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type 2 diabetes

Total Trials

36

Recruiting Now

36

Trial Phases

Phase 2, Phase 2, Phase 3, EARLY_Phase 1

Type 2 diabetes trials focus on achieving durable glycemic control while reducing cardiovascular mortality, kidney disease progression, and body weight β€” goals now achievable with newer drug classes that were unavailable a decade ago. The success of GLP-1 receptor agonists and SGLT2 inhibitors in cardiovascular outcome trials has reshaped trial design toward hard endpoint studies.

Active research areas include novel GLP-1 analogs with improved dosing profiles, combination GLP-1/GIP/glucagon triagonists, once-weekly oral formulations, bariatric surgery comparisons, and precision medicine approaches to match patients to optimal drug classes based on genetics, microbiome, or biomarkers.

Trials typically require a confirmed type 2 diagnosis with HbA1c in a specified range; cardiovascular outcome trials often require existing heart disease or high cardiovascular risk.

Frequently Asked Questions — type 2 diabetes Clinical Trials

How many clinical trials are currently recruiting for type 2 diabetes?

ClinicalMetric currently tracks 36 actively recruiting clinical trials for type 2 diabetes, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 36. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for type 2 diabetes?

type 2 diabetes research spans Phase 1 (4 trials), Phase 2 (5 trials), Phase 3 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a type 2 diabetes clinical trial?

Eligibility criteria for type 2 diabetes trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

4

Phase 2

5

Phase 3

3

Top Sponsors

Rutgers, The State University of New Jersey 3 trials

University of Illinois at Chicago 2 trials

Wageningen University 1 trial

Ankara Medipol University 1 trial

Odense University Hospital 1 trial

Recruiting Clinical Trials

Forearm Immobilization in T2D

Wageningen University

Whole Body Vibration Therapy in Individuals With Type 2 Diabetes

Turkey (Türkiye)

Ankara Medipol University

Danish Diabetes Birth Registry 2

Odense University Hospital

Improving Insulin Sensitivity in Patients With Type 2 Diabetes Via Repeated Cold-induced Shivering Thermogenesis

Université de Sherbrooke

Coronary Artery Calcification in Type 2 Diabetes Mellitus (USCAC Study)

University of South China

Multidimensional Accurate Diagnosis and Treatment Technology and Clinical Transformation of Type 2 Diabetes Nephropathy

Chinese PLA General Hospital

Hybrid Closed-Loop for Perioperative Glycemic Control in T2DM With Parenteral Nutrition

Second Xiangya Hospital of Cen...

NCT06727721 Phase 2

Safety and Efficacy of OCN19-overexpressed Human Umbilical Cord-derived Mesenchymal Stem Cells in the Treatment of Refractory Type 2 Diabetes Mellitus

Enhancing Diabetes Care: Exposome &Amp; Sensors

University of Illinois at Chic...

Extracellular Vesicles, Insulin Action, and Exercise

Rutgers, The State University ...

NCT07675499 Phase 2, Phase 3

Exercise and Intranasal Insulin in Type 2 Diabetes

Rutgers, The State University ...

NCT06120881 EARLY_Phase 1

Precision Dosing of Metformin in Youth With T2D

University of California, San ...

NCT07060456 Phase 3

Efficacy and Safety of HRS9531 in Participants With Type 2 Diabetes Treated With Basal Insulin

Fujian Shengdi Pharmaceutical ...

Compilation and Preliminary Application of the Active Health Behavior Scale in Patients With Type 2 Diabetes

NCT07702890 Phase 1, Phase 2

A Three-part First-in-human Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GUB-UCN2 in Healthy Lean and Obese Participants and Participants With T2D

Enhancing Preventative Health Behaviors Among Emergency Department Hyperglycemic Patients

Rutgers, The State University ...

Multicenter, Prospective, Observational Study on the Treatment of Type 2 Diabetes With Proline Plus Empagliflozin Tablets

The Affiliated Nanjing Drum To...

NCT05702463 Phase 1

Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes II

Montreal Heart Institute

Cognitive Bias Modification for Interpretation (CBM-I) in People With Type 2 Diabetes and Persistent Pain

University of Sydney

NCT05345327 Phase 3

SGLT2 Inhibitors As First Line Therapy to Prevent Renal Decline in Type 2 Diabetes

Australia, Sri Lanka

The George Institute

Circadian Intervention to Improve Cardiometabolic Health

University of Utah

The PRECISION-T2D Study: Precision Nutrition Study for Type 2 Diabetes

Westlake University

A Study to Identify the Risk of Non-alcoholic Fatty Liver Disease (NAFLD) in Patients With Type 2 Diabetes in Clinical Practice and to Evaluate the Clinical Usefulness of Dapagliflozin/Pioglitazone Combination Therapy

Boryung Pharmaceutical Co., Lt...

Lactic Acidosis and Prior Metformin Treatment

University Hospital, Strasbour...

Hydroxychloroquine in Type 2 Diabetes During Pregnancy

National University of Malaysi...

Implementation of Team Clinic for Type 2 Diabetes (TCT2)

Children's Hospital Los Angele...

Outcomes of Physiologic Insulin Resensitization (PIR) in Patients With Chronic Kidney Disease and Type 2 Diabetes Mellitus

Well Cell Global

The Next Generation Longitudinal Birth Cohort Diabetes Study

University of Manitoba

DIgitAl diabeTES Treatment - the Healthy Eating, heaLthy Patients Trial

Linkoeping University

NCT07568678 Phase 1

A Phase 1, Multiple Ascending Dose Study to Evaluate HMS1005 in Participants With Type 2 Diabetes

Hua Medicine Limited

NCT06897475 Phase 2

A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

United States, Canad...

Eli Lilly and Company

NCT07109700 Phase 2

A Study of HDM1005 in Participants With T2DM Not Controlled With Diet/Exercise or Metformin

Hangzhou Zhongmei Huadong Phar...

My ESSENCE - A Research Study on Mindfulness for African-Americans With Type 2 Diabetes

University of Illinois at Chic...

Relationship Between Red Cell Distribution Width (RDW) and HbA1C in Patients With Type 2 Diabetes Mellitus After Glycemic Control

New Valley University

Mortality and Cardiovascular Diseases in Adult-onset Type 1 Diabetes

Karolinska Institutet

Feasibility of Aerobic Exercise With Blood Flow Restriction Training in People Living With Type 2 Diabetes

University of New Brunswick

Related Conditions

type 1 diabetes (2) obesity (2) sleep (2) healthy (1) whole body vibration (1) muscle oxygenation (1) aerobic exercise (1) pregnancy in diabetic (1) parents (1) fetal complications (1) maternal diabetes (1) birth injuries (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology