Medical Condition

pain postoperative

Total Trials

13

Recruiting Now

13

Trial Phases

Phase 2, Phase 3, Phase 4

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — pain postoperative Clinical Trials

How many clinical trials are currently recruiting for pain postoperative?

ClinicalMetric currently tracks 13 actively recruiting clinical trials for pain postoperative, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 13. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for pain postoperative?

pain postoperative research spans Phase 2 (2 trials), Phase 3 (2 trials), Phase 4 (6 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a pain postoperative clinical trial?

Eligibility criteria for pain postoperative trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

Phase 3

Phase 4

Top Sponsors

Stanford University 2 trials

Tanta University 1 trial

Universidade Federal do Rio de Janeiro 1 trial

Universitätsklinikum Hamburg-Eppendorf 1 trial

ASST Gaetano Pini-CTO 1 trial

Recruiting Clinical Trials

NCT04109638

Recruiting

Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery

Ultrasound Guided Sacral Erector Spinae Plane Block Versus Ultrasound Guided Caudal Block in Pediatric Undergoing Hypospadias Surgery

NCT07062497 Phase 2, Phase 3

Recruiting

Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty

Universidade Federal do Rio de...

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NCT06905340

Recruiting

Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia

Universitätsklinikum Hamburg-E...

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NCT07239817

Recruiting

PENG Block + LIA For Endoprosthesis Surgery

ASST Gaetano Pini-CTO

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NCT05351229 Phase 4

Recruiting

Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

Northwestern University

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NCT03737292 Phase 4

Recruiting

Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy

Milton S. Hershey Medical Cent...

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NCT04577690 Phase 4

Recruiting

PECS Study for CIED Implantation Surgery

The Hospital for Sick Children

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NCT06189781 Phase 4

Recruiting

Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy

University of California, Los ...

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NCT06817239

Recruiting

Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)

Nanfang Hospital, Southern Med...

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NCT03230565 Phase 4

Recruiting

Continuous Infusions vs Scheduled Bolus Infusions

NCT04724252 Phase 2, Phase 3

Recruiting

Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children

University of California, Davi...

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NCT06949826 Phase 4

Recruiting

Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

Related Conditions

knee injuries (1) shoulder injuries (1) hypospadias (1) caudal block (1) erector spinae plane block (1) hernia umbilical (1) clonidine (1) ambulatory surgical procedures (1) regional anesthesia block (1) nociceptive pain (1) analgesia postoperative (1) anesthesia recovery period (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology