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type 2 diabetes

Total Trials

38

Recruiting Now

38

Trial Phases

Phase 3, Phase 4, Phase 1

Type 2 diabetes trials focus on achieving durable glycemic control while reducing cardiovascular mortality, kidney disease progression, and body weight β€” goals now achievable with newer drug classes that were unavailable a decade ago. The success of GLP-1 receptor agonists and SGLT2 inhibitors in cardiovascular outcome trials has reshaped trial design toward hard endpoint studies.

Active research areas include novel GLP-1 analogs with improved dosing profiles, combination GLP-1/GIP/glucagon triagonists, once-weekly oral formulations, bariatric surgery comparisons, and precision medicine approaches to match patients to optimal drug classes based on genetics, microbiome, or biomarkers.

Trials typically require a confirmed type 2 diagnosis with HbA1c in a specified range; cardiovascular outcome trials often require existing heart disease or high cardiovascular risk.

Frequently Asked Questions — type 2 diabetes Clinical Trials

How many clinical trials are currently recruiting for type 2 diabetes?

ClinicalMetric currently tracks 38 actively recruiting clinical trials for type 2 diabetes, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 38. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for type 2 diabetes?

type 2 diabetes research spans Phase 1 (5 trials), Phase 2 (3 trials), Phase 3 (3 trials), Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a type 2 diabetes clinical trial?

Eligibility criteria for type 2 diabetes trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

5

Phase 2

3

Phase 3

3

Phase 4

2

Top Sponsors

University of California, San Diego 2 trials

University of Montana 1 trial

Novo Nordisk A/S 1 trial

University of Illinois at Urbana-Champaign 1 trial

Marzieh Salehi 1 trial

Recruiting Clinical Trials

The Food for Health Study

University of Montana

NCT07564414 Phase 3

A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

United States, Argen...

Novo Nordisk A/S

Exercise and Protein Efficiency in T2D

University of Illinois at Urba...

NCT06706284 Phase 4

Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes

NCT05702463 Phase 1

Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes II

Montreal Heart Institute

Developing and Testing a Self-Compassion Tool Kit to Improve the Care of Individuals With Type 2 Diabetes

University of California, San ...

Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

University of Colorado, Denver

Pilot-Testing Strategies to Improve Outcomes for Youth With Type 2 Diabetes by Addressing Health-Related Social Needs

University of Pittsburgh

Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality

Clinica Universidad de Navarra...

Hydroxychloroquine in Type 2 Diabetes During Pregnancy

National University of Malaysi...

NCT07193459 Phase 3

Study to Evaluate HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus

Hangzhou Zhongmei Huadong Phar...

NCT06143566 Phase 1, Phase 2

Polypill for Prevention of Cardiomyopathy

University of Texas Southweste...

Pilot of Continuous Glucose Monitor-Augmented Food Is Medicine

University of North Carolina, ...

Hybrid Closed-Loop for Perioperative Glycemic Control in T2DM With Parenteral Nutrition

Second Xiangya Hospital of Cen...

NCT06589765 Phase 3

A Study of HRS-7535 Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequately Controlled With Metformin

Shandong Suncadia Medicine Co....

Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus

Academisch Medisch Centrum - U...

Whole Body Vibration Therapy in Individuals With Type 2 Diabetes

Turkey (Türkiye)

Ankara Medipol University

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

University of Michigan

NCT07374328 Phase 1, Phase 2

Triple Hypoglycemic Regimens In Patients With Newly Diagnosed Type 2 Diabetes Mellitus

Second Affiliated Hospital of ...

Dissecting Host-microbiome Modifiers of Type 2 Diabetes Risk

Laval University

The Next Generation Longitudinal Birth Cohort Diabetes Study

University of Manitoba

LINK-IT: Leveraging vIdeos and commuNity Health worKers to Improve Diabetes OuTcomes

NYU Langone Health

Liver Transplant CGM

Icahn School of Medicine at Mo...

Relationship Between Red Cell Distribution Width (RDW) and HbA1C in Patients With Type 2 Diabetes Mellitus After Glycemic Control

New Valley University

More Fresh Fruit and Vegetable Prescription Program for Families With Type 2 Diabetes Mellitus

University of California, San ...

Human Genes and Microbiota in Early Life

Guangzhou Women and Children's...

Ketogenic Diet and Diabetes Demonstration Project

University of New Mexico

Feasibility of Aerobic Exercise With Blood Flow Restriction Training in People Living With Type 2 Diabetes

University of New Brunswick

NCT07053293 EARLY_Phase 1

SGLT2i, Hepatic Glucose Production, and SNS

The University of Texas Health...

Remission of Diabetes With Lifestyle Intervention for Malaysian Patients

Winnie Chee Siew Swee

The GRoceries Aimed at Increasing Nutrition Study

University of Pennsylvania

Effect of Partial Dietary Replacement From Animal to Plant-Based Protein for Type 2 Diabetes Management

Hospital de Clinicas de Porto ...

The European NAFLD Registry

Belgium, Finland, Fr...

Newcastle University

NCT06657209 Phase 4

Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide

Stanford University

NCT07296484 Phase 2

Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

Sparrow Pharmaceuticals

NCT07568678 Phase 1

A Phase 1, Multiple Ascending Dose Study to Evaluate HMS1005 in Participants With Type 2 Diabetes

Hua Medicine Limited

Epigenetics and NCD Prevention in Kazakhstan: Personalized Approaches and Biological Age Prediction

Asfendiyarov Kazakh National M...

Effect of Bempedoic Acid on Liver Fat in Individuals With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes

Medanta, The Medicity, India

Related Conditions

obesity (6) diabetes mellitus type 2 (3) diabetes (2) cardiovascular diseases (2) prediabetes (2) pre diabetes (2) food insecurity (1) rural health (1) control condition (1) spinal cord injuries (1) platelet aggregation (1) aspirin (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology