in Gout Patients Optimally Controlled fo...
Condition
Gout
Enrollment
59 pts
Location
South Korea
Sponsor
Seoul National University Hosp
NCT07088146 Phase 4
Recruiting
Dexamethasone in Prolonging the Duration of Spinal Anesthesia Among Pregnant Pat...
Condition
Spinal Anesthesia
Enrollment
110 pts
Location
Pakistan
Sponsor
Rawalpindi Medical College
NCT02283996 Phase 4
Recruiting
Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for U...
Condition
Adhesive Capsulitis
Enrollment
260 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT06455813 Phase 4
Recruiting
What Laxative Should be Used After Hip Fracture Surgery?
Condition
Hip Fractures
Enrollment
375 pts
Location
Denmark
Sponsor
Odense University Hospital
NCT04908423 Phase 4
Recruiting
Xeomin® and Gait Related Mobility After Stroke
Condition
Stroke
Enrollment
20 pts
Location
United States
Sponsor
Wake Forest University Health
NCT04715568 Phase 4
Recruiting
Secondhand Tobacco Smoke and Cardiovascular Disease
Condition
Cardiovascular Diseases
Enrollment
100 pts
Location
United States
Sponsor
University of California, San
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