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Medical Condition

sepsis

Total Trials

34

Recruiting Now

34

Trial Phases

Phase 1, Phase 2, Phase 4

ClinicalMetric tracks all active clinical trials for sepsis sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — sepsis Clinical Trials

How many clinical trials are currently recruiting for sepsis?

ClinicalMetric currently tracks 34 actively recruiting clinical trials for sepsis, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 34. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for sepsis?

sepsis research spans Phase 1 (2 trials), Phase 2 (1 trial), Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a sepsis clinical trial?

Eligibility criteria for sepsis trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

2

Phase 2

1

Phase 4

2

Top Sponsors

Brugmann University Hospital 1 trial

Universität Münster 1 trial

Dr Cipto Mangunkusumo General Hospital 1 trial

University of California, San Francisco 1 trial

University of Maryland, Baltimore 1 trial

Recruiting Clinical Trials

Glycosylated Ferritin in Macrophagic Activation Syndromes

Brugmann University Hospital

Remote Ischemic Preconditioning in Septic Patients

Universität Münster

Molecular-based Optimization of Pathogen Identification in Sepsis Patients in the Indonesian National Referral Hospital

Dr Cipto Mangunkusumo General ...

Role of Transposable Elements in Septic Immune Aging

University of California, San ...

UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial

University of Maryland, Baltim...

Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates

United States, Kenya

University of California, Berk...

Defining Volume Status in Sepsis With Extracellular Water Measurement

Uppsala University

OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study

Pauls Stradins Clinical Univer...

Evaluation of Blood Protein O-GlcNAcylation Levels in Children

Nantes University Hospital

Long-term Assessment of Patients Treated in the ICU for Sepsis

Hospital Israelita Albert Eins...

Sepsis-associated Thrombocytopenia and Platelet Transfusion （STAPT）

Nanfang Hospital, Southern Med...

Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis

Ain Shams University

NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot

St. Olavs Hospital

Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock

First Affiliated Hospital of Z...

NCT06854640 Phase 1

A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy

United States, Belgi...

Prediction of Mortality and Morbidity After Hip Fracture Using Monocyte Distribution Width (MDW)

National and Kapodistrian Univ...

Characterisation of Endothelial Cells in Different Inflammatory Pathologies

Royal Surrey County Hospital N...

Sepsis and Hospital Mortality

University of Calabria

Characterization and Longitudinal Monitoring of Muscular Phenotype in Patients Admitted to Intensive Care for Sepsis

Centre Hospitalier de Saint-Br...

Early Severe Illness TrAnslational BioLogy InformaticS in Humans

London Health Sciences Centre ...

KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic Use - Comparing Procalcitonin Kinetics-guided and Absolute Procalcitonin Value-guided Antibiotic Initiation in Reducing Unnecessary Antibiotic Use in Critically Ill Patients

Semmelweis University

Metabolic and Functional Study of γδ T Cells in Critically Ill Patients

Union Hospital, Tongji Medical...

Sepsis Multiomic Analysis & Risk sTratification in China

Yuebei People's Hospital

Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?

Michigan State University

Lactate Kinetics in Septic Shock

Karolinska University Hospital

NCT03334006 Phase 2

Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis

Austria, Germany

RWTH Aachen University

Effect of Targeting Upper Normal Serum Magnesium Levels on Norepinephrine Requirements in Septic Shock Patients

Alexandria University

Erector Spinae Plane Block Improves Organ Dysfunction in Septic Patients With Acute Gastrointestinal Injury

NCT05770622 Phase 4

Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)

Murdoch Childrens Research Ins...

NCT06670963 Phase 4

Use of Epoetin Alfa and Iron Derisomaltose in Treatment of Anemia in Patients With Sepsis or Septic Shock: a Randomized Controlled Trial

Severe Sepsis and Septic Shock Registry

Seoul National University Hosp...

Mechanisms of Acute Kidney Injury in Severe Infections

Uppsala University Hospital

NCT05453695 Phase 1

Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)

McMaster University

Temperature Optimization in Afebrile Septic PatienTs

Related Conditions

septic shock (7) critical illness (3) still s disease adult onset (1) macrophagic activation syndrome (1) critically ill (1) acute kidney injury (1) antimicrobial resistance amr (1) sepsis and septic shock (1) sepsis with multiple organ dysfunction mod (1) sepsis with acute organ dysfunction (1) sepsis severe (1) sepsis at intensive care unit (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology