Browse by Phase
Phase 4 Clinical Trials
Phase 4 trials (post-market surveillance) occur after a drug has been approved. They monitor long-term effectiveness and safety in general patient populations.
Total Trials
348
Recruiting Now
348
Top Conditions in Phase 4
Frequently Asked Questions — Phase 4 Trials
What is the purpose of a Phase 4 post-market clinical trial?
Phase 4 trials occur after a drug has received regulatory approval. They monitor long-term effectiveness and safety in real-world patient populations, detect rare adverse events too infrequent to appear in earlier trials, study effectiveness in subgroups (elderly, pediatric, renally impaired), and may explore new indications for the approved drug. Some Phase 4 studies are mandated by the FDA as a condition of approval.
Who sponsors Phase 4 trials?
Phase 4 trials are primarily sponsored by pharmaceutical and biotech companies that hold the drug's marketing authorization. Some are mandated by the FDA or EMA—particularly when approval was based on surrogate endpoints and confirmatory long-term data is required. Independent academic institutions and registry-based programs also conduct Phase 4 studies.
Are Phase 4 trials safer than Phase 1–3 trials?
Phase 4 trials involve drugs that have already demonstrated an acceptable safety profile in earlier phases and received regulatory approval. As a result, the risk profile for participants is generally better characterized than in early-phase trials. However, these studies are still clinical research designed partly to detect long-term or rare adverse events not observed in pre-approval trials.
Active Phase 4 Studies
NCT07435337 Phase 4
Recruiting
Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy
Condition
Laryngoscopy
Enrollment
98 pts
Location
Pakistan
Sponsor
Rawalpindi Institute of Cardio
NCT07612267 Phase 4
Recruiting
A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants R...
Condition
Lactation
Enrollment
14 pts
Location
United States, Canada, Denmark
Sponsor
Eli Lilly and Company
NCT07387536 Phase 4
Recruiting
The Effectiveness of Topical Silicone Application Combined With Photoprotection ...
Condition
Scar Formation
Enrollment
30 pts
Location
Mexico
Sponsor
Instituto de Oftalmología Fund
NCT05534971 Phase 4
Recruiting
Central Line Study
Condition
Shock
Enrollment
160 pts
Location
United States
Sponsor
Montefiore Medical Center
NCT06864130 Phase 4
Recruiting
A Clinical Study on the Effect of Discontinuing Alendronate in Postmenopausal Wo...
Condition
Osteoporosis in Post-menopausal Women
Enrollment
1,400 pts
Location
Denmark
Sponsor
Odense University Hospital
NCT06291155 Phase 4
Recruiting
Mechanism of SGLT2 Inhibition in the Kidney
Condition
Type 2 Diabetes
Enrollment
20 pts
Location
United States
Sponsor
University of Michigan
NCT06342115 Phase 4
Recruiting
Ceftolozane/Tazobactam Versus Meropenem for Febrile Neutropenia on Patients Colo...
Condition
Febrile Neutropenia
Enrollment
55 pts
Location
Brazil
Sponsor
Beneficência Portuguesa de São
NCT06473597 Phase 4
Recruiting
A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine ...
Condition
Migraine
Enrollment
80 pts
Location
United States
Sponsor
Antonios Likourezos
NCT03705585 Phase 4
Recruiting
CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera
Condition
Typhoid and/or Cholera Vaccination
Enrollment
240 pts
Location
United States
Sponsor
University of Maryland, Baltim
NCT04650243 Phase 4
Recruiting
Clinical Research of Tapering UDCA in PBC Patients With a Complete Response
Condition
Primary Biliary Cholangitis
Enrollment
90 pts
Location
China
Sponsor
Peking Union Medical College H
NCT04916197 Phase 4
Recruiting
Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful...
Condition
Acute Ischemic Stroke
Enrollment
368 pts
Location
China
Sponsor
Beijing Chao Yang Hospital
NCT06866691 Phase 4
Recruiting
Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide
Condition
Traumatic Brain Injury
Enrollment
600 pts
Location
United States
Sponsor
Wake Forest University Health
NCT05919797 Phase 4
Recruiting
Weight Loss Study: Genetics and Response to Naltrexone/Bupropion
Condition
Obesity
Enrollment
120 pts
Location
United States
Sponsor
Columbia University
NCT06403943 Phase 4
Recruiting
Efficacy Safety BaiDiZiYin ShenQiYiFei Adjunctive Treatments Pulmonary Tuberculo...
Condition
Adjuvant
Enrollment
292 pts
Location
China
Sponsor
Beijing Chest Hospital
NCT06148025 Phase 4
Recruiting
Antibiotics and Vaccine Immune Responses Study
Condition
Vaccine Response Impaired
Enrollment
348 pts
Location
Australia
Sponsor
South Australian Health and Me
NCT07376148 Phase 4
Recruiting
Fractional CO2 Laser-assisted Delivery of Hyaluronic Acid, Ascorbic Acid and Sod...
Condition
Skin Quality Improvement
Enrollment
30 pts
Location
Mexico
Sponsor
Instituto de Oftalmología Fund
NCT04460235 Phase 4
Recruiting
Clinical Trial Assessing the Immunogenicity of an Anti-pneumococcal Vaccination ...
Condition
Vaccine
Enrollment
160 pts
Location
France
Sponsor
Poitiers University Hospital
NCT07028125 Phase 4
Recruiting
Digital Monitoring of Self-reported Symptoms by Patients Treated With Cabozantin...
Condition
Renal Cell Carcinoma (Kidney Cancer)
Enrollment
83 pts
Location
France
Sponsor
Centre Francois Baclesse
NCT04873050 Phase 4
Recruiting
Treatment to Regress to Normoglycemia in Women with a Recent History of GDM
Condition
Pre Diabetes
Enrollment
102 pts
Location
United States
Sponsor
Woman's
NCT05972018 Phase 4
Recruiting
Liposomal Bupivacaine/Bupivacaine in Rectus Sheath Blocks Versus Ropivacaine in ...
Condition
Aortic Aneurysm, Abdominal
Enrollment
14 pts
Location
United States
Sponsor
Hartford Hospital
NCT06565910 Phase 4
Recruiting
Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for Pericapsular Nerve Grou...
Condition
Femoral Neck Fractures
Enrollment
60 pts
Location
China
Sponsor
Huazhong University of Science
NCT04991389 Phase 4
Recruiting
Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid...
Condition
Obstructive Sleep Apnea
Enrollment
120 pts
Location
United States
Sponsor
Children's Hospital Medical Ce
NCT07145697 Phase 4
Recruiting
The Electroencephalographic Mechanisms of Anesthesia and Human Consciousness
Condition
Consciousness, Level Altered
Enrollment
30 pts
Location
China
Sponsor
Guangzhou General Hospital of
NCT06745388 Phase 4
Recruiting
Magnesium and Cramping
Condition
Uterine Cramps
Enrollment
150 pts
Location
United States
Sponsor
Corewell Health East
NCT05508256 Phase 4
Recruiting
CAtheter-Based Ablation of Atrial Fibrillation Compared to Conventional Treatmen...
Condition
Atrial Fibrillation
Enrollment
1,548 pts
Location
Germany
Sponsor
Charite University, Berlin, Ge
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology