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pain postoperative

Total Trials
11
Recruiting Now
11
Trial Phases
Phase 4

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — pain postoperative Clinical Trials

How many clinical trials are currently recruiting for pain postoperative?
ClinicalMetric currently tracks 11 actively recruiting clinical trials for pain postoperative, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 11. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for pain postoperative?
pain postoperative research spans Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a pain postoperative clinical trial?
Eligibility criteria for pain postoperative trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 4
2
Top Sponsors
University of Southern California 1 trial
Columbia University 1 trial
Boston Children's Hospital 1 trial
Uppsala University 1 trial
ASST Gaetano Pini-CTO 1 trial

Recruiting Clinical Trials

NCT05746143 Phase 4
Recruiting
The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion
Enrollment
140 pts
Location
United States
Sponsor
University of Southern Califor...
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NCT06456268
Recruiting
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)
Enrollment
130 pts
Location
United States
Sponsor
Columbia University
View Trial →
NCT04439552
Recruiting
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Enrollment
60 pts
Location
United States
Sponsor
Boston Children's Hospital
View Trial →
NCT06145516
Recruiting
Promoting Sleep to Alleviate Pain - Arthroplasty
Enrollment
100 pts
Location
Sweden
Sponsor
Uppsala University
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NCT07239817
Recruiting
PENG Block + LIA For Endoprosthesis Surgery
Enrollment
100 pts
Location
Italy
Sponsor
ASST Gaetano Pini-CTO
View Trial →
NCT07650877
Recruiting
Comparison of the Rhomboid Intercostal Block and Serratus Posterior Superior Intercostal Plane Block
Enrollment
90 pts
Location
Turkey (Türkiye)
Sponsor
Ankara City Hospital Bilkent
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NCT06817239
Recruiting
Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)
Enrollment
1,670 pts
Location
China
Sponsor
Nanfang Hospital, Southern Med...
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NCT06761989
Recruiting
Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy
Enrollment
104 pts
Location
South Korea
Sponsor
Seoul National University Hosp...
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NCT07689461
Recruiting
VR Effects After Hip Replacement Surgery Pain
Enrollment
80 pts
Location
Turkey (Türkiye)
Sponsor
Adiyaman University
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NCT04860141 Phase 4
Recruiting
Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.
Enrollment
98 pts
Location
United States
Sponsor
Loma Linda University
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NCT07739277
Recruiting
Transverse vs. Longitudinal Serratus Anterior Plane Block in Breast Surgery
Enrollment
70 pts
Location
Turkey (Türkiye)
Sponsor
Ankara Etlik City Hospital
View Trial →

Related Conditions

spine fusion (1) lumbar spine degeneration (1) lumbar spine spondylosis (1) acl (1) opioid use (1) cryotherapy effect (1) vibration exposure (1) pain chronic (1) pain acute (1) surgical injury (1) surgical wound (1) cornea injury (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: September 2026  ·  Data Methodology