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Medical Condition

sepsis

Total Trials

27

Recruiting Now

27

Trial Phases

Phase 2, Phase 4, Phase 3

ClinicalMetric tracks all active clinical trials for sepsis sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — sepsis Clinical Trials

How many clinical trials are currently recruiting for sepsis?

ClinicalMetric currently tracks 27 actively recruiting clinical trials for sepsis, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 27. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for sepsis?

sepsis research spans Phase 2 (4 trials), Phase 3 (1 trial), Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a sepsis clinical trial?

Eligibility criteria for sepsis trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

4

Phase 3

1

Phase 4

2

Top Sponsors

Ain Shams University 2 trials

Ottawa Hospital Research Institute 1 trial

AstraZeneca 1 trial

Radboud University Medical Center 1 trial

University of British Columbia 1 trial

Recruiting Clinical Trials

NCT05969275 Phase 2

Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock

Ottawa Hospital Research Insti...

NCT07215702 Phase 2

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

United States, Argen...

NCT06624436 Phase 4

Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia

Radboud University Medical Cen...

Precision Exercise to Improve Outcomes in Sepsis

University of British Columbia

Cytokine REmoval in CRitically Ill PAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE)

Insel Gruppe AG, University Ho...

Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis

Third Affiliated Hospital, Sun...

NCT06381661 Phase 2

Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial

Assistance Publique - Hôpitaux...

Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine

University Medical Center Gron...

Evaluation of Pediatric eCART Implementation

University of Wisconsin, Madis...

Sulbactam-Durlobactam in CRAB Infection: A Real-World Cohort Study

Sichuan Provincial People's Ho...

NCT04910464 Phase 3

Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis

Assiut University

Rapid Molecular Diagnosis of Sepsis in the Intensive Care Unit

Maastricht University Medical ...

Call for Life Sepsis

Makerere University

Personalized Fluid Resuscitation in the Emergency Department: A Pilot Trial

Intermountain Health Care, Inc...

Fosfomycin I.v. for Treatment of Severely Infected Patients

Austria, Germany, Gr...

Infectopharm Arzneimittel GmbH

NCT07413094 Phase 2

Efficacy and Safety of YD0743 Treatment for Sepsis-Associated ARDS

Shanghai Yidian Pharmaceutical...

MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients

Health Discovery Labs

A Comparative Study Between Neutrophil/Lymphocyte Ratio and Lactate/Albumin Ratio as Predictive Inflammatory Markers for Sepsis

Ain Shams University

Immunothrombosis With Septic Shock Undergoing Renal Replacement Therapy With the OXIRIS Membrane

University Hospital, Bordeaux

Validation of Hematological Indices

Petrovsky National Research Ce...

NCT06570187 Phase 4

The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients

Cairo University

Transcutaneous Auricular Vagus Nerve Stimulation as Adjuvant Treatment for Sepsis Patients

Third Military Medical Univers...

Mechanisms of Acute Kidney Injury in Severe Infections

Uppsala University Hospital

Efficacy of SGLT2 Inhibitors in Adults With Sepsis

Hospital Authority, Hong Kong

Pathological Myeloid Activation After Sepsis and Trauma

University of Florida

Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit

University Medical Centre Mari...

Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness

Ain Shams University

Related Conditions

septic shock (4) acute kidney injury (3) pneumonia (3) shock (2) inflammation (2) urinary tract infections (2) bloodstream infection (2) pathologic processes (1) systemic inflammatory response syndrome (1) infections (1) neuroinflammatory response (1) immunosuppresion (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology