Medical Condition

acute ischemic stroke

Total Trials

23

Recruiting Now

23

Trial Phases

Phase 2, Phase 3, Phase 1, Phase 2

Stroke trials address both acute treatment (revascularization within hours of onset) and long-term secondary prevention, with rehabilitation science emerging as a distinct research priority. Advances in thrombectomy techniques have dramatically improved outcomes for large vessel occlusion strokes, driving trials to push the treatment window from 6 to 24 hours in selected patients.

Current research includes tenecteplase vs alteplase for thrombolysis, thrombectomy for medium vessel occlusions, neuroprotective agents, factor XIa inhibitors for secondary prevention with lower bleeding risk, and telerehabilitation using robotics and brain-computer interfaces. Trials in wake-up stroke and unknown time-of-onset have expanded using MRI mismatch criteria.

Frequently Asked Questions — acute ischemic stroke Clinical Trials

How many clinical trials are currently recruiting for acute ischemic stroke?

ClinicalMetric currently tracks 23 actively recruiting clinical trials for acute ischemic stroke, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 23. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for acute ischemic stroke?

acute ischemic stroke research spans Phase 1 (1 trial), Phase 2 (3 trials), Phase 3 (6 trials), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a acute ischemic stroke clinical trial?

Eligibility criteria for acute ischemic stroke trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 3

Phase 4

Top Sponsors

Xuanwu Hospital, Beijing 2 trials

Amrou Sarraj 1 trial

Washington University School of Medicine 1 trial

Beijing Tiantan Hospital 1 trial

Fujian Medical University Union Hospital 1 trial

acute ischemic stroke

Frequently Asked Questions — acute ischemic stroke Clinical Trials

Recruiting Clinical Trials

Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well

Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke

Prognostic Prediction Model of Patients With AcUte Stroke undeRgoing EndOvascular TheRApy (AURORA)

A Prospective Multicenter Registry Study on BASIS Technique for Endovascular Therapy of Acute Large Vessel Occlusion Strokes Due to Intracranial Atherosclerotic Disease

Safety and Efficacy Evaluation of the Ceretrieve Device in the Treatment of AIS Patients

HRS-7450 Injection Phase II Clinical Trial for Acute Ischemic Stroke.

Intra-arterial Methylprednisolone After Successful Endovascular Thrombectomy Anterior Circulation Large Vessel Occlusion

Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

The Effect of GD-iExo-003 in Acute Ischemic Stroke

Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)

Triage of Patients Presenting Beyond 24 Hours With Acute Ischemic Stroke Due to Large Vessel Occlusions (TRACK-LVO Late)

Precision Antiplatelet Therapy Guided by Platelet Aggregation Function in Patients With Acute Ischemic STROKE

Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours

Role of EEG in Differentiation Between Ischemic and Hemorrhagic Stroke

Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke

Acute Ischemic Stroke EndoVascular Therapy: a Multicenter REGISTRY Study

German Stroke Registry - Endovascular Treatment

Evaluation of Acute Endovascular Treatment in Symptomatic Isolated Cervical Internal Carotid Artery Occlusion (ETICA)

Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke

Predictive Role of sTREM in Endovascular Thrombectomy Outcomes

OPtimizing REperfusion by Intra-Arterial ThRomboLysis as Adjunct to Endovascular Treatment for Medium Vessel Occlusion

Intravenous Thrombolysis Combined With Tirofiban in Acute Ischemic Stroke

Acute Subcutaneous SemaglutidE in Acute Ischemic sTroke