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type 2 diabetes

Total Trials

37

Recruiting Now

37

Trial Phases

EARLY_Phase 1, Phase 1, Phase 4

Type 2 diabetes trials focus on achieving durable glycemic control while reducing cardiovascular mortality, kidney disease progression, and body weight β€” goals now achievable with newer drug classes that were unavailable a decade ago. The success of GLP-1 receptor agonists and SGLT2 inhibitors in cardiovascular outcome trials has reshaped trial design toward hard endpoint studies.

Active research areas include novel GLP-1 analogs with improved dosing profiles, combination GLP-1/GIP/glucagon triagonists, once-weekly oral formulations, bariatric surgery comparisons, and precision medicine approaches to match patients to optimal drug classes based on genetics, microbiome, or biomarkers.

Trials typically require a confirmed type 2 diagnosis with HbA1c in a specified range; cardiovascular outcome trials often require existing heart disease or high cardiovascular risk.

Frequently Asked Questions — type 2 diabetes Clinical Trials

How many clinical trials are currently recruiting for type 2 diabetes?

ClinicalMetric currently tracks 37 actively recruiting clinical trials for type 2 diabetes, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 37. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for type 2 diabetes?

type 2 diabetes research spans Phase 1 (5 trials), Phase 2 (2 trials), Phase 3 (4 trials), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a type 2 diabetes clinical trial?

Eligibility criteria for type 2 diabetes trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

5

Phase 2

2

Phase 3

4

Phase 4

3

Top Sponsors

Ohio State University 2 trials

University of Colorado, Denver 1 trial

Kuopio University Hospital 1 trial

Hospices Civils de Lyon 1 trial

New Valley University 1 trial

Recruiting Clinical Trials

NCT07409714 EARLY_Phase 1

SMART 2D: Study of Montelukast's Effects on Renal and Cardiovascular Health in Adolescents and Young Adults With Type 2 Diabetes

University of Colorado, Denver

Outcomes-Based Health Program for Type 2 Diabetes

Kuopio University Hospital

PBMC as Biomarkers of Diabetic Cardiomyopathy

Hospices Civils de Lyon

Relationship Between Red Cell Distribution Width (RDW) and HbA1C in Patients With Type 2 Diabetes Mellitus After Glycemic Control

New Valley University

Diabetes Registry Graz for Biomarker Research

Medical University of Graz

Joint Patient and Caregiver Intervention for Older African Americans With Type 2 Diabetes

Medical College of Wisconsin

Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

State University of New York a...

Sleeve Gastrectomy and Roux-en-Y Gastric Bypass in the Treatment of Type 2 Diabetes Mellitus.

Göteborg University

NCT07778524 Phase 1

Alpelisib Challenge Test (ACT)

Columbia University

NCT06932874 Phase 4

Metformin Hydrochloride Sustained-release Tablets (Ⅲ) in Patients With Type 2 Diabetes Mellitus Complicated With Coronary Heart Disease

China National Center for Card...

Cognitive Screening and Multidomain Intervention Targeting Cognitive Decline in Type 2 Diabetes (The Brain Care Study)

Steno Diabetes Center Copenhag...

NCT07539415 Phase 1

A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers

Daewoong Pharmaceutical Co. LT...

NCT07307235 Phase 4

Efficacy and Safety of iGlarLixi Versus Standard of Care in a Real-world Adult China Population With Uncontrolled Type 2 Diabetes on Oral Agents

Shanghai Zhongshan Hospital

NCT07293715 Phase 4

Permissive Versus Strict Intrapartum Glucose Management in Type 1 and Type 2 Diabetes (PRISM)

Ohio State University

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

Ohio State University

Effect of Bempedoic Acid on Liver Fat in Individuals With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes

Medanta, The Medicity, India

ACT Intervention for Type 2 Diabetes Management for Rural and Underserved Community

Sam Houston State University

NCT07146347 Phase 1

Comparison Study of Insulin GZR4 With Insulin Degludec

Gan and Lee Pharmaceuticals, U...

NCT07060456 Phase 3

Efficacy and Safety of HRS9531 in Participants With Type 2 Diabetes Treated With Basal Insulin

Fujian Shengdi Pharmaceutical ...

The Effect of Exercise on the Brain in Type 2 Diabetes

Hasselt University

Assessing the Efficacy of Targeted Home Visits in the Management of Chronic Conditions

University of Texas Southweste...

NCT07193459 Phase 3

Study to Evaluate HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus

Hangzhou Zhongmei Huadong Phar...

NCT07659574 Phase 3

Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Diet and Exercise Alone（UNIGUIDE-1）

The United Bio-Technology (Hen...

GLycaemic Outcomes With Whey Protein in ageING

University of Birmingham

KPSC MNT Pilot RCT

Kaiser Permanente

Prospective Evaluation of a Dose Guidance System for People With Diabetes Initiating Basal Insulin or Using Insulin Injections

Israel, Slovenia

Rabin Medical Center

NCT07675499 Phase 2, Phase 3

Exercise and Intranasal Insulin in Type 2 Diabetes

Rutgers, The State University ...

Primary Prevention With the Lifestyle Tool

Evaluation of the Impact of Psychological Profile on Diabetic Foot Wound Healing.

Centre Hospitalier Universitai...

NCT07546929 Phase 2

HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes

Housey Healthcare ULC

Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study

Nottingham University Hospital...

Nottingham Community Liver Biomarkers Cohort

University of Nottingham

Periodic Continuous Glucose Monitoring in Patients With Type 2 Diabetes

Sophiahemmet University

iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic Diseases

Brazil, Chile, Costa...

NCT07868354 Phase 1

A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication

Novo Nordisk A/S

Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

University of Utah

Latinos Understanding the Need for Adherence in Diabetes Using E-Health

San Diego State University

Related Conditions

obesity overweight (3) obesity (3) type 1 diabetes (2) hypertension (2) metabolic syndrome (1) heart failure with preserved ejection fraction (1) heart failure with mildly reduced ejection fraction (1) type1diabetes (1) adiposity (1) type 2 diabetes adult onset (1) obesity type 2 diabetes mellitus (1) dehydration (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology